Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309269364> ?p ?o ?g. }
- W4309269364 endingPage "14149" @default.
- W4309269364 startingPage "14149" @default.
- W4309269364 abstract "Dieckol is a natural brown algal-derived polyphenol and its cytotoxic potential against various types of cancer cells has been studied. However, the effects of dieckol on autophagy in cancer cells remain unknown. Here, we show that dieckol inhibits the growth of A375 human melanoma cells by inducing apoptotic cell death, which is associated with lysosomal dysfunction and the inhibition of autophagic flux. Dieckol induces autophagosome accumulation by inhibiting autophagosome-lysosome fusion. Moreover, dieckol not only triggers lysosomal membrane permeabilization, followed by an increase in lysosomal pH and the inactivation of cathepsin B and D, but also causes the loss of mitochondrial membrane potential. Importantly, a cathepsin D inhibitor partially relieved dieckol-induced mitochondrial membrane impairment and caspase-mediated apoptosis. Collectively, our findings indicate that dieckol is a novel autophagy inhibitor that induces apoptosis-mediated cell death via lysosomal dysfunction and mitochondrial membrane impairment in A375 human melanoma cells. This suggests the novel potential value of dieckol as a chemotherapeutic drug candidate for melanoma treatment." @default.
- W4309269364 created "2022-11-25" @default.
- W4309269364 creator A5000897799 @default.
- W4309269364 creator A5029085217 @default.
- W4309269364 creator A5063850209 @default.
- W4309269364 date "2022-11-16" @default.
- W4309269364 modified "2023-09-30" @default.
- W4309269364 title "Dieckol Inhibits Autophagic Flux and Induces Apoptotic Cell Death in A375 Human Melanoma Cells via Lysosomal Dysfunction and Mitochondrial Membrane Impairment" @default.
- W4309269364 cites W1532805138 @default.
- W4309269364 cites W1938785803 @default.
- W4309269364 cites W1985821753 @default.
- W4309269364 cites W1991493131 @default.
- W4309269364 cites W1991692801 @default.
- W4309269364 cites W1992643412 @default.
- W4309269364 cites W1997184663 @default.
- W4309269364 cites W2001675597 @default.
- W4309269364 cites W2002424586 @default.
- W4309269364 cites W2008406529 @default.
- W4309269364 cites W2008590966 @default.
- W4309269364 cites W2012856926 @default.
- W4309269364 cites W2022286724 @default.
- W4309269364 cites W2023750468 @default.
- W4309269364 cites W2024119879 @default.
- W4309269364 cites W2025665129 @default.
- W4309269364 cites W2025684895 @default.
- W4309269364 cites W2026742987 @default.
- W4309269364 cites W2027091780 @default.
- W4309269364 cites W2035108035 @default.
- W4309269364 cites W2038049117 @default.
- W4309269364 cites W2055811314 @default.
- W4309269364 cites W2056182070 @default.
- W4309269364 cites W2064754939 @default.
- W4309269364 cites W2073865298 @default.
- W4309269364 cites W2075287142 @default.
- W4309269364 cites W2079585875 @default.
- W4309269364 cites W2080878773 @default.
- W4309269364 cites W2089616552 @default.
- W4309269364 cites W2106728581 @default.
- W4309269364 cites W2114480290 @default.
- W4309269364 cites W2118863192 @default.
- W4309269364 cites W2123073351 @default.
- W4309269364 cites W2128542677 @default.
- W4309269364 cites W2131040858 @default.
- W4309269364 cites W2140813472 @default.
- W4309269364 cites W2144096834 @default.
- W4309269364 cites W2144179778 @default.
- W4309269364 cites W2151294392 @default.
- W4309269364 cites W2155593291 @default.
- W4309269364 cites W2159754384 @default.
- W4309269364 cites W2164455918 @default.
- W4309269364 cites W2168711434 @default.
- W4309269364 cites W2332435224 @default.
- W4309269364 cites W2536199574 @default.
- W4309269364 cites W2576152476 @default.
- W4309269364 cites W2585804334 @default.
- W4309269364 cites W2595479073 @default.
- W4309269364 cites W2602035017 @default.
- W4309269364 cites W2736538915 @default.
- W4309269364 cites W2738996050 @default.
- W4309269364 cites W2768129277 @default.
- W4309269364 cites W2773258360 @default.
- W4309269364 cites W2774658967 @default.
- W4309269364 cites W2791484806 @default.
- W4309269364 cites W2800819803 @default.
- W4309269364 cites W2804861256 @default.
- W4309269364 cites W2810037075 @default.
- W4309269364 cites W2811403767 @default.
- W4309269364 cites W2888292224 @default.
- W4309269364 cites W2903362696 @default.
- W4309269364 cites W2905399276 @default.
- W4309269364 cites W2905862560 @default.
- W4309269364 cites W2920147611 @default.
- W4309269364 cites W2937680741 @default.
- W4309269364 cites W2957721022 @default.
- W4309269364 cites W2961617169 @default.
- W4309269364 cites W2969876208 @default.
- W4309269364 cites W2990474291 @default.
- W4309269364 cites W3010852055 @default.
- W4309269364 cites W3091907894 @default.
- W4309269364 cites W3133569201 @default.
- W4309269364 cites W3189129436 @default.
- W4309269364 cites W3198853168 @default.
- W4309269364 cites W4247679002 @default.
- W4309269364 cites W775311174 @default.
- W4309269364 doi "https://doi.org/10.3390/ijms232214149" @default.
- W4309269364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36430634" @default.
- W4309269364 hasPublicationYear "2022" @default.
- W4309269364 type Work @default.
- W4309269364 citedByCount "5" @default.
- W4309269364 countsByYear W43092693642022 @default.
- W4309269364 countsByYear W43092693642023 @default.
- W4309269364 crossrefType "journal-article" @default.
- W4309269364 hasAuthorship W4309269364A5000897799 @default.
- W4309269364 hasAuthorship W4309269364A5029085217 @default.
- W4309269364 hasAuthorship W4309269364A5063850209 @default.
- W4309269364 hasBestOaLocation W43092693641 @default.
- W4309269364 hasConcept C121608353 @default.
- W4309269364 hasConcept C173633252 @default.