Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309333412> ?p ?o ?g. }
- W4309333412 endingPage "100820" @default.
- W4309333412 startingPage "100820" @default.
- W4309333412 abstract "Ideal therapies for regenerative medicine or healthy aging require healthy organ growth and rejuvenation, but no organ-level approach is currently available. Using Mycobacterium leprae (ML) with natural partial cellular reprogramming capacity and its animal host nine-banded armadillos, we present an evolutionarily refined model of adult liver growth and regeneration. In infected armadillos, ML reprogram the entire liver and significantly increase total liver/body weight ratio by increasing healthy liver lobules, including hepatocyte proliferation and proportionate expansion of vasculature, and biliary systems. ML-infected livers are microarchitecturally and functionally normal without damage, fibrosis, or tumorigenesis. Bacteria-induced reprogramming reactivates liver progenitor/developmental/fetal genes and upregulates growth-, metabolism-, and anti-aging-associated markers with minimal change in senescence and tumorigenic genes, suggesting bacterial hijacking of homeostatic, regeneration pathways to promote de novo organogenesis. This may facilitate the unraveling of endogenous pathways that effectively and safely re-engage liver organ growth, with broad therapeutic implications including organ regeneration and rejuvenation." @default.
- W4309333412 created "2022-11-26" @default.
- W4309333412 creator A5009463330 @default.
- W4309333412 creator A5020207042 @default.
- W4309333412 creator A5021912570 @default.
- W4309333412 creator A5022439912 @default.
- W4309333412 creator A5058035166 @default.
- W4309333412 creator A5072803795 @default.
- W4309333412 creator A5075504538 @default.
- W4309333412 creator A5080104851 @default.
- W4309333412 date "2022-11-01" @default.
- W4309333412 modified "2023-09-26" @default.
- W4309333412 title "In vivo partial reprogramming by bacteria promotes adult liver organ growth without fibrosis and tumorigenesis" @default.
- W4309333412 cites W195805106 @default.
- W4309333412 cites W1964164128 @default.
- W4309333412 cites W1966995556 @default.
- W4309333412 cites W1969353942 @default.
- W4309333412 cites W1987882040 @default.
- W4309333412 cites W1994942890 @default.
- W4309333412 cites W1999800789 @default.
- W4309333412 cites W2005352397 @default.
- W4309333412 cites W2006111363 @default.
- W4309333412 cites W2006866077 @default.
- W4309333412 cites W2012034410 @default.
- W4309333412 cites W2013170430 @default.
- W4309333412 cites W2022687771 @default.
- W4309333412 cites W2023293712 @default.
- W4309333412 cites W2024763248 @default.
- W4309333412 cites W2027227358 @default.
- W4309333412 cites W2028827115 @default.
- W4309333412 cites W2036897871 @default.
- W4309333412 cites W2036913140 @default.
- W4309333412 cites W2045333877 @default.
- W4309333412 cites W2048194168 @default.
- W4309333412 cites W2051454588 @default.
- W4309333412 cites W2055677100 @default.
- W4309333412 cites W2059908753 @default.
- W4309333412 cites W2060620712 @default.
- W4309333412 cites W2076325336 @default.
- W4309333412 cites W2077050387 @default.
- W4309333412 cites W2079748214 @default.
- W4309333412 cites W2086682233 @default.
- W4309333412 cites W2096086497 @default.
- W4309333412 cites W2102278945 @default.
- W4309333412 cites W2104005232 @default.
- W4309333412 cites W2105787356 @default.
- W4309333412 cites W2108527886 @default.
- W4309333412 cites W2117387977 @default.
- W4309333412 cites W2118676491 @default.
- W4309333412 cites W2125987139 @default.
- W4309333412 cites W2132066847 @default.
- W4309333412 cites W2147604272 @default.
- W4309333412 cites W2154431984 @default.
- W4309333412 cites W2164217177 @default.
- W4309333412 cites W2167155851 @default.
- W4309333412 cites W2167279371 @default.
- W4309333412 cites W2339774221 @default.
- W4309333412 cites W2441337908 @default.
- W4309333412 cites W2470627655 @default.
- W4309333412 cites W2510875395 @default.
- W4309333412 cites W2562001879 @default.
- W4309333412 cites W2563604790 @default.
- W4309333412 cites W2580035316 @default.
- W4309333412 cites W2581500657 @default.
- W4309333412 cites W2599212387 @default.
- W4309333412 cites W265577697 @default.
- W4309333412 cites W2725319743 @default.
- W4309333412 cites W2782460017 @default.
- W4309333412 cites W2796867095 @default.
- W4309333412 cites W2800624356 @default.
- W4309333412 cites W2801674050 @default.
- W4309333412 cites W2893835498 @default.
- W4309333412 cites W2896518632 @default.
- W4309333412 cites W2908922892 @default.
- W4309333412 cites W2913467156 @default.
- W4309333412 cites W2959566316 @default.
- W4309333412 cites W2963310788 @default.
- W4309333412 cites W2963695515 @default.
- W4309333412 cites W2968954657 @default.
- W4309333412 cites W2980506202 @default.
- W4309333412 cites W3012870529 @default.
- W4309333412 cites W3014402470 @default.
- W4309333412 cites W3035918211 @default.
- W4309333412 cites W3047433286 @default.
- W4309333412 cites W3092891725 @default.
- W4309333412 cites W3108896277 @default.
- W4309333412 cites W3130345333 @default.
- W4309333412 cites W3132549301 @default.
- W4309333412 cites W3159466615 @default.
- W4309333412 cites W3165546848 @default.
- W4309333412 cites W3196329163 @default.
- W4309333412 cites W3200928356 @default.
- W4309333412 cites W4210995852 @default.
- W4309333412 cites W4211183069 @default.
- W4309333412 cites W4220874593 @default.
- W4309333412 cites W4225004758 @default.
- W4309333412 cites W4225567851 @default.
- W4309333412 cites W4232620598 @default.