FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309246311> ?p ?o ?g. }

• W4309246311 endingPage "6522" @default.
• W4309246311 startingPage "6511" @default.
• W4309246311 abstract "Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) generally confers poor prognosis, however, patient outcomes are heterogeneous. The impact of TP53 allelic state and variant allele frequency (VAF) in AML-MRC remains poorly defined.We retrospectively evaluated 266 AML-MRC patients who had NGS testing at our institution from 2014 to 2020 and analyzed their clinical outcomes based on clinicopathological features.TP53 mutations were associated with cytogenetic abnormalities in 5q, 7q, 17p, and complex karyotype. Prognostic evaluation of TP53MUT AML-MRC revealed no difference in outcome between TP53 double/multi-hit state and single-hit state. Patients with high TP53MUT variant allele frequency (VAF) had inferior outcomes compared to patients with low TP53MUT VAF. When compared to TP53WT patients, TP53MUT patients had inferior outcomes regardless of MRC-defining criteria, TP53 allelic state, or VAF. TP53 mutations and elevated serum LDH were independent predictors for inferior OS and EFS, while PHF6 mutations and transplantation were independent predictors for favorable OS and EFS. NRAS mutation was an independent predictor for favorable EFS.Our study suggests that TP53MUT AML-MRC defines a very-high-risk subentity of AML in which novel therapies should be explored." @default.
• W4309246311 created "2022-11-25" @default.
• W4309246311 creator A5002489867 @default.
• W4309246311 creator A5011926043 @default.
• W4309246311 creator A5015532377 @default.
• W4309246311 creator A5018664175 @default.
• W4309246311 creator A5021467163 @default.
• W4309246311 creator A5026397928 @default.
• W4309246311 creator A5057436862 @default.
• W4309246311 creator A5057593975 @default.
• W4309246311 date "2022-11-16" @default.
• W4309246311 modified "2023-10-12" @default.
• W4309246311 title "Molecular characterization of <scp>AML‐MRC</scp> reveals <scp><i>TP53</i></scp> mutation as an adverse prognostic factor irrespective of <scp>MRC</scp>‐defining criteria, <scp><i>TP53</i></scp> allelic state, or <scp><i>TP53</i></scp> variant allele frequency" @default.
• W4309246311 cites W1255676896 @default.
• W4309246311 cites W1986993506 @default.
• W4309246311 cites W2041356430 @default.
• W4309246311 cites W2056960087 @default.
• W4309246311 cites W2076999892 @default.
• W4309246311 cites W2077290269 @default.
• W4309246311 cites W2107027906 @default.
• W4309246311 cites W2115707319 @default.
• W4309246311 cites W2142765738 @default.
• W4309246311 cites W2171383975 @default.
• W4309246311 cites W2419140434 @default.
• W4309246311 cites W2499799649 @default.
• W4309246311 cites W2559537906 @default.
• W4309246311 cites W2561258856 @default.
• W4309246311 cites W2576017084 @default.
• W4309246311 cites W2593474440 @default.
• W4309246311 cites W2768768130 @default.
• W4309246311 cites W2794480810 @default.
• W4309246311 cites W2799371335 @default.
• W4309246311 cites W2802748326 @default.
• W4309246311 cites W2804029080 @default.
• W4309246311 cites W2883399820 @default.
• W4309246311 cites W2892949113 @default.
• W4309246311 cites W2897503030 @default.
• W4309246311 cites W2908744276 @default.
• W4309246311 cites W2912804762 @default.
• W4309246311 cites W2915005663 @default.
• W4309246311 cites W2967772845 @default.
• W4309246311 cites W2984346248 @default.
• W4309246311 cites W2985197312 @default.
• W4309246311 cites W3000515035 @default.
• W4309246311 cites W3005047572 @default.
• W4309246311 cites W3005329625 @default.
• W4309246311 cites W3007376421 @default.
• W4309246311 cites W3015889007 @default.
• W4309246311 cites W3042954004 @default.
• W4309246311 cites W3043868243 @default.
• W4309246311 cites W3046671820 @default.
• W4309246311 cites W3048622934 @default.
• W4309246311 cites W3082631973 @default.
• W4309246311 cites W3088936653 @default.
• W4309246311 cites W3101740872 @default.
• W4309246311 cites W3102785656 @default.
• W4309246311 cites W3119649652 @default.
• W4309246311 cites W3120624848 @default.
• W4309246311 cites W3127422324 @default.
• W4309246311 cites W3131928636 @default.
• W4309246311 cites W3134127715 @default.
• W4309246311 cites W3176370909 @default.
• W4309246311 cites W3177711368 @default.
• W4309246311 cites W3185929814 @default.
• W4309246311 cites W3197195116 @default.
• W4309246311 cites W3212447982 @default.
• W4309246311 cites W4200195529 @default.
• W4309246311 cites W4210694051 @default.
• W4309246311 cites W4210791570 @default.
• W4309246311 cites W4283271244 @default.
• W4309246311 cites W4283716970 @default.
• W4309246311 doi "https://doi.org/10.1002/cam4.5421" @default.
• W4309246311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36394085" @default.
• W4309246311 hasPublicationYear "2022" @default.
• W4309246311 type Work @default.
• W4309246311 citedByCount "3" @default.
• W4309246311 countsByYear W43092463112023 @default.
• W4309246311 crossrefType "journal-article" @default.
• W4309246311 hasAuthorship W4309246311A5002489867 @default.
• W4309246311 hasAuthorship W4309246311A5011926043 @default.
• W4309246311 hasAuthorship W4309246311A5015532377 @default.
• W4309246311 hasAuthorship W4309246311A5018664175 @default.
• W4309246311 hasAuthorship W4309246311A5021467163 @default.
• W4309246311 hasAuthorship W4309246311A5026397928 @default.
• W4309246311 hasAuthorship W4309246311A5057436862 @default.
• W4309246311 hasAuthorship W4309246311A5057593975 @default.
• W4309246311 hasBestOaLocation W43092463111 @default.
• W4309246311 hasConcept C104317684 @default.
• W4309246311 hasConcept C121608353 @default.
• W4309246311 hasConcept C126322002 @default.
• W4309246311 hasConcept C143998085 @default.
• W4309246311 hasConcept C180754005 @default.
• W4309246311 hasConcept C21790070 @default.
• W4309246311 hasConcept C2778729363 @default.
• W4309246311 hasConcept C2781187634 @default.
• W4309246311 hasConcept C501734568 @default.
• W4309246311 hasConcept C502942594 @default.
• W4309246311 hasConcept C526805850 @default.

• next