FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309266674> ?p ?o ?g. }

• W4309266674 endingPage "e31407" @default.
• W4309266674 startingPage "e31407" @default.
• W4309266674 abstract "To explore the molecular mechanisms of Weifuchun in the treatment of gastric intestinal metaplasia (GIM), we designed a preclinical pilot study to examine potential markers of disease progression based on alterations in the tongue flora.Total 27 patients with GIM were treated with Weifuchun for 4 weeks and 26 volunteers as controls. Tongue coating bacteria were profiled using 16S rDNA high-throughput sequencing. Serum pepsinogen I and II levels were detected using the latex immunoturbidimetric assay. The levels of serum trefoil factor I was detected by ELISA. Microplate-based quantification was used to detect serum total bile acid (TBA).After treatment, the relative abundance of 4 dominant tongue coating genera (Granulicatella, Gemella, Lachnoanaerobaculum, and Neisseria) increased significantly wheras Alloprevotella, [Eubacterium] nodatum group, Prevotell, and Ruminococcaceae UCG-014 decreased (P < .05). The results showed that Alloprevotella and 3 rare tongue coating genera (Lautropia, Treponema 2, and Aliihoeflea) might be potential markers or target flora for the treatment of GIM. Kyoto encyclopedia of genes and genomes (KEGG) function prediction analysis showed that Weifuchun may regulate bile secretion and folate biosynthesis in patients with GIM. The level of serum trefoil factor I decreased significantly in response to Weifuchun treatment, which was consistent with the decrease in folate biosynthesis predicted by KEGG.Weifuchun may restore the balance of tongue flora by decreasing the levels of serum trefoil factor I, thereby providing a new way to measuring the underlying effectiveness and potential mechanisms of action of this traditional Chinese medicinal compound in the treatment of GIM." @default.
• W4309266674 created "2022-11-25" @default.
• W4309266674 creator A5002764470 @default.
• W4309266674 creator A5021456815 @default.
• W4309266674 creator A5022096000 @default.
• W4309266674 creator A5040497140 @default.
• W4309266674 creator A5043985388 @default.
• W4309266674 creator A5046454314 @default.
• W4309266674 creator A5067873555 @default.
• W4309266674 creator A5067937579 @default.
• W4309266674 creator A5083637168 @default.
• W4309266674 date "2022-11-11" @default.
• W4309266674 modified "2023-10-14" @default.
• W4309266674 title "Weifuchun alters tongue flora and decreases serum trefoil factor I levels in gastric intestinal metaplasia: A CONSORT-compliant article" @default.
• W4309266674 cites W1860395514 @default.
• W4309266674 cites W1931918221 @default.
• W4309266674 cites W2073362503 @default.
• W4309266674 cites W2142127071 @default.
• W4309266674 cites W2152826661 @default.
• W4309266674 cites W2194293427 @default.
• W4309266674 cites W2591721313 @default.
• W4309266674 cites W2728383289 @default.
• W4309266674 cites W2739778494 @default.
• W4309266674 cites W2755818420 @default.
• W4309266674 cites W2761739984 @default.
• W4309266674 cites W2765111042 @default.
• W4309266674 cites W2791377533 @default.
• W4309266674 cites W2794046657 @default.
• W4309266674 cites W2801893886 @default.
• W4309266674 cites W2883290373 @default.
• W4309266674 cites W2889646458 @default.
• W4309266674 cites W2898605557 @default.
• W4309266674 cites W2901063891 @default.
• W4309266674 cites W2902487298 @default.
• W4309266674 cites W2902907693 @default.
• W4309266674 cites W2907319524 @default.
• W4309266674 cites W2913231321 @default.
• W4309266674 cites W2913765042 @default.
• W4309266674 cites W2927994835 @default.
• W4309266674 cites W2943606118 @default.
• W4309266674 cites W2992664796 @default.
• W4309266674 cites W2999829053 @default.
• W4309266674 cites W3002480603 @default.
• W4309266674 cites W3013982340 @default.
• W4309266674 cites W3041553755 @default.
• W4309266674 cites W3048029832 @default.
• W4309266674 cites W3081227736 @default.
• W4309266674 cites W3085493493 @default.
• W4309266674 cites W3087082774 @default.
• W4309266674 cites W3092466821 @default.
• W4309266674 cites W3173546915 @default.
• W4309266674 cites W3194773834 @default.
• W4309266674 cites W4205141291 @default.
• W4309266674 cites W4321515006 @default.
• W4309266674 doi "https://doi.org/10.1097/md.0000000000031407" @default.
• W4309266674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36397419" @default.
• W4309266674 hasPublicationYear "2022" @default.
• W4309266674 type Work @default.
• W4309266674 citedByCount "0" @default.
• W4309266674 crossrefType "journal-article" @default.
• W4309266674 hasAuthorship W4309266674A5002764470 @default.
• W4309266674 hasAuthorship W4309266674A5021456815 @default.
• W4309266674 hasAuthorship W4309266674A5022096000 @default.
• W4309266674 hasAuthorship W4309266674A5040497140 @default.
• W4309266674 hasAuthorship W4309266674A5043985388 @default.
• W4309266674 hasAuthorship W4309266674A5046454314 @default.
• W4309266674 hasAuthorship W4309266674A5067873555 @default.
• W4309266674 hasAuthorship W4309266674A5067937579 @default.
• W4309266674 hasAuthorship W4309266674A5083637168 @default.
• W4309266674 hasBestOaLocation W43092666741 @default.
• W4309266674 hasConcept C104317684 @default.
• W4309266674 hasConcept C126322002 @default.
• W4309266674 hasConcept C150194340 @default.
• W4309266674 hasConcept C152724338 @default.
• W4309266674 hasConcept C2775980262 @default.
• W4309266674 hasConcept C2780423288 @default.
• W4309266674 hasConcept C2987395477 @default.
• W4309266674 hasConcept C523546767 @default.
• W4309266674 hasConcept C54355233 @default.
• W4309266674 hasConcept C55493867 @default.
• W4309266674 hasConcept C71924100 @default.
• W4309266674 hasConcept C86803240 @default.
• W4309266674 hasConcept C89423630 @default.
• W4309266674 hasConcept C90924648 @default.
• W4309266674 hasConceptScore W4309266674C104317684 @default.
• W4309266674 hasConceptScore W4309266674C126322002 @default.
• W4309266674 hasConceptScore W4309266674C150194340 @default.
• W4309266674 hasConceptScore W4309266674C152724338 @default.
• W4309266674 hasConceptScore W4309266674C2775980262 @default.
• W4309266674 hasConceptScore W4309266674C2780423288 @default.
• W4309266674 hasConceptScore W4309266674C2987395477 @default.
• W4309266674 hasConceptScore W4309266674C523546767 @default.
• W4309266674 hasConceptScore W4309266674C54355233 @default.
• W4309266674 hasConceptScore W4309266674C55493867 @default.
• W4309266674 hasConceptScore W4309266674C71924100 @default.
• W4309266674 hasConceptScore W4309266674C86803240 @default.
• W4309266674 hasConceptScore W4309266674C89423630 @default.
• W4309266674 hasConceptScore W4309266674C90924648 @default.

• next