Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309263603> ?p ?o ?g. }
- W4309263603 abstract "SUMMARY Eukaryotic cells tightly control their size, but the relevant aspect of size is unknown in most cases. Fission yeast divide at a threshold cell surface area due in part to the protein kinase Cdr2. We find that fission yeast cells only divide by surface area under a size threshold but shift to volume-based divisions when they reach a larger size. The size threshold for changing from surface area to volume-based control is set by ploidy. Within this size control system, we identified the mitotic activator Cdc25 as a volume-based sizer molecule, while the mitotic cyclin Cdc13 accumulates as a timer. We propose an integrated model for cell size control based on multiple signaling pathways that report on distinct aspects of cell size and growth, including cell surface area (Cdr2), cell volume (Cdc25), and time (Cdc13). Combined modeling and experiments show how this system can generate both sizer and adder-like properties. HIGHLIGHTS Fission yeast use surface area or volume-based cell size control depending on overall size and ploidy Mitotic activator Cdc25 exhibits properties of a volume-based sizer molecule Mitotic cyclin Cdc13 accumulates in the nucleus dependent on time, not size Combined modeling and experiments identify conditions for sizer versus adder behavior" @default.
- W4309263603 created "2022-11-25" @default.
- W4309263603 creator A5010917720 @default.
- W4309263603 creator A5022267407 @default.
- W4309263603 creator A5053718440 @default.
- W4309263603 creator A5075839935 @default.
- W4309263603 date "2022-11-17" @default.
- W4309263603 modified "2023-10-14" @default.
- W4309263603 title "The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time" @default.
- W4309263603 cites W1507864482 @default.
- W4309263603 cites W1520947267 @default.
- W4309263603 cites W1829149466 @default.
- W4309263603 cites W1894928878 @default.
- W4309263603 cites W1907376883 @default.
- W4309263603 cites W1911951809 @default.
- W4309263603 cites W1966062610 @default.
- W4309263603 cites W1971908328 @default.
- W4309263603 cites W1979341555 @default.
- W4309263603 cites W1981413140 @default.
- W4309263603 cites W1984653721 @default.
- W4309263603 cites W1986622285 @default.
- W4309263603 cites W1987144436 @default.
- W4309263603 cites W1990265320 @default.
- W4309263603 cites W1990819034 @default.
- W4309263603 cites W2009389356 @default.
- W4309263603 cites W2014965747 @default.
- W4309263603 cites W2034632104 @default.
- W4309263603 cites W2035091349 @default.
- W4309263603 cites W2038340312 @default.
- W4309263603 cites W2040091286 @default.
- W4309263603 cites W2047524281 @default.
- W4309263603 cites W2048875557 @default.
- W4309263603 cites W2059155490 @default.
- W4309263603 cites W2066883617 @default.
- W4309263603 cites W2073285068 @default.
- W4309263603 cites W2081298797 @default.
- W4309263603 cites W2091060631 @default.
- W4309263603 cites W2097005988 @default.
- W4309263603 cites W2098145231 @default.
- W4309263603 cites W2109262751 @default.
- W4309263603 cites W2122461345 @default.
- W4309263603 cites W2123999282 @default.
- W4309263603 cites W2125155670 @default.
- W4309263603 cites W2139752884 @default.
- W4309263603 cites W2172213445 @default.
- W4309263603 cites W2188979715 @default.
- W4309263603 cites W2194184864 @default.
- W4309263603 cites W2194986544 @default.
- W4309263603 cites W2285630760 @default.
- W4309263603 cites W2414953140 @default.
- W4309263603 cites W2485910554 @default.
- W4309263603 cites W2530023109 @default.
- W4309263603 cites W2566919850 @default.
- W4309263603 cites W2573820523 @default.
- W4309263603 cites W2734563786 @default.
- W4309263603 cites W2750653488 @default.
- W4309263603 cites W2751416180 @default.
- W4309263603 cites W2803248828 @default.
- W4309263603 cites W2910129136 @default.
- W4309263603 cites W2911928150 @default.
- W4309263603 cites W2912523206 @default.
- W4309263603 cites W2931448452 @default.
- W4309263603 cites W2945282335 @default.
- W4309263603 cites W2949523314 @default.
- W4309263603 cites W2950398380 @default.
- W4309263603 cites W2970630833 @default.
- W4309263603 cites W2981638747 @default.
- W4309263603 cites W3006926844 @default.
- W4309263603 cites W3106214803 @default.
- W4309263603 cites W3118256323 @default.
- W4309263603 cites W4220721758 @default.
- W4309263603 cites W4292379725 @default.
- W4309263603 cites W4293484063 @default.
- W4309263603 cites W4295250096 @default.
- W4309263603 doi "https://doi.org/10.1101/2022.11.17.516946" @default.
- W4309263603 hasPublicationYear "2022" @default.
- W4309263603 type Work @default.
- W4309263603 citedByCount "3" @default.
- W4309263603 countsByYear W43092636032023 @default.
- W4309263603 crossrefType "posted-content" @default.
- W4309263603 hasAuthorship W4309263603A5010917720 @default.
- W4309263603 hasAuthorship W4309263603A5022267407 @default.
- W4309263603 hasAuthorship W4309263603A5053718440 @default.
- W4309263603 hasAuthorship W4309263603A5075839935 @default.
- W4309263603 hasBestOaLocation W43092636031 @default.
- W4309263603 hasConcept C120504264 @default.
- W4309263603 hasConcept C121332964 @default.
- W4309263603 hasConcept C12294094 @default.
- W4309263603 hasConcept C12554922 @default.
- W4309263603 hasConcept C1491633281 @default.
- W4309263603 hasConcept C152568617 @default.
- W4309263603 hasConcept C185544564 @default.
- W4309263603 hasConcept C185592680 @default.
- W4309263603 hasConcept C2778583388 @default.
- W4309263603 hasConcept C2779222958 @default.
- W4309263603 hasConcept C2781252693 @default.
- W4309263603 hasConcept C29537977 @default.
- W4309263603 hasConcept C3017597547 @default.
- W4309263603 hasConcept C55493867 @default.
- W4309263603 hasConcept C86803240 @default.