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• W4309284993 endingPage "1673" @default.
• W4309284993 startingPage "1673" @default.
• W4309284993 abstract "While low serotonergic activity is often associated with psychological disorders such as depression, anxiety, mood, and personality disorders, variations in serotonin also contribute to normal personality differences. In this study, we investigated the role of blood DNA methylation levels at individual CpG sites of two key serotonergic genes (serotonin receptor gene 1A, HTR1A; serotonin transporter gene, SLC6A4) in predicting the personalities of captive chimpanzees. We found associations between methylation at 9/48 CpG sites with four personality dimensions: Dominance, Reactivity/Dependability, Agreeableness, and Openness. Directionality of effects were CpG location-dependent and confirmed a role of serotonergic methylation in reducing anxiety (Dominance) and aggression-related personality (Reactivity/Undependability) while simultaneously promoting prosocial (Agreeableness) and exploratory personalities (Openness). Although early-life adversity has been shown to impact serotonergic methylation patterns in other species, here, atypical early social rearing experiences only had a modest impact on CpG methylation levels in this chimpanzee sample. The precise environmental factors impacting serotonergic methylation in chimpanzees remain to be identified. Nevertheless, our study suggests a role in shaping natural variation in animal personalities. The results of this study offer a basis for future hypothesis-driven testing in additional populations and species to better understand the impact of ecology and evolution on complex behavioral traits." @default.
• W4309284993 created "2022-11-25" @default.
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• W4309284993 date "2022-11-17" @default.
• W4309284993 modified "2023-10-10" @default.
• W4309284993 title "The Role of Serotonergic Gene Methylation in Regulating Anxiety-Related Personality Traits in Chimpanzees" @default.
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• W4309284993 doi "https://doi.org/10.3390/biology11111673" @default.
• W4309284993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36421387" @default.
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