Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309293826> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4309293826 endingPage "102716" @default.
- W4309293826 startingPage "102716" @default.
- W4309293826 abstract "Adipocyte hyperplasia and hypertrophy are the two main processes contributing to adipose tissue expansion, yet the mechanisms that regulate and balance their involvement in obesity are incompletely understood. Activin B/GDF-3 receptor ALK7 is expressed in mature adipocytes, and promotes adipocyte hypertrophy upon nutrient overload by suppressing adrenergic signaling and lipolysis. In contrast, the role of ALK4, the canonical pan-activin receptor, in adipose tissue is unknown. Here we report that, unlike ALK7, ALK4 is preferentially expressed in adipocyte precursors, where it suppresses differentiation, allowing proliferation and adipose tissue expansion. ALK4 expression in adipose tissue increases upon nutrient overload and positively correlates with fat depot mass and body weight, suggesting a role in adipose tissue hyperplasia during obesity. Mechanistically, ALK4 signaling suppresses expression of CEBPα and PPARγ, two master regulators of adipocyte differentiation. Conversely, ALK4 deletion enhances CEBPα/PPARγ expression and induces premature adipocyte differentiation, which can be rescued by CEBPα knock-down. These results clarify the function of ALK4 in adipose tissue and highlight the contrasting roles of the two activin receptors in the regulation of adipocyte hyperplasia and hypertrophy during obesity." @default.
- W4309293826 created "2022-11-25" @default.
- W4309293826 creator A5001553964 @default.
- W4309293826 creator A5017784944 @default.
- W4309293826 creator A5033116502 @default.
- W4309293826 creator A5055040328 @default.
- W4309293826 creator A5061389667 @default.
- W4309293826 date "2023-01-01" @default.
- W4309293826 modified "2023-10-03" @default.
- W4309293826 title "Activin receptor ALK4 promotes adipose tissue hyperplasia by suppressing differentiation of adipocyte precursors" @default.
- W4309293826 cites W1970519791 @default.
- W4309293826 cites W2000524154 @default.
- W4309293826 cites W2004861205 @default.
- W4309293826 cites W2016329340 @default.
- W4309293826 cites W2017292651 @default.
- W4309293826 cites W2025448236 @default.
- W4309293826 cites W2031361161 @default.
- W4309293826 cites W2032182024 @default.
- W4309293826 cites W2032830244 @default.
- W4309293826 cites W2047683706 @default.
- W4309293826 cites W2080382177 @default.
- W4309293826 cites W2082835899 @default.
- W4309293826 cites W2089319338 @default.
- W4309293826 cites W2094607573 @default.
- W4309293826 cites W2107500412 @default.
- W4309293826 cites W2109973423 @default.
- W4309293826 cites W2143893727 @default.
- W4309293826 cites W2149393334 @default.
- W4309293826 cites W2149823848 @default.
- W4309293826 cites W2239531983 @default.
- W4309293826 cites W2346401028 @default.
- W4309293826 cites W2893651910 @default.
- W4309293826 cites W2988827730 @default.
- W4309293826 cites W3084740474 @default.
- W4309293826 cites W3180182317 @default.
- W4309293826 cites W4283322170 @default.
- W4309293826 doi "https://doi.org/10.1016/j.jbc.2022.102716" @default.
- W4309293826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36403856" @default.
- W4309293826 hasPublicationYear "2023" @default.
- W4309293826 type Work @default.
- W4309293826 citedByCount "0" @default.
- W4309293826 crossrefType "journal-article" @default.
- W4309293826 hasAuthorship W4309293826A5001553964 @default.
- W4309293826 hasAuthorship W4309293826A5017784944 @default.
- W4309293826 hasAuthorship W4309293826A5033116502 @default.
- W4309293826 hasAuthorship W4309293826A5055040328 @default.
- W4309293826 hasAuthorship W4309293826A5061389667 @default.
- W4309293826 hasBestOaLocation W43092938262 @default.
- W4309293826 hasConcept C126322002 @default.
- W4309293826 hasConcept C134018914 @default.
- W4309293826 hasConcept C140985366 @default.
- W4309293826 hasConcept C170493617 @default.
- W4309293826 hasConcept C171089720 @default.
- W4309293826 hasConcept C185592680 @default.
- W4309293826 hasConcept C2776175234 @default.
- W4309293826 hasConcept C2777562237 @default.
- W4309293826 hasConcept C71924100 @default.
- W4309293826 hasConcept C86803240 @default.
- W4309293826 hasConcept C95444343 @default.
- W4309293826 hasConceptScore W4309293826C126322002 @default.
- W4309293826 hasConceptScore W4309293826C134018914 @default.
- W4309293826 hasConceptScore W4309293826C140985366 @default.
- W4309293826 hasConceptScore W4309293826C170493617 @default.
- W4309293826 hasConceptScore W4309293826C171089720 @default.
- W4309293826 hasConceptScore W4309293826C185592680 @default.
- W4309293826 hasConceptScore W4309293826C2776175234 @default.
- W4309293826 hasConceptScore W4309293826C2777562237 @default.
- W4309293826 hasConceptScore W4309293826C71924100 @default.
- W4309293826 hasConceptScore W4309293826C86803240 @default.
- W4309293826 hasConceptScore W4309293826C95444343 @default.
- W4309293826 hasFunder F4320320697 @default.
- W4309293826 hasIssue "1" @default.
- W4309293826 hasLocation W43092938261 @default.
- W4309293826 hasLocation W43092938262 @default.
- W4309293826 hasLocation W43092938263 @default.
- W4309293826 hasLocation W43092938264 @default.
- W4309293826 hasOpenAccess W4309293826 @default.
- W4309293826 hasPrimaryLocation W43092938261 @default.
- W4309293826 hasRelatedWork W1964688190 @default.
- W4309293826 hasRelatedWork W1973838972 @default.
- W4309293826 hasRelatedWork W1976234278 @default.
- W4309293826 hasRelatedWork W1979277576 @default.
- W4309293826 hasRelatedWork W2039472462 @default.
- W4309293826 hasRelatedWork W2045339060 @default.
- W4309293826 hasRelatedWork W2048359366 @default.
- W4309293826 hasRelatedWork W2068408721 @default.
- W4309293826 hasRelatedWork W2125103862 @default.
- W4309293826 hasRelatedWork W291138652 @default.
- W4309293826 hasVolume "299" @default.
- W4309293826 isParatext "false" @default.
- W4309293826 isRetracted "false" @default.
- W4309293826 workType "article" @default.