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- W4309335018 abstract "Adenosine triphosphate (ATP) is a signalling molecule acting as a neurotransmitter but also as a danger signal. The purinergic receptor P2X7 is the main sensor of high concentration of ATP released by damaged cells. In the eye, P2X7 is expressed by resident microglia and immune cells that infiltrate the retina in disease such as age-related macular degeneration (AMD), a degenerative retinal disease, and uveitis, an inflammatory eye disease. Activation of P2X7 is involved in several physiological and pathological processes: phagocytosis, activation of the inflammasome NLRP3, release of pro-inflammatory mediators and cell death. The aim of this review is to discuss the potential involvement of P2X7 in the development of AMD and uveitis." @default.
- W4309335018 created "2022-11-26" @default.
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- W4309335018 date "2023-02-01" @default.
- W4309335018 modified "2023-09-25" @default.
- W4309335018 title "P2X7-dependent immune pathways in retinal diseases" @default.
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- W4309335018 doi "https://doi.org/10.1016/j.neuropharm.2022.109332" @default.
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