FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309287274> ?p ?o ?g. }

• W4309287274 endingPage "377" @default.
• W4309287274 startingPage "377" @default.
• W4309287274 abstract "Objectives: To develop a robust liquid chromatography-tandem mass spectrometry (LC–MS/MS) method to simultaneously measure seven human plasma androgens, namely testosterone (T), dihydrotestosterone (DHT), androstenedione (A4), dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), 11-ketotestosterone (11-KetoT), and 11β-hydroxytestosterone (11β-OHT). Design and Methods: Plasma was extracted via a solid phase extraction method, and the analytical performance of the assay was validated according to the Clinical & Laboratory Standards Institute guidelines. Overall, 73 apparently healthy volunteers were recruited to evaluate the distribution of these seven androgens; their levels in 25 females with acne and 33 obese females were also evaluated. Results: The developed method exhibited a good precision, with the total coefficient variations (CV) and the intra-assay CVs being within 10%. Furthermore, the recoveries of T, DHT, A4, DHEA, DHEAS, 11-KetoT, and 11β-OHT were 90.3–105.8, 88.7–98.1, 92.4–102.5, 90.5–106.7, 87.6–99.9, 93.3–105.3, and 90.2–104.4%, respectively, and no significant matrix effect was observed after internal standard correction (<20%). Moreover, the limits of quantification were 0.01, 0.01, 0.01, 0.10, 5.00, 0.02, and 0.02 ng/mL for T, DHT, A4, DHEA, DHEAS, 11-KetoT, and 11β-OHT, respectively, which are adequate for their accurate measurement in human plasma samples. It was also determined that patients diagnosed with acne had significantly higher levels of DHT, A4, and DHEAS, while those suffering from obesity had significantly higher levels of T and A4 but lower levels of DHT. Conclusions: A robust LC-MS/MS method for the simultaneous determination of seven androgens in plasma samples was successfully established and validated, which plays important roles in clinical application." @default.
• W4309287274 created "2022-11-25" @default.
• W4309287274 creator A5002198649 @default.
• W4309287274 creator A5009595843 @default.
• W4309287274 creator A5013041844 @default.
• W4309287274 creator A5018173194 @default.
• W4309287274 creator A5041490775 @default.
• W4309287274 creator A5048729839 @default.
• W4309287274 creator A5050017901 @default.
• W4309287274 creator A5061302667 @default.
• W4309287274 creator A5069133436 @default.
• W4309287274 creator A5076788576 @default.
• W4309287274 date "2022-11-17" @default.
• W4309287274 modified "2023-10-17" @default.
• W4309287274 title "Establishing and Verifying a Robust Liquid Chromatography-Tandem Mass Spectrometry Method to Simultaneously Measure Seven Androgens Present in Plasma Samples" @default.
• W4309287274 cites W1917696566 @default.
• W4309287274 cites W1980808116 @default.
• W4309287274 cites W2023836656 @default.
• W4309287274 cites W2092008641 @default.
• W4309287274 cites W2093386301 @default.
• W4309287274 cites W2096237552 @default.
• W4309287274 cites W2120973019 @default.
• W4309287274 cites W2128317410 @default.
• W4309287274 cites W2134271596 @default.
• W4309287274 cites W2162895515 @default.
• W4309287274 cites W2165889715 @default.
• W4309287274 cites W2485265936 @default.
• W4309287274 cites W2494789486 @default.
• W4309287274 cites W2590383052 @default.
• W4309287274 cites W2610430925 @default.
• W4309287274 cites W2792572687 @default.
• W4309287274 cites W2895902840 @default.
• W4309287274 cites W2901588957 @default.
• W4309287274 cites W2907312795 @default.
• W4309287274 cites W2945127529 @default.
• W4309287274 cites W3008600709 @default.
• W4309287274 cites W3034089088 @default.
• W4309287274 cites W3111066920 @default.
• W4309287274 cites W3113634989 @default.
• W4309287274 cites W826887575 @default.
• W4309287274 doi "https://doi.org/10.3390/separations9110377" @default.
• W4309287274 hasPublicationYear "2022" @default.
• W4309287274 type Work @default.
• W4309287274 citedByCount "2" @default.
• W4309287274 countsByYear W43092872742023 @default.
• W4309287274 crossrefType "journal-article" @default.
• W4309287274 hasAuthorship W4309287274A5002198649 @default.
• W4309287274 hasAuthorship W4309287274A5009595843 @default.
• W4309287274 hasAuthorship W4309287274A5013041844 @default.
• W4309287274 hasAuthorship W4309287274A5018173194 @default.
• W4309287274 hasAuthorship W4309287274A5041490775 @default.
• W4309287274 hasAuthorship W4309287274A5048729839 @default.
• W4309287274 hasAuthorship W4309287274A5050017901 @default.
• W4309287274 hasAuthorship W4309287274A5061302667 @default.
• W4309287274 hasAuthorship W4309287274A5069133436 @default.
• W4309287274 hasAuthorship W4309287274A5076788576 @default.
• W4309287274 hasBestOaLocation W43092872741 @default.
• W4309287274 hasConcept C126322002 @default.
• W4309287274 hasConcept C134018914 @default.
• W4309287274 hasConcept C162356407 @default.
• W4309287274 hasConcept C185592680 @default.
• W4309287274 hasConcept C2776683971 @default.
• W4309287274 hasConcept C2776992908 @default.
• W4309287274 hasConcept C2777911890 @default.
• W4309287274 hasConcept C2779279991 @default.
• W4309287274 hasConcept C2779881493 @default.
• W4309287274 hasConcept C2780657110 @default.
• W4309287274 hasConcept C31827203 @default.
• W4309287274 hasConcept C43617362 @default.
• W4309287274 hasConcept C64489805 @default.
• W4309287274 hasConcept C71315377 @default.
• W4309287274 hasConcept C71924100 @default.
• W4309287274 hasConceptScore W4309287274C126322002 @default.
• W4309287274 hasConceptScore W4309287274C134018914 @default.
• W4309287274 hasConceptScore W4309287274C162356407 @default.
• W4309287274 hasConceptScore W4309287274C185592680 @default.
• W4309287274 hasConceptScore W4309287274C2776683971 @default.
• W4309287274 hasConceptScore W4309287274C2776992908 @default.
• W4309287274 hasConceptScore W4309287274C2777911890 @default.
• W4309287274 hasConceptScore W4309287274C2779279991 @default.
• W4309287274 hasConceptScore W4309287274C2779881493 @default.
• W4309287274 hasConceptScore W4309287274C2780657110 @default.
• W4309287274 hasConceptScore W4309287274C31827203 @default.
• W4309287274 hasConceptScore W4309287274C43617362 @default.
• W4309287274 hasConceptScore W4309287274C64489805 @default.
• W4309287274 hasConceptScore W4309287274C71315377 @default.
• W4309287274 hasConceptScore W4309287274C71924100 @default.
• W4309287274 hasIssue "11" @default.
• W4309287274 hasLocation W43092872741 @default.
• W4309287274 hasOpenAccess W4309287274 @default.
• W4309287274 hasPrimaryLocation W43092872741 @default.
• W4309287274 hasRelatedWork W1979102595 @default.
• W4309287274 hasRelatedWork W2002995968 @default.
• W4309287274 hasRelatedWork W2024718203 @default.
• W4309287274 hasRelatedWork W2038277505 @default.
• W4309287274 hasRelatedWork W2053511509 @default.
• W4309287274 hasRelatedWork W2067172377 @default.
• W4309287274 hasRelatedWork W2067765841 @default.

• next