Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309204047> ?p ?o ?g. }
- W4309204047 endingPage "194898" @default.
- W4309204047 startingPage "194898" @default.
- W4309204047 abstract "Histone epigenetic modifications are chemical modification changes to histone amino acid residues that modulate gene expression without altering the DNA sequence. As both the phenotypic and causal factors, cardiac metabolism disorder exacerbates mitochondrial ATP generation deficiency, thus promoting pathological cardiac hypertrophy. Moreover, several concomitant metabolic substrates also promote the expression of hypertrophy-responsive genes via regulating histone modifications as substrates or enzyme-modifiers, indicating their dual roles as metabolic and epigenetic regulators. This review focuses on the cardiac acetyl-CoA-dependent histone acetylation, NAD+-dependent SIRT-mediated deacetylation, FAD+-dependent LSD-mediated, and α-KG-dependent JMJD-mediated demethylation after briefly addressing the pathological and physiological cardiac energy metabolism. Besides using an iceberg model to explain the dual role of metabolic substrates as both metabolic and epigenetic regulators, we also put forward that the therapeutic supplementation of metabolic substrates is promising to blunt HF via re-establishing histone modifications." @default.
- W4309204047 created "2022-11-24" @default.
- W4309204047 creator A5008694136 @default.
- W4309204047 creator A5008722057 @default.
- W4309204047 creator A5011279643 @default.
- W4309204047 creator A5031230437 @default.
- W4309204047 creator A5068303855 @default.
- W4309204047 creator A5070179340 @default.
- W4309204047 date "2023-03-01" @default.
- W4309204047 modified "2023-10-17" @default.
- W4309204047 title "Metabolic substrates, histone modifications, and heart failure" @default.
- W4309204047 cites W1553155385 @default.
- W4309204047 cites W1905930372 @default.
- W4309204047 cites W1916910865 @default.
- W4309204047 cites W1930624269 @default.
- W4309204047 cites W1932780354 @default.
- W4309204047 cites W1964201475 @default.
- W4309204047 cites W1965562151 @default.
- W4309204047 cites W1978294146 @default.
- W4309204047 cites W1982111104 @default.
- W4309204047 cites W1984942409 @default.
- W4309204047 cites W1991863384 @default.
- W4309204047 cites W1995338702 @default.
- W4309204047 cites W1998562191 @default.
- W4309204047 cites W2007684630 @default.
- W4309204047 cites W2008659365 @default.
- W4309204047 cites W2025668535 @default.
- W4309204047 cites W2032934478 @default.
- W4309204047 cites W2036083342 @default.
- W4309204047 cites W2053089892 @default.
- W4309204047 cites W2054643318 @default.
- W4309204047 cites W2058104615 @default.
- W4309204047 cites W2070100980 @default.
- W4309204047 cites W2089179674 @default.
- W4309204047 cites W2091034186 @default.
- W4309204047 cites W2102186262 @default.
- W4309204047 cites W2104852749 @default.
- W4309204047 cites W2105583461 @default.
- W4309204047 cites W2112395856 @default.
- W4309204047 cites W2113564565 @default.
- W4309204047 cites W2114803943 @default.
- W4309204047 cites W2115978936 @default.
- W4309204047 cites W2128956618 @default.
- W4309204047 cites W2129558711 @default.
- W4309204047 cites W2131860315 @default.
- W4309204047 cites W2139140534 @default.
- W4309204047 cites W2150738902 @default.
- W4309204047 cites W2161850894 @default.
- W4309204047 cites W2532913608 @default.
- W4309204047 cites W2552184863 @default.
- W4309204047 cites W2562153854 @default.
- W4309204047 cites W2593574515 @default.
- W4309204047 cites W2601144754 @default.
- W4309204047 cites W2616165921 @default.
- W4309204047 cites W2744583165 @default.
- W4309204047 cites W2753846719 @default.
- W4309204047 cites W2765303057 @default.
- W4309204047 cites W2770110700 @default.
- W4309204047 cites W2784290418 @default.
- W4309204047 cites W2790649390 @default.
- W4309204047 cites W2793579688 @default.
- W4309204047 cites W2794296036 @default.
- W4309204047 cites W2801050754 @default.
- W4309204047 cites W2803940480 @default.
- W4309204047 cites W2809295497 @default.
- W4309204047 cites W2901071040 @default.
- W4309204047 cites W2902786420 @default.
- W4309204047 cites W2925036255 @default.
- W4309204047 cites W2947216648 @default.
- W4309204047 cites W2955248709 @default.
- W4309204047 cites W2955543783 @default.
- W4309204047 cites W2956570670 @default.
- W4309204047 cites W2966010975 @default.
- W4309204047 cites W2982216374 @default.
- W4309204047 cites W2986012157 @default.
- W4309204047 cites W3010552936 @default.
- W4309204047 cites W3014365963 @default.
- W4309204047 cites W3018214921 @default.
- W4309204047 cites W3018753833 @default.
- W4309204047 cites W3023560145 @default.
- W4309204047 cites W3031462206 @default.
- W4309204047 cites W3034816692 @default.
- W4309204047 cites W3042750016 @default.
- W4309204047 cites W3045660571 @default.
- W4309204047 cites W3082569921 @default.
- W4309204047 cites W3092932642 @default.
- W4309204047 cites W3110967658 @default.
- W4309204047 cites W3120594160 @default.
- W4309204047 cites W3127922419 @default.
- W4309204047 cites W3128937625 @default.
- W4309204047 cites W3136200267 @default.
- W4309204047 cites W3156269357 @default.
- W4309204047 cites W3157780595 @default.
- W4309204047 cites W3164393380 @default.
- W4309204047 cites W3164834953 @default.
- W4309204047 cites W3165482261 @default.
- W4309204047 cites W3190249897 @default.
- W4309204047 cites W3210142854 @default.