Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309355564> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4309355564 endingPage "425" @default.
- W4309355564 startingPage "407" @default.
- W4309355564 abstract "The inhibition of the metabolism of one drug by another drug taken concurrently by the patient has now been shown to be a very important cause of adverse drug reactions (ADRs). In addition to the potential for drug–drug interactions leading to ADRs, the pharmaceutical industry is also very interested in enzyme inhibition as a basis for developing drugs that target specific enzymes of interest. This chapter focuses on approaches used to investigate the inhibition of the drug-metabolizing enzymes. Competitive inhibition occurs when the inhibitor binds reversibly to the enzyme and prevents the binding of the substrate to the catalytically active site of the enzyme. Transition-state analogs resemble the transition-state for the enzymatic reaction catalyzed by the enzyme. That is to say, they resemble the transient complex formed within the catalytic cycle that has the maximum free energy." @default.
- W4309355564 created "2022-11-26" @default.
- W4309355564 creator A5025474639 @default.
- W4309355564 date "2022-11-18" @default.
- W4309355564 modified "2023-10-16" @default.
- W4309355564 title "Enzyme Inhibition" @default.
- W4309355564 cites W1741338572 @default.
- W4309355564 cites W1923129209 @default.
- W4309355564 cites W2000790287 @default.
- W4309355564 cites W2003237988 @default.
- W4309355564 cites W2004136340 @default.
- W4309355564 cites W2016359652 @default.
- W4309355564 cites W2018964226 @default.
- W4309355564 cites W2043014652 @default.
- W4309355564 cites W2047006817 @default.
- W4309355564 cites W2056282083 @default.
- W4309355564 cites W2065261129 @default.
- W4309355564 cites W2072036446 @default.
- W4309355564 cites W2074648749 @default.
- W4309355564 cites W2098093433 @default.
- W4309355564 cites W2099242535 @default.
- W4309355564 cites W2133270655 @default.
- W4309355564 cites W2140484175 @default.
- W4309355564 cites W2169838870 @default.
- W4309355564 cites W2494562948 @default.
- W4309355564 doi "https://doi.org/10.1002/9781119851042.ch13" @default.
- W4309355564 hasPublicationYear "2022" @default.
- W4309355564 type Work @default.
- W4309355564 citedByCount "0" @default.
- W4309355564 crossrefType "other" @default.
- W4309355564 hasAuthorship W4309355564A5025474639 @default.
- W4309355564 hasConcept C107824862 @default.
- W4309355564 hasConcept C13053905 @default.
- W4309355564 hasConcept C150757390 @default.
- W4309355564 hasConcept C161790260 @default.
- W4309355564 hasConcept C181199279 @default.
- W4309355564 hasConcept C185592680 @default.
- W4309355564 hasConcept C18903297 @default.
- W4309355564 hasConcept C21951064 @default.
- W4309355564 hasConcept C2777289219 @default.
- W4309355564 hasConcept C2779715943 @default.
- W4309355564 hasConcept C2780035454 @default.
- W4309355564 hasConcept C41183919 @default.
- W4309355564 hasConcept C55493867 @default.
- W4309355564 hasConcept C71240020 @default.
- W4309355564 hasConcept C86803240 @default.
- W4309355564 hasConcept C89311334 @default.
- W4309355564 hasConcept C98274493 @default.
- W4309355564 hasConceptScore W4309355564C107824862 @default.
- W4309355564 hasConceptScore W4309355564C13053905 @default.
- W4309355564 hasConceptScore W4309355564C150757390 @default.
- W4309355564 hasConceptScore W4309355564C161790260 @default.
- W4309355564 hasConceptScore W4309355564C181199279 @default.
- W4309355564 hasConceptScore W4309355564C185592680 @default.
- W4309355564 hasConceptScore W4309355564C18903297 @default.
- W4309355564 hasConceptScore W4309355564C21951064 @default.
- W4309355564 hasConceptScore W4309355564C2777289219 @default.
- W4309355564 hasConceptScore W4309355564C2779715943 @default.
- W4309355564 hasConceptScore W4309355564C2780035454 @default.
- W4309355564 hasConceptScore W4309355564C41183919 @default.
- W4309355564 hasConceptScore W4309355564C55493867 @default.
- W4309355564 hasConceptScore W4309355564C71240020 @default.
- W4309355564 hasConceptScore W4309355564C86803240 @default.
- W4309355564 hasConceptScore W4309355564C89311334 @default.
- W4309355564 hasConceptScore W4309355564C98274493 @default.
- W4309355564 hasLocation W43093555641 @default.
- W4309355564 hasOpenAccess W4309355564 @default.
- W4309355564 hasPrimaryLocation W43093555641 @default.
- W4309355564 hasRelatedWork W1739571172 @default.
- W4309355564 hasRelatedWork W2008330105 @default.
- W4309355564 hasRelatedWork W2054560156 @default.
- W4309355564 hasRelatedWork W2070225836 @default.
- W4309355564 hasRelatedWork W2094016387 @default.
- W4309355564 hasRelatedWork W211573666 @default.
- W4309355564 hasRelatedWork W2415013382 @default.
- W4309355564 hasRelatedWork W2783771640 @default.
- W4309355564 hasRelatedWork W4256225328 @default.
- W4309355564 hasRelatedWork W4309355564 @default.
- W4309355564 isParatext "false" @default.
- W4309355564 isRetracted "false" @default.
- W4309355564 workType "other" @default.