Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309271178> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4309271178 endingPage "50" @default.
- W4309271178 startingPage "45" @default.
- W4309271178 abstract "The aim of the study was to assess the association of polymorphic variants CYP3A5*3 6986 A>G rs776746 and CYP3A4*22 rs35599367 C>T with the safety parameters of remdesivir therapy in patients with COVID-19. Material and methods . The study included 156 patients admitted to the City Clinical Hospital No. 15 of the Moscow Health Department with COVID-19 diagnosis, who received remdesivir as an antiviral drug. The frequency of adverse reactions (bradycardia, dyspeptic disorders), as well as various laboratory parameters (ALT, AST, creatinine, ferritin, interleukin-6, and d-dimer levels) were compared between the carriers of wild-type and polymorphic variants of the studied genes. Results . Carriers of CYP3A5*3 polymorphic variants (GA+AA) had higher ALT levels after the treatment with remdesivir than carriers of the wild variant (GG). When comparing the level of interleukin-6 after therapy with remdesivir, carriers of the polymorphic variant of the CYP3A4*22 (CT) gene had a significantly higher level of this cytokine. Conclusion . An association between the carriage of polymorphic variants of CYP3A5*3 and an increase in the level of liver enzymes was found. Polymorphic variants of CYP3A4*22 were associated with higher levels of interleukin-6. Additional pharmacogenetic studies are required to assess the possibilities of personalizing antiviral therapy for COVID-19." @default.
- W4309271178 created "2022-11-25" @default.
- W4309271178 creator A5000365411 @default.
- W4309271178 creator A5001405726 @default.
- W4309271178 creator A5009517815 @default.
- W4309271178 creator A5029243420 @default.
- W4309271178 creator A5064324725 @default.
- W4309271178 creator A5066844424 @default.
- W4309271178 creator A5077002462 @default.
- W4309271178 creator A5086639824 @default.
- W4309271178 creator A5087443498 @default.
- W4309271178 creator A5091837013 @default.
- W4309271178 date "2022-11-16" @default.
- W4309271178 modified "2023-09-29" @default.
- W4309271178 title "The Effect of Carriage of <i>CYP3A5*3</i> and <i>CYP3A4*22</i> Polymorphic Variants on the Safety of Remdesivir Therapy in Patients with COVID-19" @default.
- W4309271178 cites W1968180599 @default.
- W4309271178 cites W2007523308 @default.
- W4309271178 cites W2018643176 @default.
- W4309271178 cites W2031155689 @default.
- W4309271178 cites W2033139608 @default.
- W4309271178 cites W2080242218 @default.
- W4309271178 cites W2793022939 @default.
- W4309271178 cites W3005212621 @default.
- W4309271178 cites W3032677067 @default.
- W4309271178 cites W3040751560 @default.
- W4309271178 cites W3082947841 @default.
- W4309271178 cites W3087276070 @default.
- W4309271178 cites W3169516549 @default.
- W4309271178 cites W3213860519 @default.
- W4309271178 cites W3217516622 @default.
- W4309271178 doi "https://doi.org/10.37489/0235-2990-2022-67-7-8-45-50" @default.
- W4309271178 hasPublicationYear "2022" @default.
- W4309271178 type Work @default.
- W4309271178 citedByCount "0" @default.
- W4309271178 crossrefType "journal-article" @default.
- W4309271178 hasAuthorship W4309271178A5000365411 @default.
- W4309271178 hasAuthorship W4309271178A5001405726 @default.
- W4309271178 hasAuthorship W4309271178A5009517815 @default.
- W4309271178 hasAuthorship W4309271178A5029243420 @default.
- W4309271178 hasAuthorship W4309271178A5064324725 @default.
- W4309271178 hasAuthorship W4309271178A5066844424 @default.
- W4309271178 hasAuthorship W4309271178A5077002462 @default.
- W4309271178 hasAuthorship W4309271178A5086639824 @default.
- W4309271178 hasAuthorship W4309271178A5087443498 @default.
- W4309271178 hasAuthorship W4309271178A5091837013 @default.
- W4309271178 hasBestOaLocation W43092711781 @default.
- W4309271178 hasConcept C104317684 @default.
- W4309271178 hasConcept C126322002 @default.
- W4309271178 hasConcept C135763542 @default.
- W4309271178 hasConcept C149737253 @default.
- W4309271178 hasConcept C197934379 @default.
- W4309271178 hasConcept C2780306776 @default.
- W4309271178 hasConcept C54355233 @default.
- W4309271178 hasConcept C55775858 @default.
- W4309271178 hasConcept C71924100 @default.
- W4309271178 hasConcept C86803240 @default.
- W4309271178 hasConcept C90924648 @default.
- W4309271178 hasConceptScore W4309271178C104317684 @default.
- W4309271178 hasConceptScore W4309271178C126322002 @default.
- W4309271178 hasConceptScore W4309271178C135763542 @default.
- W4309271178 hasConceptScore W4309271178C149737253 @default.
- W4309271178 hasConceptScore W4309271178C197934379 @default.
- W4309271178 hasConceptScore W4309271178C2780306776 @default.
- W4309271178 hasConceptScore W4309271178C54355233 @default.
- W4309271178 hasConceptScore W4309271178C55775858 @default.
- W4309271178 hasConceptScore W4309271178C71924100 @default.
- W4309271178 hasConceptScore W4309271178C86803240 @default.
- W4309271178 hasConceptScore W4309271178C90924648 @default.
- W4309271178 hasIssue "7-8" @default.
- W4309271178 hasLocation W43092711781 @default.
- W4309271178 hasOpenAccess W4309271178 @default.
- W4309271178 hasPrimaryLocation W43092711781 @default.
- W4309271178 hasRelatedWork W1978889877 @default.
- W4309271178 hasRelatedWork W2165668090 @default.
- W4309271178 hasRelatedWork W2362703522 @default.
- W4309271178 hasRelatedWork W2369176854 @default.
- W4309271178 hasRelatedWork W2436880144 @default.
- W4309271178 hasRelatedWork W2571802179 @default.
- W4309271178 hasRelatedWork W2805837446 @default.
- W4309271178 hasRelatedWork W2884608079 @default.
- W4309271178 hasRelatedWork W2972096543 @default.
- W4309271178 hasRelatedWork W3029703232 @default.
- W4309271178 hasVolume "67" @default.
- W4309271178 isParatext "false" @default.
- W4309271178 isRetracted "false" @default.
- W4309271178 workType "article" @default.