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• W4309230497 abstract "Abstract Selective serotonin reuptake inhibitors (SSRIs) increase serotonin activity in the brain. While they are mostly known for their antidepressant properties, they have been shown to improve visual functions in amblyopia and impact cognitive functions ranging from attention to motivation and sensitivity to reward. Yet, a clear understanding of the specific action of serotonin to each of bottom-up sensory and top-down cognitive control components and their interaction is still missing. To address this question, we characterize, in two adult macaques, the behavioral effects of fluoxetine, a specific SSRI, on visual perception under varying bottom-up (luminosity, distractors) and top-down (uncertainty, reward biases) constraints while they are performing three different visual tasks. We first manipulate target luminosity in a visual detection task, and we show that fluoxetine degrades luminance perceptual thresholds. We then use a target detection task in the presence of spatial distractors, and we show that under fluoxetine, monkeys display both more liberal responses as well as a degraded perceptual spatial resolution. In a last target selection task, involving free choice in the presence of reward biases, we show that monkeys display an increased sensitivity to reward outcome under fluoxetine. In addition, we report that monkeys produce, under fluoxetine, more trials and less aborts, increased pupil size, shorter blink durations, as well as task-dependent changes in reaction times. Overall, while low level vision appears to be degraded by fluoxetine, performance in the visual tasks are maintained under fluoxetine due to enhanced top-down control based on task outcome and reward maximization." @default.
• W4309230497 created "2022-11-24" @default.
• W4309230497 creator A5014323105 @default.
• W4309230497 creator A5079303585 @default.
• W4309230497 date "2022-11-13" @default.
• W4309230497 modified "2023-10-18" @default.
• W4309230497 title "Fluoxetine degrades luminance perceptual thresholds while enhancing motivation and reward sensitivity" @default.
• W4309230497 cites W1523136835 @default.
• W4309230497 cites W1676949008 @default.
• W4309230497 cites W1917352355 @default.
• W4309230497 cites W1960334202 @default.
• W4309230497 cites W1966747636 @default.
• W4309230497 cites W1967578133 @default.
• W4309230497 cites W1968183770 @default.
• W4309230497 cites W1970389483 @default.
• W4309230497 cites W1973763118 @default.
• W4309230497 cites W1984766700 @default.
• W4309230497 cites W1987022586 @default.
• W4309230497 cites W1987739081 @default.
• W4309230497 cites W1989756802 @default.
• W4309230497 cites W1991183604 @default.
• W4309230497 cites W1992103170 @default.
• W4309230497 cites W1995904819 @default.
• W4309230497 cites W1999473774 @default.
• W4309230497 cites W1999557729 @default.
• W4309230497 cites W2001284551 @default.
• W4309230497 cites W2001389318 @default.
• W4309230497 cites W2002766201 @default.
• W4309230497 cites W2002863546 @default.
• W4309230497 cites W2004618821 @default.
• W4309230497 cites W2005759468 @default.
• W4309230497 cites W2007078634 @default.
• W4309230497 cites W2007445647 @default.
• W4309230497 cites W2007709610 @default.
• W4309230497 cites W2008009892 @default.
• W4309230497 cites W2011165558 @default.
• W4309230497 cites W2011667957 @default.
• W4309230497 cites W2011826549 @default.
• W4309230497 cites W2012359728 @default.
• W4309230497 cites W2013940743 @default.
• W4309230497 cites W2014203063 @default.
• W4309230497 cites W2014643576 @default.
• W4309230497 cites W2015724371 @default.
• W4309230497 cites W2017404969 @default.
• W4309230497 cites W2019543892 @default.
• W4309230497 cites W2020771485 @default.
• W4309230497 cites W2026905307 @default.
• W4309230497 cites W2027766226 @default.
• W4309230497 cites W2028947841 @default.
• W4309230497 cites W2030313035 @default.
• W4309230497 cites W2032914713 @default.
• W4309230497 cites W2038752897 @default.
• W4309230497 cites W2041529027 @default.
• W4309230497 cites W2042138823 @default.
• W4309230497 cites W2042880323 @default.
• W4309230497 cites W2043641984 @default.
• W4309230497 cites W2045287840 @default.
• W4309230497 cites W2048425829 @default.
• W4309230497 cites W2049227843 @default.
• W4309230497 cites W2049687820 @default.
• W4309230497 cites W2051423370 @default.
• W4309230497 cites W2055676373 @default.
• W4309230497 cites W2055810716 @default.
• W4309230497 cites W2058207180 @default.
• W4309230497 cites W2065071991 @default.
• W4309230497 cites W2065532796 @default.
• W4309230497 cites W2066607176 @default.
• W4309230497 cites W2073626660 @default.
• W4309230497 cites W2075901584 @default.
• W4309230497 cites W2079695331 @default.
• W4309230497 cites W2080402976 @default.
• W4309230497 cites W2080825784 @default.
• W4309230497 cites W2080894710 @default.
• W4309230497 cites W2083058253 @default.
• W4309230497 cites W2084263936 @default.
• W4309230497 cites W2090298970 @default.
• W4309230497 cites W2093151452 @default.
• W4309230497 cites W2093312203 @default.
• W4309230497 cites W2095315539 @default.
• W4309230497 cites W2102584403 @default.
• W4309230497 cites W2103134052 @default.
• W4309230497 cites W2105154162 @default.
• W4309230497 cites W2108625229 @default.
• W4309230497 cites W2115095583 @default.
• W4309230497 cites W2116725779 @default.
• W4309230497 cites W2117541477 @default.
• W4309230497 cites W2123269313 @default.
• W4309230497 cites W2125405058 @default.
• W4309230497 cites W2125605735 @default.
• W4309230497 cites W2126060089 @default.
• W4309230497 cites W2126449881 @default.
• W4309230497 cites W2138378362 @default.
• W4309230497 cites W2143994941 @default.
• W4309230497 cites W2144764737 @default.
• W4309230497 cites W2148696866 @default.
• W4309230497 cites W2156868152 @default.
• W4309230497 cites W2164650786 @default.
• W4309230497 cites W2164903550 @default.
• W4309230497 cites W2167042400 @default.
• W4309230497 cites W2170969968 @default.

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