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- W4309179933 abstract "Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes, is a major cause of vision loss among middle-aged people worldwide, and the number of DR patients will increase with the increasing incidence of diabetes. At present, it is limited in difficult detection in the early stages, limited treatment and unsatisfactory treatment effects in the advanced stages.The pathogenesis of DR is complicated and involves epigenetic modifications, oxidative stress, inflammation and neovascularization. These factors influence each other and jointly promote the development of DR. DNA methylation is the most studied epigenetic modification, which has been a key role in the regulation of gene expression and the occurrence and development of DR. Thus, this review investigates the relationship between DNA methylation and other complex pathological processes in the development of DR. From the perspective of DNA methylation, this review provides basic insights into potential biomarkers for diagnosis, preventable risk factors, and novel targets for treatment.DNA methylation plays an indispensable role in DR and may serve as a prospective biomarker of this blinding disease in its relatively early stages. In combination with inhibitors of DNA methyltransferases can be a potential approach to delay or even prevent patients from getting advanced stages of DR." @default.
- W4309179933 created "2022-11-24" @default.
- W4309179933 creator A5031325476 @default.
- W4309179933 creator A5051240702 @default.
- W4309179933 creator A5058464661 @default.
- W4309179933 creator A5063858428 @default.
- W4309179933 creator A5068442139 @default.
- W4309179933 creator A5068461752 @default.
- W4309179933 creator A5072783081 @default.
- W4309179933 creator A5076303484 @default.
- W4309179933 date "2022-11-17" @default.
- W4309179933 modified "2023-10-14" @default.
- W4309179933 title "DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets" @default.
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