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- W4309355802 endingPage "966" @default.
- W4309355802 startingPage "923" @default.
- W4309355802 abstract "Cancer is associated with alterations in numerous biochemical pathways including those involved in metabolism of drugs and other xenobiotics. This chapter will discuss patterns of changes in drug metabolism pathways in cancer, with particular emphasis of anticancer drugs. Drug resistance is one of the most challenging and poorly understood aspects of cancer biology. In this context, it will highlight how changes in endogenous metabolic machinery do or may potentially affect drug metabolism contributing to drug resistance. It will discuss metabolic reprogramming-dependent post-translational and epigenetic changes affecting drug metabolism that may be targeted for therapy in difficult-to-treat cancers. It will also discuss how exposure to anticancer drug themselves might trigger resistance to chemotherapy. In addition, it will highlight the emerging role of the microenvironment and cancer microbiome that may alter drug metabolism in cancer via endogenous metabolic reprogramming." @default.
- W4309355802 created "2022-11-26" @default.
- W4309355802 creator A5014031155 @default.
- W4309355802 creator A5048450819 @default.
- W4309355802 date "2022-11-18" @default.
- W4309355802 modified "2023-10-16" @default.
- W4309355802 title "Rewiring of Drug Metabolism and Its Cross‐talk with Metabolic Reprogramming in Cancer" @default.
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