Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309234906> ?p ?o ?g. }
- W4309234906 endingPage "15558" @default.
- W4309234906 startingPage "15540" @default.
- W4309234906 abstract "Clinically acquired resistance is a major challenge in cancer therapies with small-molecule kinase inhibitors (SMKIs). Gatekeeper mutations in the ATP-binding pocket of kinases are the most common mutations leading to acquired resistance. To date, seven new-generation kinase inhibitors targeting gatekeeper mutations have been approved by the FDA; however, the clinical need is still unmet. Here, we systematically summarize the types of gatekeeper mutations across the kinase family, the structural basis for acquired resistance, and newly developed SMKIs targeting gatekeeper mutations as well as highlight the opportunities and challenges of kinase drug discovery for targeting gatekeeper mutations." @default.
- W4309234906 created "2022-11-24" @default.
- W4309234906 creator A5015139258 @default.
- W4309234906 creator A5039784114 @default.
- W4309234906 creator A5045350828 @default.
- W4309234906 creator A5067839548 @default.
- W4309234906 date "2022-11-17" @default.
- W4309234906 modified "2023-10-17" @default.
- W4309234906 title "Targeting Gatekeeper Mutations for Kinase Drug Discovery" @default.
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