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- W4309195008 abstract "Rapid exploration of chemical space in Medicinal Chemistry projects is a demanding exercise that requires a steadfast approach and commitment to synthetic strategies that increase the success rate for desired compounds to answer a hypothesis. High-Throughput Experimentation (HTE) has proven to increase this success rate by directly evaluating project intermediates with pharmaceutically relevant building blocks in microscale quantities across a diverse chemical reaction space in parallel. This approach enables both the synthesis route and a blueprint for the scalability of the successful reactions. Herein, we present examples of the application of High-Throughput Chemistry (HTC) to Medicinal Chemistry projects spanning route scouting, parallel synthesis, and HTE coupled with other technologies such as flow and automation." @default.
- W4309195008 created "2022-11-24" @default.
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- W4309195008 date "2022-11-15" @default.
- W4309195008 modified "2023-09-27" @default.
- W4309195008 title "Applications of High Throughput Chemistry to Medicinal Chemistry" @default.
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- W4309195008 doi "https://doi.org/10.1021/bk-2022-1420.ch001" @default.
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