Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309202451> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4309202451 endingPage "392" @default.
- W4309202451 startingPage "385" @default.
- W4309202451 abstract "BACKGROUND: Translational research using laboratory animals aimed at revealing the features of the pathogenesis of Parkinsons disease serve as a tool for finding new therapeutic strategies.
 AIM: Was to investigate the effects of human lactoferrin (a multifunctional globular glycoprotein) on behavior the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice as the model of dopaminergic neurons loss.
 MATERIALS AND METHODS: Nigrostriatal dopaminergic injury was induced by single administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (40 mg/kg) to five-month-old C57Bl/6 mice. Behavioral functions were assessed in the open field and rotarod tests and by the stride length analysis.
 RESULTS: Preliminary administration of lactoferrin resulted in a significant reduction in the severity of nervous system lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The positive effect of lactoferrin on the exploratory behavior of animals disturbed by neurotoxin, depending on the time of administration, was revealed. Exogenous protein with double preliminary administration had a protective effect on the change in body weight of mice after acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. This suggests a reduction in systemic toxic effects against the background of lactoferrin therapy.
 CONCLUSION: The results obtained indicate the possibility of the potential use of lactoferrin as a promising therapeutic agent in the treatment of neurodegenerative diseases." @default.
- W4309202451 created "2022-11-24" @default.
- W4309202451 creator A5000239857 @default.
- W4309202451 creator A5022988380 @default.
- W4309202451 creator A5088501282 @default.
- W4309202451 date "2022-11-17" @default.
- W4309202451 modified "2023-09-26" @default.
- W4309202451 title "Effects of human lactoferrin under conditions of neurotoxic exposure: experimental research" @default.
- W4309202451 cites W1510211954 @default.
- W4309202451 cites W1979755786 @default.
- W4309202451 cites W2018932383 @default.
- W4309202451 cites W2022911097 @default.
- W4309202451 cites W2074421138 @default.
- W4309202451 cites W2074565049 @default.
- W4309202451 cites W2104419150 @default.
- W4309202451 cites W2114049362 @default.
- W4309202451 cites W2145913238 @default.
- W4309202451 cites W2147352493 @default.
- W4309202451 cites W2155414406 @default.
- W4309202451 cites W2415859941 @default.
- W4309202451 cites W2587017561 @default.
- W4309202451 cites W2804318423 @default.
- W4309202451 cites W2906111512 @default.
- W4309202451 cites W2969463304 @default.
- W4309202451 cites W3038523604 @default.
- W4309202451 cites W3114952116 @default.
- W4309202451 cites W3187434157 @default.
- W4309202451 cites W4296312488 @default.
- W4309202451 cites W62603772 @default.
- W4309202451 doi "https://doi.org/10.17816/rmmar111944" @default.
- W4309202451 hasPublicationYear "2022" @default.
- W4309202451 type Work @default.
- W4309202451 citedByCount "0" @default.
- W4309202451 crossrefType "journal-article" @default.
- W4309202451 hasAuthorship W4309202451A5000239857 @default.
- W4309202451 hasAuthorship W4309202451A5022988380 @default.
- W4309202451 hasAuthorship W4309202451A5088501282 @default.
- W4309202451 hasBestOaLocation W43092024511 @default.
- W4309202451 hasConcept C126322002 @default.
- W4309202451 hasConcept C137183658 @default.
- W4309202451 hasConcept C150903083 @default.
- W4309202451 hasConcept C185592680 @default.
- W4309202451 hasConcept C207001950 @default.
- W4309202451 hasConcept C25938499 @default.
- W4309202451 hasConcept C2778674702 @default.
- W4309202451 hasConcept C2779134260 @default.
- W4309202451 hasConcept C2779170986 @default.
- W4309202451 hasConcept C2779734285 @default.
- W4309202451 hasConcept C2780358027 @default.
- W4309202451 hasConcept C513476851 @default.
- W4309202451 hasConcept C55493867 @default.
- W4309202451 hasConcept C71924100 @default.
- W4309202451 hasConcept C86803240 @default.
- W4309202451 hasConcept C98274493 @default.
- W4309202451 hasConceptScore W4309202451C126322002 @default.
- W4309202451 hasConceptScore W4309202451C137183658 @default.
- W4309202451 hasConceptScore W4309202451C150903083 @default.
- W4309202451 hasConceptScore W4309202451C185592680 @default.
- W4309202451 hasConceptScore W4309202451C207001950 @default.
- W4309202451 hasConceptScore W4309202451C25938499 @default.
- W4309202451 hasConceptScore W4309202451C2778674702 @default.
- W4309202451 hasConceptScore W4309202451C2779134260 @default.
- W4309202451 hasConceptScore W4309202451C2779170986 @default.
- W4309202451 hasConceptScore W4309202451C2779734285 @default.
- W4309202451 hasConceptScore W4309202451C2780358027 @default.
- W4309202451 hasConceptScore W4309202451C513476851 @default.
- W4309202451 hasConceptScore W4309202451C55493867 @default.
- W4309202451 hasConceptScore W4309202451C71924100 @default.
- W4309202451 hasConceptScore W4309202451C86803240 @default.
- W4309202451 hasConceptScore W4309202451C98274493 @default.
- W4309202451 hasIssue "4" @default.
- W4309202451 hasLocation W43092024511 @default.
- W4309202451 hasOpenAccess W4309202451 @default.
- W4309202451 hasPrimaryLocation W43092024511 @default.
- W4309202451 hasRelatedWork W146225759 @default.
- W4309202451 hasRelatedWork W2048338747 @default.
- W4309202451 hasRelatedWork W2049832980 @default.
- W4309202451 hasRelatedWork W2062605045 @default.
- W4309202451 hasRelatedWork W2078854974 @default.
- W4309202451 hasRelatedWork W208713770 @default.
- W4309202451 hasRelatedWork W2372974288 @default.
- W4309202451 hasRelatedWork W2373966921 @default.
- W4309202451 hasRelatedWork W2608675936 @default.
- W4309202451 hasRelatedWork W4281259865 @default.
- W4309202451 hasVolume "41" @default.
- W4309202451 isParatext "false" @default.
- W4309202451 isRetracted "false" @default.
- W4309202451 workType "article" @default.