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- W4309244518 abstract "Autoimmune diseases are caused by a dysfunction of the acquired immune system. In a subset of autoimmune diseases, B cells escaping immune tolerance present autoantigen and produce cytokines and/or autoantibodies, resulting in systemic or organ-specific autoimmunity. Therefore, B cell depletion with monoclonal Abs targeting B cell lineage markers is standard care therapy for several B cell-mediated autoimmune disorders. In the last 5 years, genetically-engineered cellular immunotherapies targeting B cells have shown superior efficacy and long-term remission of B cell malignancies compared to historical clinical outcomes using B cell depletion with monoclonal Ab therapies. This has raised interest in understanding whether similar durable remission could be achieved with use of genetically-engineered cell therapies for autoimmunity. This review will focus on current human clinical trials using engineered cell therapies for B cell-associated autoimmune diseases." @default.
- W4309244518 created "2022-11-25" @default.
- W4309244518 creator A5003409611 @default.
- W4309244518 creator A5017017315 @default.
- W4309244518 date "2022-01-01" @default.
- W4309244518 modified "2023-09-30" @default.
- W4309244518 title "Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept" @default.
- W4309244518 cites W1967599448 @default.
- W4309244518 cites W1977810547 @default.
- W4309244518 cites W1978201901 @default.
- W4309244518 cites W1982865105 @default.
- W4309244518 cites W1992355845 @default.
- W4309244518 cites W1993290536 @default.
- W4309244518 cites W2001313261 @default.
- W4309244518 cites W2004019108 @default.
- W4309244518 cites W2006456576 @default.
- W4309244518 cites W2027638367 @default.
- W4309244518 cites W2028514870 @default.
- W4309244518 cites W2031941175 @default.
- W4309244518 cites W2040728132 @default.
- W4309244518 cites W2063340779 @default.
- W4309244518 cites W2075442135 @default.
- W4309244518 cites W2085412199 @default.
- W4309244518 cites W2091982948 @default.
- W4309244518 cites W2094800200 @default.
- W4309244518 cites W2095975942 @default.
- W4309244518 cites W2115953810 @default.
- W4309244518 cites W2123584409 @default.
- W4309244518 cites W2134451223 @default.
- W4309244518 cites W2135985608 @default.
- W4309244518 cites W2137467984 @default.
- W4309244518 cites W2141650788 @default.
- W4309244518 cites W2142262949 @default.
- W4309244518 cites W2142659101 @default.
- W4309244518 cites W2143000096 @default.
- W4309244518 cites W2147528615 @default.
- W4309244518 cites W2157877643 @default.
- W4309244518 cites W2159430424 @default.
- W4309244518 cites W2196709345 @default.
- W4309244518 cites W2342165557 @default.
- W4309244518 cites W2360020331 @default.
- W4309244518 cites W2469817155 @default.
- W4309244518 cites W2473078810 @default.
- W4309244518 cites W2531669554 @default.
- W4309244518 cites W2592697450 @default.
- W4309244518 cites W2602517913 @default.
- W4309244518 cites W2605350170 @default.
- W4309244518 cites W2617763104 @default.
- W4309244518 cites W2734398306 @default.
- W4309244518 cites W2750731598 @default.
- W4309244518 cites W2760653955 @default.
- W4309244518 cites W2782290297 @default.
- W4309244518 cites W2800529889 @default.
- W4309244518 cites W2883434080 @default.
- W4309244518 cites W2888063816 @default.
- W4309244518 cites W2891067691 @default.
- W4309244518 cites W2914301168 @default.
- W4309244518 cites W2918633605 @default.
- W4309244518 cites W2944608504 @default.
- W4309244518 cites W2972221943 @default.
- W4309244518 cites W3000276814 @default.
- W4309244518 cites W3006397964 @default.
- W4309244518 cites W3012054652 @default.
- W4309244518 cites W3022437762 @default.
- W4309244518 cites W3030080235 @default.
- W4309244518 cites W3046025665 @default.
- W4309244518 cites W3047276972 @default.
- W4309244518 cites W3081379129 @default.
- W4309244518 cites W3106589156 @default.
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- W4309244518 cites W3165411983 @default.
- W4309244518 cites W3174233267 @default.
- W4309244518 cites W3184375282 @default.
- W4309244518 cites W3185250096 @default.
- W4309244518 cites W3190820492 @default.
- W4309244518 cites W3197124040 @default.
- W4309244518 cites W3198073213 @default.
- W4309244518 cites W325958225 @default.
- W4309244518 cites W4210972925 @default.
- W4309244518 cites W4211188347 @default.
- W4309244518 cites W4220874827 @default.
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- W4309244518 doi "https://doi.org/10.4110/in.2022.22.e37" @default.
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