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- W4309205166 endingPage "103430" @default.
- W4309205166 startingPage "103430" @default.
- W4309205166 abstract "DNA double-strand breaks (DSBs) are lesions that arise frequently from exposure to damaging agents as well as from ongoing physiological DNA transactions. Mis-repair of DSBs leads to rearrangements and structural variations in chromosomes, including insertions, deletions, and translocations implicated in disease. The DNA damage response (DDR) limits pathologic mutations and large-scale chromosome rearrangements. DSB repair initiates in 2D at DNA lesions with the stepwise recruitment of repair proteins and local chromatin remodeling which facilitates break accessibility. More complex structures are then formed via protein assembly into nanodomains and via genome folding into chromatin loops. Subsequently, 3D reorganization of DSBs is guided by clustering forces which drive the assembly of repair domains harboring multiple lesions. These domains are further stabilized and insulated into condensates via liquid-liquid phase-separation. Here, we discuss the benefits and risks associated with this 3D reorganization of the broken genome." @default.
- W4309205166 created "2022-11-24" @default.
- W4309205166 creator A5031782217 @default.
- W4309205166 creator A5066167912 @default.
- W4309205166 date "2023-01-01" @default.
- W4309205166 modified "2023-10-15" @default.
- W4309205166 title "Double-strand break repair and mis-repair in 3D" @default.
- W4309205166 cites W1509538618 @default.
- W4309205166 cites W1511554465 @default.
- W4309205166 cites W1573323739 @default.
- W4309205166 cites W1602963387 @default.
- W4309205166 cites W1918633965 @default.
- W4309205166 cites W1922847255 @default.
- W4309205166 cites W1963634449 @default.
- W4309205166 cites W1965619398 @default.
- W4309205166 cites W1971045116 @default.
- W4309205166 cites W1972984145 @default.
- W4309205166 cites W1973062929 @default.
- W4309205166 cites W1982308446 @default.
- W4309205166 cites W1985775217 @default.
- W4309205166 cites W1997228602 @default.
- W4309205166 cites W1997303368 @default.
- W4309205166 cites W1997462031 @default.
- W4309205166 cites W1999541392 @default.
- W4309205166 cites W1999644099 @default.
- W4309205166 cites W2000136433 @default.
- W4309205166 cites W2021870890 @default.
- W4309205166 cites W2022855448 @default.
- W4309205166 cites W2024754737 @default.
- W4309205166 cites W2026755238 @default.
- W4309205166 cites W2030545747 @default.
- W4309205166 cites W2031375145 @default.
- W4309205166 cites W2036663020 @default.
- W4309205166 cites W2041251646 @default.
- W4309205166 cites W2041389422 @default.
- W4309205166 cites W2041611886 @default.
- W4309205166 cites W2041656651 @default.
- W4309205166 cites W2043943343 @default.
- W4309205166 cites W2044868606 @default.
- W4309205166 cites W2054560592 @default.
- W4309205166 cites W2054646144 @default.
- W4309205166 cites W2060485452 @default.
- W4309205166 cites W2061015334 @default.
- W4309205166 cites W2064537118 @default.
- W4309205166 cites W2066999586 @default.
- W4309205166 cites W2068973408 @default.
- W4309205166 cites W2070021921 @default.
- W4309205166 cites W2070509435 @default.
- W4309205166 cites W2070660722 @default.
- W4309205166 cites W2073026107 @default.
- W4309205166 cites W2073992277 @default.
- W4309205166 cites W2080479776 @default.
- W4309205166 cites W2081209093 @default.
- W4309205166 cites W2084969545 @default.
- W4309205166 cites W2089456325 @default.
- W4309205166 cites W2090037139 @default.
- W4309205166 cites W2091243328 @default.
- W4309205166 cites W2094770469 @default.
- W4309205166 cites W2097027640 @default.
- W4309205166 cites W2097627856 @default.
- W4309205166 cites W2098278940 @default.
- W4309205166 cites W2104003823 @default.
- W4309205166 cites W2104400024 @default.
- W4309205166 cites W2108615748 @default.
- W4309205166 cites W2112348939 @default.
- W4309205166 cites W2116302199 @default.
- W4309205166 cites W2121484182 @default.
- W4309205166 cites W2122680160 @default.
- W4309205166 cites W2123110782 @default.
- W4309205166 cites W2126684428 @default.
- W4309205166 cites W2131511000 @default.
- W4309205166 cites W2131978108 @default.
- W4309205166 cites W2132396299 @default.
- W4309205166 cites W2135922376 @default.
- W4309205166 cites W2144252460 @default.
- W4309205166 cites W2145506563 @default.
- W4309205166 cites W2146427646 @default.
- W4309205166 cites W2150587707 @default.
- W4309205166 cites W2150860983 @default.
- W4309205166 cites W2152440925 @default.
- W4309205166 cites W2152456839 @default.
- W4309205166 cites W2161212572 @default.
- W4309205166 cites W2161458929 @default.
- W4309205166 cites W2164648414 @default.
- W4309205166 cites W2164995160 @default.
- W4309205166 cites W2167365794 @default.
- W4309205166 cites W2168493348 @default.
- W4309205166 cites W2169741450 @default.
- W4309205166 cites W2170285819 @default.
- W4309205166 cites W2172400873 @default.
- W4309205166 cites W2180452931 @default.
- W4309205166 cites W2203229763 @default.
- W4309205166 cites W2222857089 @default.
- W4309205166 cites W2253035633 @default.
- W4309205166 cites W2256829667 @default.
- W4309205166 cites W2257612787 @default.
- W4309205166 cites W2261191534 @default.
- W4309205166 cites W2271817176 @default.