Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309235570> ?p ?o ?g. }
- W4309235570 abstract "Cryptochromes (CRYs) are evolutionarily conserved photolyase-like photoreceptors found in almost all species, including mammals. CRYs regulate transcription by modulating the activity of several transcription factors, but whether and how they affect pre-mRNA processing are unknown. Photoperiod and temperature are closely associated seasonal cues that influence reproductive timing in plants. CRYs mediate photoperiod-responsive floral initiation, but it is largely unknown whether and how they are also involved in thermosensory flowering. We establish here that blue light and CRY2 play critical roles in thermosensory flowering in Arabidopsis thaliana by regulating RNA alternative splicing (AS) to affect protein expression and development. CRY2 INTERACTING SPLICING FACTOR 1 (CIS1) interacts with CRY2 in a blue light-dependent manner and promotes CRY2-mediated thermosensory flowering. Blue light, CRYs, and CISs affect transcriptome-wide AS profiles, including those of FLOWERING LOCUS M (FLM), which is critical for temperature modulation of flowering. Moreover, CIS1 binds to the FLM pre-mRNA to regulate its AS, while CRY2 regulates the RNA-binding activity of CIS1. Thus, blue light regulates thermosensory flowering via a CRY2-CIS1-FLM signaling pathway that links flowering responses to both light and ambient temperature." @default.
- W4309235570 created "2022-11-25" @default.
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- W4309235570 date "2022-11-17" @default.
- W4309235570 modified "2023-10-17" @default.
- W4309235570 title "CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing" @default.
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- W4309235570 doi "https://doi.org/10.1038/s41467-022-34886-2" @default.
- W4309235570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36396657" @default.
- W4309235570 hasPublicationYear "2022" @default.
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