FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309306507> ?p ?o ?g. }

• W4309306507 endingPage "e0277849" @default.
• W4309306507 startingPage "e0277849" @default.
• W4309306507 abstract "Asthma is a polygenic chronic inflammatory respiratory disease devastating the quality of life and state economies. Therefore, utilization of natural products as a therapeutic approach has attained wider consideration for development of novel drugs for asthma management. Bromelain, a mixture of natural bioactive cysteine proteases abundantly found in pineapple stem, has allured attention for its pharmacological activities. However, poor stability in gastric milieu, high dose and immunogenicity associated with prolonged use hinders its oral use. Therefore, need exists to explore alternative route of bromelain administration to achieve its plausible benefits. The present study investigated the preclinical prospects of nasal administration of bromelain on systemic bioavailability, tissue distribution and it's in vivo anti-histaminic, bronchodilator and anti-asthmatic activity in animal models. Pharmacokinetic studies revealed 1.43-fold higher relative bioavailability with faster absorption of bromelain on nasal administration at one-fourth oral dose. The enhanced cellular uptake and localization of bromelain in tissues of lung was observed significantly. Furthermore, faster onset and enhanced antihistaminic, bronchodilator and anti-asthmatic activity on bromelain's nasal administration signified faster absorption and higher in vivo stability of bromelain. Nasal administration significantly achieved decrease in level of oxidative and immunological markers along with restoration of antioxidant enzymes at considerably one-fourth dose administered orally. These findings distinctly manifested that nasal administration could be a substantial and effective route for bromelain delivery with enduring competency in asthma management." @default.
• W4309306507 created "2022-11-26" @default.
• W4309306507 creator A5002216157 @default.
• W4309306507 creator A5005331846 @default.
• W4309306507 creator A5088506574 @default.
• W4309306507 date "2022-11-18" @default.
• W4309306507 modified "2023-10-17" @default.
• W4309306507 title "Implications of nasal delivery of bromelain on its pharmacokinetics, tissue distribution and pharmacodynamic profile—A preclinical study" @default.
• W4309306507 cites W1901709268 @default.
• W4309306507 cites W1956777959 @default.
• W4309306507 cites W1971604889 @default.
• W4309306507 cites W1977368405 @default.
• W4309306507 cites W1980105210 @default.
• W4309306507 cites W1987877959 @default.
• W4309306507 cites W2085067919 @default.
• W4309306507 cites W2137550723 @default.
• W4309306507 cites W2168417520 @default.
• W4309306507 cites W2308077172 @default.
• W4309306507 cites W2575722517 @default.
• W4309306507 cites W2604995316 @default.
• W4309306507 cites W2610255728 @default.
• W4309306507 cites W2613006260 @default.
• W4309306507 cites W2744303159 @default.
• W4309306507 cites W2754586014 @default.
• W4309306507 cites W2781523026 @default.
• W4309306507 cites W2782856880 @default.
• W4309306507 cites W2784923811 @default.
• W4309306507 cites W2786658869 @default.
• W4309306507 cites W2802589401 @default.
• W4309306507 cites W2805490366 @default.
• W4309306507 cites W2864307404 @default.
• W4309306507 cites W2898625779 @default.
• W4309306507 cites W2902110412 @default.
• W4309306507 cites W2909669903 @default.
• W4309306507 cites W2910878930 @default.
• W4309306507 cites W2912228197 @default.
• W4309306507 cites W2919437997 @default.
• W4309306507 cites W2997145899 @default.
• W4309306507 cites W3005558656 @default.
• W4309306507 cites W3013866917 @default.
• W4309306507 cites W3026239379 @default.
• W4309306507 cites W3028847646 @default.
• W4309306507 cites W3047067104 @default.
• W4309306507 cites W3085298651 @default.
• W4309306507 cites W3111446023 @default.
• W4309306507 cites W3151703478 @default.
• W4309306507 cites W3170224159 @default.
• W4309306507 cites W3195097065 @default.
• W4309306507 cites W4212888410 @default.
• W4309306507 cites W4238760231 @default.
• W4309306507 doi "https://doi.org/10.1371/journal.pone.0277849" @default.
• W4309306507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36399461" @default.
• W4309306507 hasPublicationYear "2022" @default.
• W4309306507 type Work @default.
• W4309306507 citedByCount "1" @default.
• W4309306507 countsByYear W43093065072023 @default.
• W4309306507 crossrefType "journal-article" @default.
• W4309306507 hasAuthorship W4309306507A5002216157 @default.
• W4309306507 hasAuthorship W4309306507A5005331846 @default.
• W4309306507 hasAuthorship W4309306507A5088506574 @default.
• W4309306507 hasBestOaLocation W43093065071 @default.
• W4309306507 hasConcept C111113717 @default.
• W4309306507 hasConcept C112705442 @default.
• W4309306507 hasConcept C150903083 @default.
• W4309306507 hasConcept C181199279 @default.
• W4309306507 hasConcept C181389837 @default.
• W4309306507 hasConcept C185592680 @default.
• W4309306507 hasConcept C203014093 @default.
• W4309306507 hasConcept C207001950 @default.
• W4309306507 hasConcept C2776042228 @default.
• W4309306507 hasConcept C2776714187 @default.
• W4309306507 hasConcept C2777056448 @default.
• W4309306507 hasConcept C2777334355 @default.
• W4309306507 hasConcept C2781018748 @default.
• W4309306507 hasConcept C55493867 @default.
• W4309306507 hasConcept C71924100 @default.
• W4309306507 hasConcept C85663871 @default.
• W4309306507 hasConcept C86803240 @default.
• W4309306507 hasConcept C98274493 @default.
• W4309306507 hasConceptScore W4309306507C111113717 @default.
• W4309306507 hasConceptScore W4309306507C112705442 @default.
• W4309306507 hasConceptScore W4309306507C150903083 @default.
• W4309306507 hasConceptScore W4309306507C181199279 @default.
• W4309306507 hasConceptScore W4309306507C181389837 @default.
• W4309306507 hasConceptScore W4309306507C185592680 @default.
• W4309306507 hasConceptScore W4309306507C203014093 @default.
• W4309306507 hasConceptScore W4309306507C207001950 @default.
• W4309306507 hasConceptScore W4309306507C2776042228 @default.
• W4309306507 hasConceptScore W4309306507C2776714187 @default.
• W4309306507 hasConceptScore W4309306507C2777056448 @default.
• W4309306507 hasConceptScore W4309306507C2777334355 @default.
• W4309306507 hasConceptScore W4309306507C2781018748 @default.
• W4309306507 hasConceptScore W4309306507C55493867 @default.
• W4309306507 hasConceptScore W4309306507C71924100 @default.
• W4309306507 hasConceptScore W4309306507C85663871 @default.
• W4309306507 hasConceptScore W4309306507C86803240 @default.
• W4309306507 hasConceptScore W4309306507C98274493 @default.
• W4309306507 hasIssue "11" @default.

• next