Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309181444> ?p ?o ?g. }
- W4309181444 abstract "Abstract Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck." @default.
- W4309181444 created "2022-11-24" @default.
- W4309181444 creator A5001459507 @default.
- W4309181444 creator A5002187739 @default.
- W4309181444 creator A5003191912 @default.
- W4309181444 creator A5003460678 @default.
- W4309181444 creator A5005885147 @default.
- W4309181444 creator A5006198216 @default.
- W4309181444 creator A5006977278 @default.
- W4309181444 creator A5013399255 @default.
- W4309181444 creator A5020235495 @default.
- W4309181444 creator A5020635446 @default.
- W4309181444 creator A5021281252 @default.
- W4309181444 creator A5028575450 @default.
- W4309181444 creator A5037601897 @default.
- W4309181444 creator A5039412398 @default.
- W4309181444 creator A5045898861 @default.
- W4309181444 creator A5047367423 @default.
- W4309181444 creator A5049493093 @default.
- W4309181444 creator A5063393036 @default.
- W4309181444 creator A5069155134 @default.
- W4309181444 creator A5071129241 @default.
- W4309181444 creator A5075521359 @default.
- W4309181444 creator A5078475181 @default.
- W4309181444 creator A5079611387 @default.
- W4309181444 creator A5087601456 @default.
- W4309181444 date "2022-11-11" @default.
- W4309181444 modified "2023-10-14" @default.
- W4309181444 title "Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations" @default.
- W4309181444 cites W1920487205 @default.
- W4309181444 cites W1967134059 @default.
- W4309181444 cites W1979677919 @default.
- W4309181444 cites W2000971200 @default.
- W4309181444 cites W2001036195 @default.
- W4309181444 cites W2022948175 @default.
- W4309181444 cites W2027653803 @default.
- W4309181444 cites W2045716211 @default.
- W4309181444 cites W2068768225 @default.
- W4309181444 cites W2080419167 @default.
- W4309181444 cites W2080873675 @default.
- W4309181444 cites W2081938446 @default.
- W4309181444 cites W2082976148 @default.
- W4309181444 cites W2092454947 @default.
- W4309181444 cites W2093044565 @default.
- W4309181444 cites W2096014252 @default.
- W4309181444 cites W2096093282 @default.
- W4309181444 cites W2099085143 @default.
- W4309181444 cites W2105621710 @default.
- W4309181444 cites W2108018752 @default.
- W4309181444 cites W2110335151 @default.
- W4309181444 cites W2110372439 @default.
- W4309181444 cites W2115011276 @default.
- W4309181444 cites W2124165778 @default.
- W4309181444 cites W2126308420 @default.
- W4309181444 cites W2130550301 @default.
- W4309181444 cites W2148039105 @default.
- W4309181444 cites W2157672734 @default.
- W4309181444 cites W2158598693 @default.
- W4309181444 cites W2166214412 @default.
- W4309181444 cites W2169812063 @default.
- W4309181444 cites W2229221169 @default.
- W4309181444 cites W2239591911 @default.
- W4309181444 cites W2331649897 @default.
- W4309181444 cites W2432815617 @default.
- W4309181444 cites W2594324975 @default.
- W4309181444 cites W2606065785 @default.
- W4309181444 cites W2802885717 @default.
- W4309181444 cites W2896454609 @default.
- W4309181444 cites W2906455528 @default.
- W4309181444 cites W2950232895 @default.
- W4309181444 cites W2951950648 @default.
- W4309181444 cites W4205202594 @default.
- W4309181444 cites W4225317537 @default.
- W4309181444 cites W4236351289 @default.
- W4309181444 cites W4241803434 @default.
- W4309181444 doi "https://doi.org/10.1038/s41467-022-34475-3" @default.
- W4309181444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36369175" @default.
- W4309181444 hasPublicationYear "2022" @default.
- W4309181444 type Work @default.
- W4309181444 citedByCount "3" @default.
- W4309181444 countsByYear W43091814442023 @default.
- W4309181444 crossrefType "journal-article" @default.
- W4309181444 hasAuthorship W4309181444A5001459507 @default.
- W4309181444 hasAuthorship W4309181444A5002187739 @default.
- W4309181444 hasAuthorship W4309181444A5003191912 @default.
- W4309181444 hasAuthorship W4309181444A5003460678 @default.
- W4309181444 hasAuthorship W4309181444A5005885147 @default.
- W4309181444 hasAuthorship W4309181444A5006198216 @default.
- W4309181444 hasAuthorship W4309181444A5006977278 @default.
- W4309181444 hasAuthorship W4309181444A5013399255 @default.
- W4309181444 hasAuthorship W4309181444A5020235495 @default.
- W4309181444 hasAuthorship W4309181444A5020635446 @default.
- W4309181444 hasAuthorship W4309181444A5021281252 @default.
- W4309181444 hasAuthorship W4309181444A5028575450 @default.
- W4309181444 hasAuthorship W4309181444A5037601897 @default.
- W4309181444 hasAuthorship W4309181444A5039412398 @default.
- W4309181444 hasAuthorship W4309181444A5045898861 @default.
- W4309181444 hasAuthorship W4309181444A5047367423 @default.
- W4309181444 hasAuthorship W4309181444A5049493093 @default.
- W4309181444 hasAuthorship W4309181444A5063393036 @default.