Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309223542> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4309223542 abstract "Abstract Background The last few decades have seen the approval of many new treatment options for Relapsing-Remitting Multiple Sclerosis (RRMS), as well as advances in diagnostic methodology and criteria. These developments have greatly improved the available treatment options for today’s Relapsing-Remitting Multiple Sclerosis patients. This increased availability of disease modifying treatments, however, has implications for clinical trial design in this therapeutic area. The availability of better diagnostics and more treatment options have not only contributed to progressively decreasing relapse rates in clinical trial populations but have also resulted in the evolution of control arms, as it is often no longer sufficient to show improvement from placebo. As a result, not only have clinical trials become longer and more expensive but comparing the results to those of “historical” trials has also become more difficult. Methods In order to aid design of clinical trials in RRMS, we have developed a simulator called MS TreatSim which can simulate the response of customizable, heterogeneous groups of patients to four common Relapsing-Remitting Multiple Sclerosis treatment options. MS TreatSim combines a mechanistic, agent-based model of the immune-based etiology of RRMS with a simulation framework for the generation and virtual trial simulation of populations of digital patients. Results In this study, the product was first applied to generate diverse populations of digital patients. Then we applied it to reproduce a phase III trial of natalizumab as published 15 years ago as a use case. Within the limitations of synthetic data availability, the results showed the potential of applying MS TreatSim to recreate the relapse rates of this historical trial of natalizumab. Conclusions MS TreatSim’s synergistic combination of a mechanistic model with a clinical trial simulation framework is a tool that may advance model-based clinical trial design." @default.
- W4309223542 created "2022-11-24" @default.
- W4309223542 creator A5004880055 @default.
- W4309223542 creator A5011699032 @default.
- W4309223542 creator A5018848503 @default.
- W4309223542 creator A5062313944 @default.
- W4309223542 date "2022-11-15" @default.
- W4309223542 modified "2023-09-30" @default.
- W4309223542 title "In silico clinical trials for relapsing-remitting multiple sclerosis with MS TreatSim" @default.
- W4309223542 cites W1623768750 @default.
- W4309223542 cites W2084706776 @default.
- W4309223542 cites W2103758700 @default.
- W4309223542 cites W2172275426 @default.
- W4309223542 cites W2346839593 @default.
- W4309223542 cites W2460433998 @default.
- W4309223542 cites W2777074421 @default.
- W4309223542 cites W2896014118 @default.
- W4309223542 cites W2917118951 @default.
- W4309223542 cites W2944092461 @default.
- W4309223542 cites W2965512201 @default.
- W4309223542 cites W2994705677 @default.
- W4309223542 cites W3000380019 @default.
- W4309223542 cites W3011023930 @default.
- W4309223542 cites W3014272379 @default.
- W4309223542 cites W3036377076 @default.
- W4309223542 cites W3090130519 @default.
- W4309223542 cites W3093920803 @default.
- W4309223542 cites W3107309763 @default.
- W4309223542 cites W3112174179 @default.
- W4309223542 cites W3112654906 @default.
- W4309223542 cites W3112837331 @default.
- W4309223542 cites W3157911739 @default.
- W4309223542 cites W3202367516 @default.
- W4309223542 cites W3208091845 @default.
- W4309223542 cites W4205972999 @default.
- W4309223542 cites W4210308892 @default.
- W4309223542 doi "https://doi.org/10.1186/s12911-022-02034-x" @default.
- W4309223542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36380294" @default.
- W4309223542 hasPublicationYear "2022" @default.
- W4309223542 type Work @default.
- W4309223542 citedByCount "3" @default.
- W4309223542 countsByYear W43092235422023 @default.
- W4309223542 crossrefType "journal-article" @default.
- W4309223542 hasAuthorship W4309223542A5004880055 @default.
- W4309223542 hasAuthorship W4309223542A5011699032 @default.
- W4309223542 hasAuthorship W4309223542A5018848503 @default.
- W4309223542 hasAuthorship W4309223542A5062313944 @default.
- W4309223542 hasBestOaLocation W43092235421 @default.
- W4309223542 hasConcept C126322002 @default.
- W4309223542 hasConcept C142724271 @default.
- W4309223542 hasConcept C177713679 @default.
- W4309223542 hasConcept C203014093 @default.
- W4309223542 hasConcept C204787440 @default.
- W4309223542 hasConcept C27081682 @default.
- W4309223542 hasConcept C2776036978 @default.
- W4309223542 hasConcept C2777703276 @default.
- W4309223542 hasConcept C2778577042 @default.
- W4309223542 hasConcept C2779134260 @default.
- W4309223542 hasConcept C2780640218 @default.
- W4309223542 hasConcept C2781004633 @default.
- W4309223542 hasConcept C3020694758 @default.
- W4309223542 hasConcept C535046627 @default.
- W4309223542 hasConcept C71924100 @default.
- W4309223542 hasConceptScore W4309223542C126322002 @default.
- W4309223542 hasConceptScore W4309223542C142724271 @default.
- W4309223542 hasConceptScore W4309223542C177713679 @default.
- W4309223542 hasConceptScore W4309223542C203014093 @default.
- W4309223542 hasConceptScore W4309223542C204787440 @default.
- W4309223542 hasConceptScore W4309223542C27081682 @default.
- W4309223542 hasConceptScore W4309223542C2776036978 @default.
- W4309223542 hasConceptScore W4309223542C2777703276 @default.
- W4309223542 hasConceptScore W4309223542C2778577042 @default.
- W4309223542 hasConceptScore W4309223542C2779134260 @default.
- W4309223542 hasConceptScore W4309223542C2780640218 @default.
- W4309223542 hasConceptScore W4309223542C2781004633 @default.
- W4309223542 hasConceptScore W4309223542C3020694758 @default.
- W4309223542 hasConceptScore W4309223542C535046627 @default.
- W4309223542 hasConceptScore W4309223542C71924100 @default.
- W4309223542 hasIssue "S6" @default.
- W4309223542 hasLocation W43092235421 @default.
- W4309223542 hasLocation W43092235422 @default.
- W4309223542 hasLocation W43092235423 @default.
- W4309223542 hasOpenAccess W4309223542 @default.
- W4309223542 hasPrimaryLocation W43092235421 @default.
- W4309223542 hasRelatedWork W1532617462 @default.
- W4309223542 hasRelatedWork W2001220614 @default.
- W4309223542 hasRelatedWork W2002450319 @default.
- W4309223542 hasRelatedWork W2059346471 @default.
- W4309223542 hasRelatedWork W2083083635 @default.
- W4309223542 hasRelatedWork W2398000750 @default.
- W4309223542 hasRelatedWork W2593513173 @default.
- W4309223542 hasRelatedWork W3030177861 @default.
- W4309223542 hasRelatedWork W4235416836 @default.
- W4309223542 hasRelatedWork W4315700955 @default.
- W4309223542 hasVolume "22" @default.
- W4309223542 isParatext "false" @default.
- W4309223542 isRetracted "false" @default.
- W4309223542 workType "article" @default.