FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309231812> ?p ?o ?g. }

• W4309231812 endingPage "e1010713" @default.
• W4309231812 startingPage "e1010713" @default.
• W4309231812 abstract "The relationship between interactions, flexibility and disorder in proteins has been explored from many angles over the years: folding upon binding, flexibility of the core relative to the periphery, entropy changes, etc. In this work, we provide statistical evidence for the involvement of highly mobile and disordered regions in complex assembly. We ordered the entire set of X-ray crystallographic structures in the Protein Data Bank into hierarchies of progressive interactions involving identical or very similar protein chains, yielding 40205 hierarchies of protein complexes with increasing numbers of partners. We then examine them as proxies for the assembly pathways. Using this database, we show that upon oligomerisation, the new interfaces tend to be observed at residues that were characterised as softly disordered (flexible, amorphous or missing residues) in the complexes preceding them in the hierarchy. We also rule out the possibility that this correlation is just a surface effect by restricting the analysis to residues on the surface of the complexes. Interestingly, we find that the location of soft disordered residues in the sequence changes as the number of partners increases. Our results show that there is a general mechanism for protein assembly that involves soft disorder and modulates the way protein complexes are assembled. This work highlights the difficulty of predicting the structure of large protein complexes from sequence and emphasises the importance of linking predictors of soft disorder to the next generation of predictors of complex structure. Finally, we investigate the relationship between the Alphafold2's confidence metric pLDDT for structure prediction in unbound versus bound structures, and soft disorder. We show a strong correlation between Alphafold2 low confidence residues and the union of all regions of soft disorder observed in the hierarchy. This paves the way for using the pLDDT metric as a proxy for predicting interfaces and assembly paths." @default.
• W4309231812 created "2022-11-24" @default.
• W4309231812 creator A5011613939 @default.
• W4309231812 creator A5038174177 @default.
• W4309231812 date "2022-11-17" @default.
• W4309231812 modified "2023-10-08" @default.
• W4309231812 title "Soft disorder modulates the assembly path of protein complexes" @default.
• W4309231812 cites W1975121208 @default.
• W4309231812 cites W1984164188 @default.
• W4309231812 cites W1994840640 @default.
• W4309231812 cites W2004698009 @default.
• W4309231812 cites W2006192061 @default.
• W4309231812 cites W2014776147 @default.
• W4309231812 cites W2023333666 @default.
• W4309231812 cites W2062858001 @default.
• W4309231812 cites W2071046962 @default.
• W4309231812 cites W2096929343 @default.
• W4309231812 cites W2109685531 @default.
• W4309231812 cites W2114850508 @default.
• W4309231812 cites W2120744225 @default.
• W4309231812 cites W2128893409 @default.
• W4309231812 cites W2147610376 @default.
• W4309231812 cites W2162720882 @default.
• W4309231812 cites W2162980545 @default.
• W4309231812 cites W2168220711 @default.
• W4309231812 cites W2762070994 @default.
• W4309231812 cites W2800899372 @default.
• W4309231812 cites W2911872747 @default.
• W4309231812 cites W2950954328 @default.
• W4309231812 cites W2953008890 @default.
• W4309231812 cites W3120019274 @default.
• W4309231812 cites W3177828909 @default.
• W4309231812 cites W3183475563 @default.
• W4309231812 cites W3195375135 @default.
• W4309231812 cites W3212912034 @default.
• W4309231812 cites W4220824576 @default.
• W4309231812 cites W4225378695 @default.
• W4309231812 cites W4226162164 @default.
• W4309231812 cites W4281790889 @default.
• W4309231812 cites W4308463927 @default.
• W4309231812 cites W634123086 @default.
• W4309231812 doi "https://doi.org/10.1371/journal.pcbi.1010713" @default.
• W4309231812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36395332" @default.
• W4309231812 hasPublicationYear "2022" @default.
• W4309231812 type Work @default.
• W4309231812 citedByCount "3" @default.
• W4309231812 countsByYear W43092318122023 @default.
• W4309231812 crossrefType "journal-article" @default.
• W4309231812 hasAuthorship W4309231812A5011613939 @default.
• W4309231812 hasAuthorship W4309231812A5038174177 @default.
• W4309231812 hasBestOaLocation W43092318121 @default.
• W4309231812 hasConcept C105795698 @default.
• W4309231812 hasConcept C106301342 @default.
• W4309231812 hasConcept C119145174 @default.
• W4309231812 hasConcept C121332964 @default.
• W4309231812 hasConcept C121864883 @default.
• W4309231812 hasConcept C124589349 @default.
• W4309231812 hasConcept C178790620 @default.
• W4309231812 hasConcept C185592680 @default.
• W4309231812 hasConcept C186060115 @default.
• W4309231812 hasConcept C204328495 @default.
• W4309231812 hasConcept C2780598303 @default.
• W4309231812 hasConcept C32909587 @default.
• W4309231812 hasConcept C33923547 @default.
• W4309231812 hasConcept C41008148 @default.
• W4309231812 hasConcept C47701112 @default.
• W4309231812 hasConcept C55493867 @default.
• W4309231812 hasConcept C60644358 @default.
• W4309231812 hasConcept C62520636 @default.
• W4309231812 hasConcept C69308434 @default.
• W4309231812 hasConcept C70721500 @default.
• W4309231812 hasConcept C78458016 @default.
• W4309231812 hasConcept C8010536 @default.
• W4309231812 hasConcept C86803240 @default.
• W4309231812 hasConceptScore W4309231812C105795698 @default.
• W4309231812 hasConceptScore W4309231812C106301342 @default.
• W4309231812 hasConceptScore W4309231812C119145174 @default.
• W4309231812 hasConceptScore W4309231812C121332964 @default.
• W4309231812 hasConceptScore W4309231812C121864883 @default.
• W4309231812 hasConceptScore W4309231812C124589349 @default.
• W4309231812 hasConceptScore W4309231812C178790620 @default.
• W4309231812 hasConceptScore W4309231812C185592680 @default.
• W4309231812 hasConceptScore W4309231812C186060115 @default.
• W4309231812 hasConceptScore W4309231812C204328495 @default.
• W4309231812 hasConceptScore W4309231812C2780598303 @default.
• W4309231812 hasConceptScore W4309231812C32909587 @default.
• W4309231812 hasConceptScore W4309231812C33923547 @default.
• W4309231812 hasConceptScore W4309231812C41008148 @default.
• W4309231812 hasConceptScore W4309231812C47701112 @default.
• W4309231812 hasConceptScore W4309231812C55493867 @default.
• W4309231812 hasConceptScore W4309231812C60644358 @default.
• W4309231812 hasConceptScore W4309231812C62520636 @default.
• W4309231812 hasConceptScore W4309231812C69308434 @default.
• W4309231812 hasConceptScore W4309231812C70721500 @default.
• W4309231812 hasConceptScore W4309231812C78458016 @default.
• W4309231812 hasConceptScore W4309231812C8010536 @default.
• W4309231812 hasConceptScore W4309231812C86803240 @default.
• W4309231812 hasFunder F4320310209 @default.

• next