FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309200153> ?p ?o ?g. }

• W4309200153 endingPage "114921" @default.
• W4309200153 startingPage "114921" @default.
• W4309200153 abstract "Antibacterial resistance is a healthcare burden. Among Gram-negative bacteria, Pseudomonas aeruginosa belongs to the first list of antibiotic-resistant priority pathogens described by the World Health Organization. Formerly Pseudomonas pseudomallei, Burkholderia pseudomallei, responsible for melioidosis, is considered as a potential bioterrorist weapon by the Centers of Diseases Control and Prevention. We are interested in the development of new ways to combat these bacteria, targeted due to their high level of resistance to antibiotics via a lack of membrane permeability or efflux. Using iron transport systems is a promising strategy to bypass the bacteria cell membrane and restore the activity of conventional antibiotics such as ciprofloxacin. Specific outer membrane receptors are necessary to most microbes as they allow iron uptake, essential for their survival through siderophore-dependent mechanisms. These systems may allow the introduction of antibacterial agents, chemically coupled to a natural or synthetic siderophore molecule to form siderophore-antibiotic conjugates. In this work, we describe the synthesis of six new siderophore analog-ciprofloxacin conjugates including cleavable linker or not. The siderophore analogs correspond to a mono-catechol or a hydroxypyridinone moiety recognized by both Pseudomonas and Burkholderia species. Physico-chemical studies showed that (i) conjugates were unable to interact or cross the membrane by passive diffusion and (ii) conjugates with cleavable linker are stable in physiologic environment. Biological evaluations have highlighted a promising compound 2d, bearing an hydroxypyridinone moiety with a cleavable linker, active on a large panel of strains of Pseudomonas aeruginosa, Burkholderia pseudomallei and Burkholderia thailandensis without toxicity observed in vitro." @default.
• W4309200153 created "2022-11-24" @default.
• W4309200153 creator A5002627230 @default.
• W4309200153 creator A5016618815 @default.
• W4309200153 creator A5016747979 @default.
• W4309200153 creator A5027662926 @default.
• W4309200153 creator A5036646865 @default.
• W4309200153 creator A5042790834 @default.
• W4309200153 creator A5051134428 @default.
• W4309200153 creator A5059784605 @default.
• W4309200153 creator A5061635410 @default.
• W4309200153 creator A5068864765 @default.
• W4309200153 creator A5082994905 @default.
• W4309200153 date "2023-01-01" @default.
• W4309200153 modified "2023-10-16" @default.
• W4309200153 title "Synthesis and study of new siderophore analog-ciprofloxacin conjugates with antibiotic activities against Pseudomonas aeruginosa and Burkholderia spp." @default.
• W4309200153 cites W149224787 @default.
• W4309200153 cites W1969693482 @default.
• W4309200153 cites W1972122276 @default.
• W4309200153 cites W1989842308 @default.
• W4309200153 cites W2000222874 @default.
• W4309200153 cites W2000870210 @default.
• W4309200153 cites W2002865102 @default.
• W4309200153 cites W2004696942 @default.
• W4309200153 cites W2005091504 @default.
• W4309200153 cites W2011884743 @default.
• W4309200153 cites W2031458021 @default.
• W4309200153 cites W2034624108 @default.
• W4309200153 cites W2044865268 @default.
• W4309200153 cites W2073102164 @default.
• W4309200153 cites W2075032094 @default.
• W4309200153 cites W2080095202 @default.
• W4309200153 cites W2082864588 @default.
• W4309200153 cites W2099143902 @default.
• W4309200153 cites W2114452954 @default.
• W4309200153 cites W2126270875 @default.
• W4309200153 cites W2130875594 @default.
• W4309200153 cites W2136016120 @default.
• W4309200153 cites W2137405283 @default.
• W4309200153 cites W2141570886 @default.
• W4309200153 cites W2150754866 @default.
• W4309200153 cites W2161425804 @default.
• W4309200153 cites W2169641796 @default.
• W4309200153 cites W2235609472 @default.
• W4309200153 cites W2290990628 @default.
• W4309200153 cites W2407415576 @default.
• W4309200153 cites W2419509696 @default.
• W4309200153 cites W2489287057 @default.
• W4309200153 cites W2548630962 @default.
• W4309200153 cites W2589067530 @default.
• W4309200153 cites W2606942706 @default.
• W4309200153 cites W2619208761 @default.
• W4309200153 cites W2622656853 @default.
• W4309200153 cites W2766395453 @default.
• W4309200153 cites W2790881225 @default.
• W4309200153 cites W2806849503 @default.
• W4309200153 cites W2810459797 @default.
• W4309200153 cites W2886010441 @default.
• W4309200153 cites W2981827546 @default.
• W4309200153 cites W2997385412 @default.
• W4309200153 cites W2999398902 @default.
• W4309200153 cites W3096281257 @default.
• W4309200153 cites W3112105013 @default.
• W4309200153 cites W3137122686 @default.
• W4309200153 cites W4206677002 @default.
• W4309200153 cites W4211084778 @default.
• W4309200153 cites W4319052970 @default.
• W4309200153 cites W79109269 @default.
• W4309200153 doi "https://doi.org/10.1016/j.ejmech.2022.114921" @default.
• W4309200153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36399876" @default.
• W4309200153 hasPublicationYear "2023" @default.
• W4309200153 type Work @default.
• W4309200153 citedByCount "2" @default.
• W4309200153 countsByYear W43092001532023 @default.
• W4309200153 crossrefType "journal-article" @default.
• W4309200153 hasAuthorship W4309200153A5002627230 @default.
• W4309200153 hasAuthorship W4309200153A5016618815 @default.
• W4309200153 hasAuthorship W4309200153A5016747979 @default.
• W4309200153 hasAuthorship W4309200153A5027662926 @default.
• W4309200153 hasAuthorship W4309200153A5036646865 @default.
• W4309200153 hasAuthorship W4309200153A5042790834 @default.
• W4309200153 hasAuthorship W4309200153A5051134428 @default.
• W4309200153 hasAuthorship W4309200153A5059784605 @default.
• W4309200153 hasAuthorship W4309200153A5061635410 @default.
• W4309200153 hasAuthorship W4309200153A5068864765 @default.
• W4309200153 hasAuthorship W4309200153A5082994905 @default.
• W4309200153 hasConcept C104317684 @default.
• W4309200153 hasConcept C108319773 @default.
• W4309200153 hasConcept C111919701 @default.
• W4309200153 hasConcept C185592680 @default.
• W4309200153 hasConcept C200082930 @default.
• W4309200153 hasConcept C2777637488 @default.
• W4309200153 hasConcept C2778512257 @default.
• W4309200153 hasConcept C2779110727 @default.
• W4309200153 hasConcept C2780557392 @default.
• W4309200153 hasConcept C2780855054 @default.
• W4309200153 hasConcept C2781463711 @default.
• W4309200153 hasConcept C41008148 @default.

• next