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- W4309231699 abstract "The striatum links neuronal circuits in the human brain, and its malfunction causes neuronal disorders such as Huntington's disease (HD). A human striatum model that recapitulates fetal striatal development is vital to decoding the pathogenesis of striatum-related neurological disorders and developing therapeutic strategies. Here, we developed a method to construct human striatal organoids (hStrOs) from human pluripotent stem cells (hPSCs), including hStrOs-derived assembloids. Our hStrOs partially replicated the fetal striatum and formed striosome and matrix-like compartments in vitro. Single-cell RNA sequencing revealed distinct striatal lineages in hStrOs, diverging from dorsal forebrain fate. Using hStrOs-derived assembloids, we replicated the striatal targeting projections from different brain parts. Furthermore, hStrOs can serve as hosts for striatal neuronal allografts to test allograft neuronal survival and functional integration. Our hStrOs are suitable for studying striatal development and related disorders, characterizing the neural circuitry between different brain regions, and testing therapeutic strategies." @default.
- W4309231699 created "2022-11-24" @default.
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- W4309231699 date "2022-11-17" @default.
- W4309231699 modified "2023-10-07" @default.
- W4309231699 title "Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments" @default.
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- W4309231699 doi "https://doi.org/10.1371/journal.pbio.3001868" @default.
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