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- W4309243146 abstract "Respiratory complex I is a ~1-MDa proton pump in mitochondria. Its structure has been revealed in great detail, but the structural basis of its assembly, in humans involving at least 15 assembly factors, is essentially unknown. We determined cryo–electron microscopy structures of assembly intermediates associated with assembly factor NDUFAF1 in a yeast model system. Subunits ND2 and NDUFC2 together with assembly factors NDUFAF1 and CIA84 form the nucleation point of the NDUFAF1-dependent assembly pathway. Unexpectedly, the cardiolipin remodeling enzyme tafazzin is an integral component of this core complex. In a later intermediate, all 12 subunits of the proximal proton pump module have assembled. NDUFAF1 locks the central ND3 subunit in an assembly-competent conformation, and major rearrangements of central subunits are required for complex I maturation." @default.
- W4309243146 created "2022-11-25" @default.
- W4309243146 creator A5000745618 @default.
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- W4309243146 date "2022-11-18" @default.
- W4309243146 modified "2023-10-16" @default.
- W4309243146 title "Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling" @default.
- W4309243146 cites W1490805894 @default.
- W4309243146 cites W1568406795 @default.
- W4309243146 cites W1963983672 @default.
- W4309243146 cites W1965531591 @default.
- W4309243146 cites W1965586048 @default.
- W4309243146 cites W1971439989 @default.
- W4309243146 cites W1971957605 @default.
- W4309243146 cites W1996791543 @default.
- W4309243146 cites W1997450316 @default.
- W4309243146 cites W2001425543 @default.
- W4309243146 cites W2009620479 @default.
- W4309243146 cites W2009970917 @default.
- W4309243146 cites W2015476639 @default.
- W4309243146 cites W2017550994 @default.
- W4309243146 cites W2020719323 @default.
- W4309243146 cites W2023229609 @default.
- W4309243146 cites W2023416304 @default.
- W4309243146 cites W2030408645 @default.
- W4309243146 cites W2031079887 @default.
- W4309243146 cites W2041982853 @default.
- W4309243146 cites W2042183674 @default.
- W4309243146 cites W2043621161 @default.
- W4309243146 cites W2066429772 @default.
- W4309243146 cites W2077637487 @default.
- W4309243146 cites W2090192950 @default.
- W4309243146 cites W2110597353 @default.
- W4309243146 cites W2117140251 @default.
- W4309243146 cites W2120772351 @default.
- W4309243146 cites W2124026197 @default.
- W4309243146 cites W2125977147 @default.
- W4309243146 cites W2135517170 @default.
- W4309243146 cites W2135638621 @default.
- W4309243146 cites W2142678478 @default.
- W4309243146 cites W2145863585 @default.
- W4309243146 cites W2152562710 @default.
- W4309243146 cites W2161905497 @default.
- W4309243146 cites W2168600251 @default.
- W4309243146 cites W2194759443 @default.
- W4309243146 cites W2333034303 @default.
- W4309243146 cites W2341118641 @default.
- W4309243146 cites W2509037889 @default.
- W4309243146 cites W2520656712 @default.
- W4309243146 cites W2528211287 @default.
- W4309243146 cites W2587625522 @default.
- W4309243146 cites W2593511418 @default.
- W4309243146 cites W2734356283 @default.
- W4309243146 cites W2735911553 @default.
- W4309243146 cites W2742348312 @default.
- W4309243146 cites W2745371978 @default.
- W4309243146 cites W2745530328 @default.
- W4309243146 cites W2774178591 @default.
- W4309243146 cites W2786390877 @default.
- W4309243146 cites W2806917274 @default.
- W4309243146 cites W2888999957 @default.
- W4309243146 cites W2897349546 @default.
- W4309243146 cites W2897708283 @default.
- W4309243146 cites W2899760200 @default.
- W4309243146 cites W2916585268 @default.
- W4309243146 cites W2924310031 @default.
- W4309243146 cites W2938574745 @default.
- W4309243146 cites W2946573657 @default.
- W4309243146 cites W2950108090 @default.
- W4309243146 cites W2952729952 @default.
- W4309243146 cites W2953320394 @default.
- W4309243146 cites W2989684750 @default.
- W4309243146 cites W2993771658 @default.
- W4309243146 cites W2995505240 @default.
- W4309243146 cites W3000012887 @default.
- W4309243146 cites W3006585493 @default.
- W4309243146 cites W3013930123 @default.
- W4309243146 cites W3017377684 @default.
- W4309243146 cites W3049001491 @default.
- W4309243146 cites W3092932912 @default.
- W4309243146 cites W3095583226 @default.
- W4309243146 cites W3095597907 @default.
- W4309243146 cites W3113092848 @default.
- W4309243146 cites W3177828909 @default.
- W4309243146 cites W3186193846 @default.
- W4309243146 cites W3204309866 @default.
- W4309243146 cites W3204699892 @default.
- W4309243146 cites W3208478928 @default.
- W4309243146 cites W3211597279 @default.
- W4309243146 cites W3213779066 @default.
- W4309243146 cites W4206033728 @default.
- W4309243146 doi "https://doi.org/10.1126/sciadv.add3855" @default.
- W4309243146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36383672" @default.
- W4309243146 hasPublicationYear "2022" @default.
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