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- W4309231433 abstract "This research paper studied the interplay of vascular endothelial growth factor receptor type 2 (VEGFR2), high dietary phosphate, and Klotho, an antiaging protein, in peritubular structure and kidney fibrosis. Klotho protein was shown to maintain VEGFR2 expression in the kidney and reduce high phosphate-induced cell injury. However, Klotho cytoprotection was attenuated by VEGFR2 inhibition. Thus, normal VEGFR2 function is required for vascular integrity and Klotho to exert vascular protective and antifibrotic actions in the kidney." @default.
- W4309231433 created "2022-11-24" @default.
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- W4309231433 date "2023-01-01" @default.
- W4309231433 modified "2023-09-27" @default.
- W4309231433 title "VEGFR2 insufficiency enhances phosphotoxicity and undermines Klotho’s protection against peritubular capillary rarefaction and kidney fibrosis" @default.
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- W4309231433 doi "https://doi.org/10.1152/ajprenal.00149.2022" @default.
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