Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309231126> ?p ?o ?g. }
- W4309231126 abstract "Abstract In recent years, the development of high-throughput omics technology has greatly promoted the development of biomedicine. However, the poor reproducibility of omics techniques limits its application. It is necessary to use standard reference materials of complex RNAs or proteins to test and calibrate the accuracy and reproducibility of omics workflows. However, the transcriptome and proteome of most cell lines shift during culturing, which limits their applicability to serve as standard samples. In this study, we demonstrated that the human hepatocellular cell line MHCC97H has a very stable transcriptome (R 2 =0.966-0.995) and proteome (R 2 =0.934-0.976 for DDA, R 2 =0.942-0.986 for DIA) after 9 subculturing generations, which allows this stable standard sample to be stably produced on an industrial scale for several decades. Moreover, this stability was maintained across labs and platforms. In sum, our results justified a omics standard reference material and reference datasets for transcriptomic and proteomics research. This helps to further standardize the workflow and data quality of omics techniques and thus promotes the application of omics technology in precision medicine." @default.
- W4309231126 created "2022-11-24" @default.
- W4309231126 creator A5007869766 @default.
- W4309231126 creator A5008247363 @default.
- W4309231126 creator A5012921461 @default.
- W4309231126 creator A5020819058 @default.
- W4309231126 creator A5022686105 @default.
- W4309231126 creator A5028641049 @default.
- W4309231126 creator A5031383697 @default.
- W4309231126 creator A5038172787 @default.
- W4309231126 creator A5043214777 @default.
- W4309231126 creator A5049206710 @default.
- W4309231126 creator A5056530872 @default.
- W4309231126 creator A5066949471 @default.
- W4309231126 creator A5067179209 @default.
- W4309231126 creator A5068046399 @default.
- W4309231126 creator A5073908949 @default.
- W4309231126 date "2022-11-17" @default.
- W4309231126 modified "2023-10-17" @default.
- W4309231126 title "A stable reference human transcriptome and proteome as a standard for reproducible omics experiments" @default.
- W4309231126 cites W1599740911 @default.
- W4309231126 cites W1968063944 @default.
- W4309231126 cites W1973838650 @default.
- W4309231126 cites W1992843897 @default.
- W4309231126 cites W1994994140 @default.
- W4309231126 cites W1995478292 @default.
- W4309231126 cites W1996098588 @default.
- W4309231126 cites W2000798721 @default.
- W4309231126 cites W2027673257 @default.
- W4309231126 cites W2028459415 @default.
- W4309231126 cites W2037199116 @default.
- W4309231126 cites W2043256480 @default.
- W4309231126 cites W2064397275 @default.
- W4309231126 cites W2074871118 @default.
- W4309231126 cites W2088363255 @default.
- W4309231126 cites W2088522202 @default.
- W4309231126 cites W2090182247 @default.
- W4309231126 cites W2121158677 @default.
- W4309231126 cites W2128551987 @default.
- W4309231126 cites W2137586531 @default.
- W4309231126 cites W2151886124 @default.
- W4309231126 cites W2154431984 @default.
- W4309231126 cites W2155173012 @default.
- W4309231126 cites W2160443244 @default.
- W4309231126 cites W2176188079 @default.
- W4309231126 cites W2221358813 @default.
- W4309231126 cites W2413403124 @default.
- W4309231126 cites W2460305440 @default.
- W4309231126 cites W2589200987 @default.
- W4309231126 cites W2603189599 @default.
- W4309231126 cites W2609981313 @default.
- W4309231126 cites W2624605702 @default.
- W4309231126 cites W2765095070 @default.
- W4309231126 cites W2771888931 @default.
- W4309231126 cites W2792874817 @default.
- W4309231126 cites W2912937988 @default.
- W4309231126 cites W2968127546 @default.
- W4309231126 cites W2996038594 @default.
- W4309231126 cites W3004279987 @default.
- W4309231126 cites W3006716981 @default.
- W4309231126 cites W3033910294 @default.
- W4309231126 cites W3045534008 @default.
- W4309231126 cites W3091134174 @default.
- W4309231126 cites W3093407181 @default.
- W4309231126 cites W3129401806 @default.
- W4309231126 cites W3132642897 @default.
- W4309231126 cites W3160480779 @default.
- W4309231126 cites W3196705307 @default.
- W4309231126 cites W4200149692 @default.
- W4309231126 cites W4207061315 @default.
- W4309231126 cites W4210376207 @default.
- W4309231126 cites W4210499727 @default.
- W4309231126 doi "https://doi.org/10.1101/2022.11.16.516732" @default.
- W4309231126 hasPublicationYear "2022" @default.
- W4309231126 type Work @default.
- W4309231126 citedByCount "0" @default.
- W4309231126 crossrefType "posted-content" @default.
- W4309231126 hasAuthorship W4309231126A5007869766 @default.
- W4309231126 hasAuthorship W4309231126A5008247363 @default.
- W4309231126 hasAuthorship W4309231126A5012921461 @default.
- W4309231126 hasAuthorship W4309231126A5020819058 @default.
- W4309231126 hasAuthorship W4309231126A5022686105 @default.
- W4309231126 hasAuthorship W4309231126A5028641049 @default.
- W4309231126 hasAuthorship W4309231126A5031383697 @default.
- W4309231126 hasAuthorship W4309231126A5038172787 @default.
- W4309231126 hasAuthorship W4309231126A5043214777 @default.
- W4309231126 hasAuthorship W4309231126A5049206710 @default.
- W4309231126 hasAuthorship W4309231126A5056530872 @default.
- W4309231126 hasAuthorship W4309231126A5066949471 @default.
- W4309231126 hasAuthorship W4309231126A5067179209 @default.
- W4309231126 hasAuthorship W4309231126A5068046399 @default.
- W4309231126 hasAuthorship W4309231126A5073908949 @default.
- W4309231126 hasBestOaLocation W43092311261 @default.
- W4309231126 hasConcept C104317684 @default.
- W4309231126 hasConcept C104397665 @default.
- W4309231126 hasConcept C150194340 @default.
- W4309231126 hasConcept C157585117 @default.
- W4309231126 hasConcept C162317418 @default.
- W4309231126 hasConcept C177212765 @default.
- W4309231126 hasConcept C41008148 @default.