FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309227831> ?p ?o ?g. }

• W4309227831 abstract "Abstract RNA-Seq is widely used to capture transcriptome dynamics across tissues from different biological entities even across biological conditions, with the aim of understanding the contribution of gene activities to phenotypes of biosamples. However, due to variation from tissues and biological entities (or other biological conditions), joint analysis of bulk RNA expression profiles across multiple tissues from a number of biological entities to achieve the aim is hindered. Moreover, it is crucial to consider interactions between biological variables. For example, different brain disorders may affect brain regions heterogeneously. Thus, modeling the disorder-region interaction can shed light on the heterogeneity. To address these key challenges, we propose a general and flexible statistical framework based on matrix factorization, named INSIDER ( https://github.com/kai0511/insider ). INSIDER decomposes variation from different biological variables into a shared low-rank latent space. In particular, it considers interactions between biological variables and introduces the elastic net penalty to induce sparsity, thus facilitating interpretation. In the framework, the biological variables and interaction terms can be defined based on the research questions and study design. Besides, it enables us to compute the ‘adjusted’ expression profiles for biological variables that control variation from other biological variables. Lastly, it allows various downstream analyses, such as clustering donors with donor representations, revealing development trajectory in its application to the BrainSpan data, and uncovering mechanisms underlying variables like phenotype and interactions between biological variables (e.g., phenotypes and tissues)." @default.
• W4309227831 created "2022-11-24" @default.
• W4309227831 creator A5010652735 @default.
• W4309227831 creator A5014111636 @default.
• W4309227831 creator A5018516395 @default.
• W4309227831 creator A5055958965 @default.
• W4309227831 creator A5059809752 @default.
• W4309227831 creator A5062317723 @default.
• W4309227831 date "2022-11-13" @default.
• W4309227831 modified "2023-10-14" @default.
• W4309227831 title "INSIDER: Interpretable Sparse Matrix Decomposition for Bulk RNA Expression Data Analysis" @default.
• W4309227831 cites W1698695320 @default.
• W4309227831 cites W1902027874 @default.
• W4309227831 cites W1966262235 @default.
• W4309227831 cites W1981509058 @default.
• W4309227831 cites W1995647101 @default.
• W4309227831 cites W1999299319 @default.
• W4309227831 cites W2007804566 @default.
• W4309227831 cites W2016854025 @default.
• W4309227831 cites W2016948983 @default.
• W4309227831 cites W2018838463 @default.
• W4309227831 cites W2022689242 @default.
• W4309227831 cites W2024165284 @default.
• W4309227831 cites W2032977736 @default.
• W4309227831 cites W2045333811 @default.
• W4309227831 cites W2046711538 @default.
• W4309227831 cites W2075517844 @default.
• W4309227831 cites W2086629023 @default.
• W4309227831 cites W2107665951 @default.
• W4309227831 cites W2116650193 @default.
• W4309227831 cites W2131060185 @default.
• W4309227831 cites W2136787567 @default.
• W4309227831 cites W2154778070 @default.
• W4309227831 cites W2163302580 @default.
• W4309227831 cites W2166158223 @default.
• W4309227831 cites W2166174200 @default.
• W4309227831 cites W2173304983 @default.
• W4309227831 cites W2195649847 @default.
• W4309227831 cites W2210537348 @default.
• W4309227831 cites W2482092413 @default.
• W4309227831 cites W2518536270 @default.
• W4309227831 cites W2767787249 @default.
• W4309227831 cites W2798368076 @default.
• W4309227831 cites W2883806880 @default.
• W4309227831 cites W2886085041 @default.
• W4309227831 cites W2891223523 @default.
• W4309227831 cites W2949755237 @default.
• W4309227831 cites W2950245999 @default.
• W4309227831 cites W2952153616 @default.
• W4309227831 cites W2952574438 @default.
• W4309227831 cites W3014396109 @default.
• W4309227831 cites W3092493138 @default.
• W4309227831 cites W3103867094 @default.
• W4309227831 cites W3112120242 @default.
• W4309227831 cites W3162336038 @default.
• W4309227831 cites W3164235587 @default.
• W4309227831 cites W4225246326 @default.
• W4309227831 cites W4225981439 @default.
• W4309227831 cites W4234063125 @default.
• W4309227831 cites W4294541781 @default.
• W4309227831 doi "https://doi.org/10.1101/2022.11.10.515904" @default.
• W4309227831 hasPublicationYear "2022" @default.
• W4309227831 type Work @default.
• W4309227831 citedByCount "0" @default.
• W4309227831 crossrefType "posted-content" @default.
• W4309227831 hasAuthorship W4309227831A5010652735 @default.
• W4309227831 hasAuthorship W4309227831A5014111636 @default.
• W4309227831 hasAuthorship W4309227831A5018516395 @default.
• W4309227831 hasAuthorship W4309227831A5055958965 @default.
• W4309227831 hasAuthorship W4309227831A5059809752 @default.
• W4309227831 hasAuthorship W4309227831A5062317723 @default.
• W4309227831 hasBestOaLocation W43092278311 @default.
• W4309227831 hasConcept C103278499 @default.
• W4309227831 hasConcept C114614502 @default.
• W4309227831 hasConcept C115961682 @default.
• W4309227831 hasConcept C119857082 @default.
• W4309227831 hasConcept C121332964 @default.
• W4309227831 hasConcept C124101348 @default.
• W4309227831 hasConcept C152671427 @default.
• W4309227831 hasConcept C154945302 @default.
• W4309227831 hasConcept C158693339 @default.
• W4309227831 hasConcept C164226766 @default.
• W4309227831 hasConcept C17744445 @default.
• W4309227831 hasConcept C199360897 @default.
• W4309227831 hasConcept C199539241 @default.
• W4309227831 hasConcept C201797286 @default.
• W4309227831 hasConcept C2778334786 @default.
• W4309227831 hasConcept C2778971194 @default.
• W4309227831 hasConcept C33923547 @default.
• W4309227831 hasConcept C41008148 @default.
• W4309227831 hasConcept C42355184 @default.
• W4309227831 hasConcept C44870925 @default.
• W4309227831 hasConcept C51167844 @default.
• W4309227831 hasConcept C60644358 @default.
• W4309227831 hasConcept C62520636 @default.
• W4309227831 hasConcept C70721500 @default.
• W4309227831 hasConcept C73555534 @default.
• W4309227831 hasConcept C86803240 @default.
• W4309227831 hasConcept C90559484 @default.
• W4309227831 hasConceptScore W4309227831C103278499 @default.

• next