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- W4309261908 abstract "Abstract Background Nocturia is a manifestation of systemic disease, of which chronic kidney disease is an independent predictor of nocturia because of its osmotic diuretic mechanism. However, to our knowledge, previous studies have not examined the relationship between nocturia and eGFR. Objective The purpose of this study was to assess the association between nocturia exposure and eGFR in the general US population. Methods Our study was a cross-sectional examination of 12,265 regular Americans who took part in the rvey NHANES between 2005 and 2018. After controlling for gender, age, race, fasting blood glucose, glycosylated hemoglobin, ALT, AST, TG, CHOL, HDL, LDL, BMI, diabetes, hypertension, alcohol consumption, tobacco use and PHQ9 score, a multiple regression analysis was performed to determine the association between nocturia and eGFR. Covariate-specific hierarchical analysis and interaction testing were performed. A sensitivity analysis was then conducted between the CKD group, the non-CKD group, and the various CKD prognostic risk groups. Results Multiple regression analysis showed that the frequency of nocturia increased by 1 time, and eGFR decreased 2.0 mL/min/1.73m 2 (95%CI: -2.4, -1.7). Compared with no nocturia, the decrease of eGFR was the most significant 4 times per night (95%CI: -10.7, -5.4). Our results remained stable in the CKD and non-CKD groups. Within all CKD prognostic risk groups, only the moderately increased risk and low-risk groups had comparable results. Conclusions Increased frequency of nocturia was associated with a decrease in eGFR, regardless of the diagnosis of CKD. However, no correlation between nocturia and eGFR was observed in very high risk and high risk groups." @default.
- W4309261908 created "2022-11-25" @default.
- W4309261908 creator A5034352772 @default.
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- W4309261908 creator A5078230334 @default.
- W4309261908 date "2022-11-17" @default.
- W4309261908 modified "2023-09-27" @default.
- W4309261908 title "Association of nocturia with estimated glomerular filtration rate: a cross-sectional study from the NHANES 2005-2018" @default.
- W4309261908 doi "https://doi.org/10.21203/rs.3.rs-2259774/v1" @default.
- W4309261908 hasPublicationYear "2022" @default.
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