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• W4309243563 abstract "The present study is aimed at reviewing and meta-analyzing the currently published data on the diagnostic accuracy of Ortho VITROS SARS-CoV-2 antigen test for diagnosing acute SARS-CoV-2 infections.An electronic search was conducted in Scopus and Medline with the keywords VITROS AND antigen AND COVID-19 OR SARS-CoV-2 AND immunoassay within the search fields TITLE AND ABSTRACT AND KEYWORDS, without no date (i.e., up to January 23, 2022) or language restrictions, aimed at detecting documents reporting the diagnostic accuracy of this SARSCoV-2 immunoassay compared with reference molecular diagnostic methods.Overall, 5 studies (n=2734 samples) were finally included in our pooled analysis, four of which also provided diagnostic sensitivity in oro-and nasopharyngeal samples with high viral load. The pooled cumulative diagnostic sensitivity and specificity were 0.82 (95%CI, 0.78-0.86) and 1.00 (95%CI, 1.00-1.00), respectively, whilst the area under the curve was 0.995 (95%CI, 0.993-0.997), the cumulative agreement 97.2% (95%CI, 96.5-97.8%), with 0.89 (95%CI, 0.86-0.91) kappa statistics, thus reflecting an almost perfect concordance with reference molecular biology techniques. The pooled diagnostic sensitivity in samples with high viral load was as high as 0.98 (95%CI, 0.96-0.99).These results confirm that the automated and high-throughput Ortho VITROS SARS-CoV-2 antigen test may represent a valuable surrogate of molecular testing for diagnosing acute SARS-CoV-2 infections, especially in subjects with high viral load.Ova studija ima za cilj pregled i meta-analizu trenutno objavljenih podataka o dijagnostičkoj tačnosti Ortho VITROS SARS-CoV-2 antigen testa za dijagnostikovanje akutnih SARS-CoV-2 infekcija.Sprovedena je elektronska pretraga u Scopusu i Medline-u sa ključnim rečima VITROS i antigen i COVID-19 ili SARS-CoV-2 i imunoassay u okviru polja za pretragu NASLOV i ABSTRACT i KLJUČNE REČI, bez datuma (tj. do 23. januara 2022.) ili jezičkih ograničenja, sa ciljem da se otkriju dokumenti koji izveštavaju o dijagnostičkoj tajnosti ovog imuno eseja SARS-CoV-2 u poređenju sa referentnim molekularnim dijagnostičkim metodama.Ukupno, 5 studija (n=2734 uzorka) je konačno uključeno u našu objedinjenu analizu, od kojih su četiri takođe pružile dijagnostiku osetljivost u oroi nazofaringealnim uzorcima sa visokim virusnim opterećenjem. Objedinjena kumulativna dijagnostika osetljivost i specifičnost bile su 0,82 (95%CI, 0,78-0,86) i 1,00 (95%CI, 1,00-1,00), respektivno, dok je površina ispod krive bila 0,995 (95%CI, 0,9973-0). kumulativno slaganje 97,2% (95%CI, 96,5-97,8%), sa 0,89 (95%CI, 0,86-0,91) kapa statistike, što odražava skoro savršenu saglasnost sa referentnim tehnikama molekularne biologije. Objedinjena dijagnostička osetljivost u uzorcima sa visokim virusnim opterećenjem bila je čak 0,98 (95% CI, 0,96-0,99).Ovi rezultati potvrđuju da automatizovani i visoko propusni Ortho VITROS SARS-CoV-2 antigen test može predstavljati vredan surogat molekularnog testiranja za dijagnostikovanje akutnih SARS-CoV-2 infekcija, posebno kod subjekata sa visokim virusnim opterećenjem." @default.
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• W4309243563 date "2022-01-01" @default.
• W4309243563 modified "2023-10-17" @default.
• W4309243563 title "Critical literature review and pooled analysis of diagnostic accuracy of Ortho VITROS SARS-CoV-2 antigen test for diagnosing acute SARS-CoV-2 infections" @default.
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• W4309243563 doi "https://doi.org/10.5937/jomb0-36107" @default.
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