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- W4309233078 endingPage "785" @default.
- W4309233078 startingPage "779" @default.
- W4309233078 abstract "Carbon-hydrogen (C-H) functionalization of pyridines is a powerful tool for the rapid construction and derivatization of many agrochemicals, pharmaceuticals, and materials. Because of the inherent electronic properties of pyridines, selective meta-C-H functionalization is challenging. Here, we present a protocol for highly regioselective meta-C-H trifluoromethylation, perfluoroalkylation, chlorination, bromination, iodination, nitration, sulfanylation, and selenylation of pyridines through a redox-neutral dearomatization-rearomatization process. The introduced dearomative activation mode provides a diversification platform for meta-selective reactions on pyridines and other azaarenes through radical as well as ionic pathways. The broad scope and high selectivity of these catalyst-free reactions render these processes applicable for late-stage functionalization of drugs." @default.
- W4309233078 created "2022-11-24" @default.
- W4309233078 creator A5023064644 @default.
- W4309233078 creator A5088614429 @default.
- W4309233078 creator A5090922097 @default.
- W4309233078 date "2022-11-18" @default.
- W4309233078 modified "2023-10-16" @default.
- W4309233078 title "Radical and ionic <i>meta</i> -C–H functionalization of pyridines, quinolines, and isoquinolines" @default.
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- W4309233078 doi "https://doi.org/10.1126/science.ade6029" @default.
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