FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309258296> ?p ?o ?g. }

• W4309258296 abstract "Prostate-specific membrane antigen (PSMA) is a promising molecular target for prostate cancer (PCa) that has allowed the development of a novel diagnostic approach to PCA in the primary and recurrent settings.To summarize available data and recommendations regarding the use of PSMA in newly diagnosed and recurrent PCa via a narrative review.A literature review was conducted using MEDLINE (via PubMed) and Scopus. The search strategy included meta-analyses, reviews, and original studies on staging and restaging with 68Ga-PSMA positron emission tomography (PET)/computed tomography (CT).Studies comparing PSMA-targeted imaging and conventional imaging suggest superior performance of PSMA-targeted imaging in primary and recurrent PCa, albeit with several clinically relevant limitations. Pretreatment 68Ga-PSMA PET/CT allowed more accurate PCa staging in compared to routine practice for high-risk cases, and identified a number of otherwise unknown metastatic lesions. In biochemically recurrent PCa, PSMA PET can reveal sites of recurrence with greater sensitivity and specificity than conventional imaging, potentially detecting a major proportion of occult disease. This review will help providers in applying the most up-to-date and relevant literature to (1) determine which patients truly have oligometastatic disease and (2) ascertain who is most likely to experience a meaningful response to local consolidation in the biochemical recurrence setting.Data on PSMA diagnostic studies in primary and recurrent PCa highlight the accuracy and clinical application of PSMA PET. While this review and the evidence to date might lead to a perception of superiority in metastasis directed therapy, fundamental lack of phase III clinical trials with clinically meaningful outcomes are yet to be determined.PSMA (prostate-specific membrane antigen) scans have shown great promise for initial evaluation of prostate cancer (PCa) and in detection of PCa recurrence. The benefits are more apparent for initial staging of PCa. There are more limited clinical trial results for PCa recurrence on how best to use this new technique to guide cancer treatment." @default.
• W4309258296 created "2022-11-25" @default.
• W4309258296 creator A5008460713 @default.
• W4309258296 creator A5015363712 @default.
• W4309258296 creator A5017784739 @default.
• W4309258296 creator A5044519122 @default.
• W4309258296 creator A5060238737 @default.
• W4309258296 creator A5063276705 @default.
• W4309258296 creator A5077911967 @default.
• W4309258296 creator A5083566572 @default.
• W4309258296 date "2022-11-01" @default.
• W4309258296 modified "2023-10-17" @default.
• W4309258296 title "Incorporating Prostate-specific Membrane Antigen Positron Emission Tomography in Management Decisions for Men with Newly Diagnosed or Biochemically Recurrent Prostate Cancer" @default.
• W4309258296 cites W136361063 @default.
• W4309258296 cites W1490266165 @default.
• W4309258296 cites W1995589176 @default.
• W4309258296 cites W2049670016 @default.
• W4309258296 cites W2051133253 @default.
• W4309258296 cites W2069380387 @default.
• W4309258296 cites W2091083791 @default.
• W4309258296 cites W2103623995 @default.
• W4309258296 cites W2109199549 @default.
• W4309258296 cites W2117441254 @default.
• W4309258296 cites W2123985787 @default.
• W4309258296 cites W2124586180 @default.
• W4309258296 cites W2129152887 @default.
• W4309258296 cites W2139882239 @default.
• W4309258296 cites W2147136637 @default.
• W4309258296 cites W2155421560 @default.
• W4309258296 cites W2230026600 @default.
• W4309258296 cites W2287868019 @default.
• W4309258296 cites W2326657743 @default.
• W4309258296 cites W2406375637 @default.
• W4309258296 cites W2414412661 @default.
• W4309258296 cites W2511755939 @default.
• W4309258296 cites W2523975348 @default.
• W4309258296 cites W2525349940 @default.
• W4309258296 cites W2546110733 @default.
• W4309258296 cites W2560438049 @default.
• W4309258296 cites W2585109238 @default.
• W4309258296 cites W2589983641 @default.
• W4309258296 cites W2594750672 @default.
• W4309258296 cites W2626115496 @default.
• W4309258296 cites W2737584987 @default.
• W4309258296 cites W2766240872 @default.
• W4309258296 cites W2769738907 @default.
• W4309258296 cites W2770717184 @default.
• W4309258296 cites W2784001077 @default.
• W4309258296 cites W2786780259 @default.
• W4309258296 cites W2797095289 @default.
• W4309258296 cites W2801398567 @default.
• W4309258296 cites W2807646053 @default.
• W4309258296 cites W2809719608 @default.
• W4309258296 cites W2811260982 @default.
• W4309258296 cites W2884198111 @default.
• W4309258296 cites W2886394563 @default.
• W4309258296 cites W2886626452 @default.
• W4309258296 cites W2887423209 @default.
• W4309258296 cites W2903357641 @default.
• W4309258296 cites W2904968124 @default.
• W4309258296 cites W2911114425 @default.
• W4309258296 cites W2911522675 @default.
• W4309258296 cites W2924617625 @default.
• W4309258296 cites W2926733161 @default.
• W4309258296 cites W2954448304 @default.
• W4309258296 cites W2966792020 @default.
• W4309258296 cites W2971771201 @default.
• W4309258296 cites W2976812582 @default.
• W4309258296 cites W2984560413 @default.
• W4309258296 cites W2989413482 @default.
• W4309258296 cites W2990480584 @default.
• W4309258296 cites W2990822673 @default.
• W4309258296 cites W2999188467 @default.
• W4309258296 cites W2999871298 @default.
• W4309258296 cites W3004841319 @default.
• W4309258296 cites W3006570625 @default.
• W4309258296 cites W3009016370 @default.
• W4309258296 cites W3012827461 @default.
• W4309258296 cites W3013251573 @default.
• W4309258296 cites W3015639670 @default.
• W4309258296 cites W3026360852 @default.
• W4309258296 cites W3032651552 @default.
• W4309258296 cites W3047110054 @default.
• W4309258296 cites W3048516240 @default.
• W4309258296 cites W3048613081 @default.
• W4309258296 cites W3086743023 @default.
• W4309258296 cites W3089621961 @default.
• W4309258296 cites W3102689474 @default.
• W4309258296 cites W3107679572 @default.
• W4309258296 cites W3110276552 @default.
• W4309258296 cites W3110862590 @default.
• W4309258296 cites W3116858703 @default.
• W4309258296 cites W3122250961 @default.
• W4309258296 cites W3125743225 @default.
• W4309258296 cites W3127573510 @default.
• W4309258296 cites W3128646645 @default.
• W4309258296 cites W3129102215 @default.
• W4309258296 cites W3129520566 @default.
• W4309258296 cites W3132398728 @default.
• W4309258296 cites W3133949928 @default.

• next