Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309337510> ?p ?o ?g. }
- W4309337510 endingPage "134.e5" @default.
- W4309337510 startingPage "124" @default.
- W4309337510 abstract "Successful colonization of a host requires bacterial adaptation through genetic and population changes that are incompletely defined. Using chromosomal barcoding and high-throughput sequencing, we investigate the population dynamics of Streptococcus pneumoniae during infant mouse colonization. Within 1 day post inoculation, diversity was reduced >35-fold with expansion of a single clonal lineage. This loss of diversity was not due to immune factors, microbiota, or exclusive genetic drift. Rather, bacteriocins induced by the BlpC-quorum sensing pheromone resulted in predation of kin cells. In this intra-strain competition, the subpopulation reaching a quorum likely eliminates others that have yet to activate the blp locus. Additionally, this reduced diversity restricts the number of unique clones that establish colonization during transmission between hosts. Genetic variation in the blp locus was also associated with altered transmissibility in a human population, further underscoring the importance of BlpC in clonal selection and its role as a selfish element." @default.
- W4309337510 created "2022-11-26" @default.
- W4309337510 creator A5012148931 @default.
- W4309337510 creator A5058979654 @default.
- W4309337510 creator A5063405976 @default.
- W4309337510 creator A5066405485 @default.
- W4309337510 creator A5070749863 @default.
- W4309337510 creator A5087502360 @default.
- W4309337510 date "2023-01-01" @default.
- W4309337510 modified "2023-10-15" @default.
- W4309337510 title "BlpC-mediated selfish program leads to rapid loss of Streptococcus pneumoniae clonal diversity during infection" @default.
- W4309337510 cites W1516094891 @default.
- W4309337510 cites W1607222759 @default.
- W4309337510 cites W1974945063 @default.
- W4309337510 cites W1995913230 @default.
- W4309337510 cites W2002020281 @default.
- W4309337510 cites W2024333774 @default.
- W4309337510 cites W2050722710 @default.
- W4309337510 cites W2059125992 @default.
- W4309337510 cites W2067392831 @default.
- W4309337510 cites W2070627443 @default.
- W4309337510 cites W2076893605 @default.
- W4309337510 cites W2093371731 @default.
- W4309337510 cites W2099487698 @default.
- W4309337510 cites W2109107623 @default.
- W4309337510 cites W2118878242 @default.
- W4309337510 cites W2128721558 @default.
- W4309337510 cites W2131271579 @default.
- W4309337510 cites W2133454819 @default.
- W4309337510 cites W2144405999 @default.
- W4309337510 cites W2153125716 @default.
- W4309337510 cites W2171783890 @default.
- W4309337510 cites W2271711638 @default.
- W4309337510 cites W2302276367 @default.
- W4309337510 cites W2435927511 @default.
- W4309337510 cites W2460850757 @default.
- W4309337510 cites W2472193370 @default.
- W4309337510 cites W2531115075 @default.
- W4309337510 cites W2577533595 @default.
- W4309337510 cites W2591806215 @default.
- W4309337510 cites W2613567896 @default.
- W4309337510 cites W2794519236 @default.
- W4309337510 cites W2885998850 @default.
- W4309337510 cites W2898805761 @default.
- W4309337510 cites W2902586369 @default.
- W4309337510 cites W2946506169 @default.
- W4309337510 cites W2949236085 @default.
- W4309337510 cites W2950299756 @default.
- W4309337510 cites W2953151969 @default.
- W4309337510 cites W2953173473 @default.
- W4309337510 cites W3003850388 @default.
- W4309337510 cites W3006915344 @default.
- W4309337510 cites W3041303746 @default.
- W4309337510 cites W3081460337 @default.
- W4309337510 cites W3096626740 @default.
- W4309337510 cites W3111835585 @default.
- W4309337510 cites W3129463317 @default.
- W4309337510 cites W3135166865 @default.
- W4309337510 cites W3136217717 @default.
- W4309337510 cites W3144552257 @default.
- W4309337510 cites W3150704740 @default.
- W4309337510 cites W3165492495 @default.
- W4309337510 cites W3169485109 @default.
- W4309337510 cites W3192380610 @default.
- W4309337510 cites W3195582596 @default.
- W4309337510 cites W3198643625 @default.
- W4309337510 cites W3207156112 @default.
- W4309337510 cites W4221006369 @default.
- W4309337510 cites W4304084232 @default.
- W4309337510 cites W856245746 @default.
- W4309337510 doi "https://doi.org/10.1016/j.chom.2022.10.015" @default.
- W4309337510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36395758" @default.
- W4309337510 hasPublicationYear "2023" @default.
- W4309337510 type Work @default.
- W4309337510 citedByCount "2" @default.
- W4309337510 countsByYear W43093375102023 @default.
- W4309337510 crossrefType "journal-article" @default.
- W4309337510 hasAuthorship W4309337510A5012148931 @default.
- W4309337510 hasAuthorship W4309337510A5058979654 @default.
- W4309337510 hasAuthorship W4309337510A5063405976 @default.
- W4309337510 hasAuthorship W4309337510A5066405485 @default.
- W4309337510 hasAuthorship W4309337510A5070749863 @default.
- W4309337510 hasAuthorship W4309337510A5087502360 @default.
- W4309337510 hasBestOaLocation W43093375102 @default.
- W4309337510 hasConcept C104317684 @default.
- W4309337510 hasConcept C144024400 @default.
- W4309337510 hasConcept C149923435 @default.
- W4309337510 hasConcept C2776927270 @default.
- W4309337510 hasConcept C2781253189 @default.
- W4309337510 hasConcept C2908647359 @default.
- W4309337510 hasConcept C523546767 @default.
- W4309337510 hasConcept C54355233 @default.
- W4309337510 hasConcept C78458016 @default.
- W4309337510 hasConcept C81977670 @default.
- W4309337510 hasConcept C84597430 @default.
- W4309337510 hasConcept C86803240 @default.
- W4309337510 hasConcept C8891405 @default.
- W4309337510 hasConcept C89423630 @default.