FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309311937> ?p ?o ?g. }

• W4309311937 abstract "Background: Hemorrhagic shock (HS) is a type of hypovolemic shock characterized by hemodynamic instability, tissue hypoperfusion and cellular hypoxia. In pathophysiology, the gradual accumulation of reactive oxygen species (ROS) damages the mitochondria, leading to irreversible cell damage and the release of endogenous damage-associated molecular patterns (DAMPs) including mitochondrial DAMPs (MTDs), eventually triggering the inflammatory response. The novel mitochondria-targeted antioxidant SkQ1 (Visomitin) effectively eliminate excessive intracellular ROS and exhibits anti-inflammatory effects; however, the specific role of SkQ1 in HS has not yet been explicated. Methods and results: A 40% fixed-blood-loss HS rat model was established in this study. Transmission electron microscopy showed that after HS, the myocardial mitochondrial ultrastructure was damaged and the mtDNA release in circulation was increased and the differentially expressed genes were significantly enriched in mitochondrial and ROS-related pathways. Mitochondria-targeted antioxidant SkQ1 attenuated the increased ROS induced by HS in myocardial tissues and by oxygen-glucose deprivation (OGD) in cardiomyocytes. Ultrastructurally, SkQ1 protected the myocardial mitochondrial structure and reduced the release of the peripheral blood mtDNA after HS. RNA-seq transcriptome analysis showed that 56.5% of the inflammation-related genes, which altered after HS, could be significantly reversed after SkQ1 treatment. Moreover, ELISA indicated that SkQ1 significantly reversed the HS-induced increases in the TNF-α, IL-6, and MCP-1 protein levels in rat peripheral blood. Conclusion: HS causes damage to the rat myocardial mitochondrial structure, increases mtDNA release and ROS contents, activates the mitochondrial and ROS-related pathways, and induces systemic inflammatory response. The mitochondrial antioxidant SkQ1 can improve rat myocardial mitochondria ultrastructure, reduce mtDNA and ROS contents, and decrease inflammation by protecting myocardial mitochondria, thereby playing a novel protective role in HS." @default.
• W4309311937 created "2022-11-26" @default.
• W4309311937 creator A5006818041 @default.
• W4309311937 creator A5007976433 @default.
• W4309311937 creator A5009001152 @default.
• W4309311937 creator A5022222545 @default.
• W4309311937 creator A5029360035 @default.
• W4309311937 creator A5031791103 @default.
• W4309311937 creator A5035856815 @default.
• W4309311937 creator A5040776117 @default.
• W4309311937 creator A5053797937 @default.
• W4309311937 creator A5055191616 @default.
• W4309311937 creator A5081427229 @default.
• W4309311937 creator A5081675173 @default.
• W4309311937 creator A5089285607 @default.
• W4309311937 date "2022-11-16" @default.
• W4309311937 modified "2023-10-16" @default.
• W4309311937 title "Mitochondrial antioxidant SkQ1 decreases inflammation following hemorrhagic shock by protecting myocardial mitochondria" @default.
• W4309311937 cites W1493344779 @default.
• W4309311937 cites W1994856368 @default.
• W4309311937 cites W2032478715 @default.
• W4309311937 cites W2044926927 @default.
• W4309311937 cites W2055820092 @default.
• W4309311937 cites W2060157902 @default.
• W4309311937 cites W2090857020 @default.
• W4309311937 cites W2120146385 @default.
• W4309311937 cites W2125065061 @default.
• W4309311937 cites W2134219545 @default.
• W4309311937 cites W2156382704 @default.
• W4309311937 cites W2159613622 @default.
• W4309311937 cites W2162248789 @default.
• W4309311937 cites W2163085099 @default.
• W4309311937 cites W2276884332 @default.
• W4309311937 cites W2295688414 @default.
• W4309311937 cites W2577928160 @default.
• W4309311937 cites W2749777324 @default.
• W4309311937 cites W2766855295 @default.
• W4309311937 cites W2790987004 @default.
• W4309311937 cites W2802161900 @default.
• W4309311937 cites W2884912010 @default.
• W4309311937 cites W2889958511 @default.
• W4309311937 cites W2889991879 @default.
• W4309311937 cites W2902944709 @default.
• W4309311937 cites W2907305043 @default.
• W4309311937 cites W2972054047 @default.
• W4309311937 cites W2981256586 @default.
• W4309311937 cites W3113188483 @default.
• W4309311937 cites W3132645728 @default.
• W4309311937 cites W3194347240 @default.
• W4309311937 cites W3209927132 @default.
• W4309311937 cites W3216214937 @default.
• W4309311937 cites W4211184849 @default.
• W4309311937 cites W4220883160 @default.
• W4309311937 cites W4226146129 @default.
• W4309311937 cites W4233741605 @default.
• W4309311937 doi "https://doi.org/10.3389/fphys.2022.1047909" @default.
• W4309311937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36467681" @default.
• W4309311937 hasPublicationYear "2022" @default.
• W4309311937 type Work @default.
• W4309311937 citedByCount "4" @default.
• W4309311937 countsByYear W43093119372023 @default.
• W4309311937 crossrefType "journal-article" @default.
• W4309311937 hasAuthorship W4309311937A5006818041 @default.
• W4309311937 hasAuthorship W4309311937A5007976433 @default.
• W4309311937 hasAuthorship W4309311937A5009001152 @default.
• W4309311937 hasAuthorship W4309311937A5022222545 @default.
• W4309311937 hasAuthorship W4309311937A5029360035 @default.
• W4309311937 hasAuthorship W4309311937A5031791103 @default.
• W4309311937 hasAuthorship W4309311937A5035856815 @default.
• W4309311937 hasAuthorship W4309311937A5040776117 @default.
• W4309311937 hasAuthorship W4309311937A5053797937 @default.
• W4309311937 hasAuthorship W4309311937A5055191616 @default.
• W4309311937 hasAuthorship W4309311937A5081427229 @default.
• W4309311937 hasAuthorship W4309311937A5081675173 @default.
• W4309311937 hasAuthorship W4309311937A5089285607 @default.
• W4309311937 hasBestOaLocation W43093119371 @default.
• W4309311937 hasConcept C104317684 @default.
• W4309311937 hasConcept C134018914 @default.
• W4309311937 hasConcept C185592680 @default.
• W4309311937 hasConcept C203014093 @default.
• W4309311937 hasConcept C24586158 @default.
• W4309311937 hasConcept C2776151105 @default.
• W4309311937 hasConcept C2776914184 @default.
• W4309311937 hasConcept C2778175917 @default.
• W4309311937 hasConcept C28859421 @default.
• W4309311937 hasConcept C48349386 @default.
• W4309311937 hasConcept C55493867 @default.
• W4309311937 hasConcept C86803240 @default.
• W4309311937 hasConcept C95444343 @default.
• W4309311937 hasConceptScore W4309311937C104317684 @default.
• W4309311937 hasConceptScore W4309311937C134018914 @default.
• W4309311937 hasConceptScore W4309311937C185592680 @default.
• W4309311937 hasConceptScore W4309311937C203014093 @default.
• W4309311937 hasConceptScore W4309311937C24586158 @default.
• W4309311937 hasConceptScore W4309311937C2776151105 @default.
• W4309311937 hasConceptScore W4309311937C2776914184 @default.
• W4309311937 hasConceptScore W4309311937C2778175917 @default.
• W4309311937 hasConceptScore W4309311937C28859421 @default.
• W4309311937 hasConceptScore W4309311937C48349386 @default.
• W4309311937 hasConceptScore W4309311937C55493867 @default.

• next