FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309222004> ?p ?o ?g. }

• W4309222004 endingPage "1175" @default.
• W4309222004 startingPage "1175" @default.
• W4309222004 abstract "Endometriosis is a chronic condition that affects women of child-bearing age. Since the etiology and pathogenesis of endometriosis have not been fully elucidated, it is important to investigate the mechanisms that lead to the deterioration of endometriosis.In this study, the transcriptome data of patients with normal, mild, and severe endometriosis were examined using the GSE51981 dataset obtained from the Gene Expression Omnibus database. Short Time Series Expression Miner (STEM) was used to screen the genes with continuous expression disorder in the development process, and the core genes were identified by constructing a protein-protein interaction network. The molecular mechanisms of endometriosis were examined using enrichment analysis. Finally, the transcription factors that regulate the core genes were predicted and the comprehensive mechanisms involved in the development of endometriosis were examined.A total of 3,472 differentially expressed genes were identified from the normal, mild, and severe endometriosis samples. These were allocated into 12 modules and HRAS, HSP90AA1, TGFB1, TP53, and UBC were selected as the core genes. Enrichment analysis showed that the genes in modules 6, 7, and 9 were significantly related to oxygen levels, metallic processes, and hormone levels, respectively. Transcription factor prediction analysis showed that TP53 regulates HRAS to participate in immune related signaling pathways. Drug prediction analysis identified 792 drugs that interact with the targeted core genes.This study explored the molecular mechanisms involved in the development of endometriosis and identified potential biomarkers of endometriosis. This data may provide novel targets and research directions for the diagnosis and treatment of endometriosis." @default.
• W4309222004 created "2022-11-24" @default.
• W4309222004 creator A5001530798 @default.
• W4309222004 creator A5003799076 @default.
• W4309222004 creator A5005513706 @default.
• W4309222004 creator A5006737896 @default.
• W4309222004 creator A5041042855 @default.
• W4309222004 creator A5043253835 @default.
• W4309222004 creator A5044064023 @default.
• W4309222004 creator A5061070733 @default.
• W4309222004 creator A5065096711 @default.
• W4309222004 creator A5080429583 @default.
• W4309222004 creator A5089949087 @default.
• W4309222004 date "2022-11-01" @default.
• W4309222004 modified "2023-09-30" @default.
• W4309222004 title "Persistent dysregulation of genes in the development of endometriosis" @default.
• W4309222004 cites W1967487236 @default.
• W4309222004 cites W1987272835 @default.
• W4309222004 cites W2035618305 @default.
• W4309222004 cites W2045030989 @default.
• W4309222004 cites W2054798875 @default.
• W4309222004 cites W2100212794 @default.
• W4309222004 cites W2101142880 @default.
• W4309222004 cites W2117024463 @default.
• W4309222004 cites W2123641868 @default.
• W4309222004 cites W2126781562 @default.
• W4309222004 cites W2131149447 @default.
• W4309222004 cites W2136850043 @default.
• W4309222004 cites W2145383112 @default.
• W4309222004 cites W2155227851 @default.
• W4309222004 cites W2159707944 @default.
• W4309222004 cites W2161081282 @default.
• W4309222004 cites W2161653969 @default.
• W4309222004 cites W2168661398 @default.
• W4309222004 cites W2284803191 @default.
• W4309222004 cites W2393405751 @default.
• W4309222004 cites W2537623931 @default.
• W4309222004 cites W2557283063 @default.
• W4309222004 cites W2588623168 @default.
• W4309222004 cites W2607215535 @default.
• W4309222004 cites W2608139107 @default.
• W4309222004 cites W2613425805 @default.
• W4309222004 cites W2755967472 @default.
• W4309222004 cites W2781407444 @default.
• W4309222004 cites W2788452262 @default.
• W4309222004 cites W2789328831 @default.
• W4309222004 cites W2885886888 @default.
• W4309222004 cites W2941565958 @default.
• W4309222004 cites W2986294785 @default.
• W4309222004 cites W3042542048 @default.
• W4309222004 cites W3202177173 @default.
• W4309222004 cites W3202561929 @default.
• W4309222004 cites W3203653962 @default.
• W4309222004 cites W3205945027 @default.
• W4309222004 cites W3211370918 @default.
• W4309222004 cites W4200387333 @default.
• W4309222004 cites W4205198611 @default.
• W4309222004 cites W4225083785 @default.
• W4309222004 cites W4283451643 @default.
• W4309222004 doi "https://doi.org/10.21037/atm-22-4806" @default.
• W4309222004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36467354" @default.
• W4309222004 hasPublicationYear "2022" @default.
• W4309222004 type Work @default.
• W4309222004 citedByCount "1" @default.
• W4309222004 countsByYear W43092220042023 @default.
• W4309222004 crossrefType "journal-article" @default.
• W4309222004 hasAuthorship W4309222004A5001530798 @default.
• W4309222004 hasAuthorship W4309222004A5003799076 @default.
• W4309222004 hasAuthorship W4309222004A5005513706 @default.
• W4309222004 hasAuthorship W4309222004A5006737896 @default.
• W4309222004 hasAuthorship W4309222004A5041042855 @default.
• W4309222004 hasAuthorship W4309222004A5043253835 @default.
• W4309222004 hasAuthorship W4309222004A5044064023 @default.
• W4309222004 hasAuthorship W4309222004A5061070733 @default.
• W4309222004 hasAuthorship W4309222004A5065096711 @default.
• W4309222004 hasAuthorship W4309222004A5080429583 @default.
• W4309222004 hasAuthorship W4309222004A5089949087 @default.
• W4309222004 hasBestOaLocation W43092220041 @default.
• W4309222004 hasConcept C104317684 @default.
• W4309222004 hasConcept C1167327 @default.
• W4309222004 hasConcept C126322002 @default.
• W4309222004 hasConcept C150194340 @default.
• W4309222004 hasConcept C162317418 @default.
• W4309222004 hasConcept C2779522080 @default.
• W4309222004 hasConcept C2780035454 @default.
• W4309222004 hasConcept C2781187634 @default.
• W4309222004 hasConcept C501734568 @default.
• W4309222004 hasConcept C54355233 @default.
• W4309222004 hasConcept C60644358 @default.
• W4309222004 hasConcept C64903051 @default.
• W4309222004 hasConcept C70721500 @default.
• W4309222004 hasConcept C71924100 @default.
• W4309222004 hasConcept C86339819 @default.
• W4309222004 hasConcept C86803240 @default.
• W4309222004 hasConcept C98274493 @default.
• W4309222004 hasConceptScore W4309222004C104317684 @default.
• W4309222004 hasConceptScore W4309222004C1167327 @default.
• W4309222004 hasConceptScore W4309222004C126322002 @default.

• next