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- W4309355879 endingPage "743" @default.
- W4309355879 startingPage "703" @default.
- W4309355879 abstract "This chapter deals with the mechanisms involved in the biotransformation of drugs to chemically reactive metabolites, the current experimental techniques used to identify reactive metabolites, and the potential consequences of reactive metabolite formation as it relates to the discovery of nontoxic drugs. Glutathione reacts with, and thereby captures, electrophilic metabolites by both nucleophilic substitution and nucleophilic addition reactions. If covalent binding to protein is detected, then the goal is to block exposure to the reactive intermediates by making strategic changes to the chemical structure of the candidate molecule to hinder bioactivation pathway. Naphthalene is an aromatic hydrocarbon that is made up of two fused benzene rings and can be found in cigarette smoke, petroleum-based fuels, and in mothballs. Pharmaceutical scientists working in drug metabolism and toxicology today consider reactive metabolites of drugs or drug candidates as an important potential toxicological issue." @default.
- W4309355879 created "2022-11-26" @default.
- W4309355879 creator A5062413533 @default.
- W4309355879 date "2022-11-18" @default.
- W4309355879 modified "2023-10-16" @default.
- W4309355879 title "Chemical Mechanisms in Toxicology" @default.
- W4309355879 cites W120815510 @default.
- W4309355879 cites W1257197030 @default.
- W4309355879 cites W1482264334 @default.
- W4309355879 cites W151164801 @default.
- W4309355879 cites W160522190 @default.
- W4309355879 cites W1797956629 @default.
- W4309355879 cites W1963563358 @default.
- W4309355879 cites W1967313237 @default.
- W4309355879 cites W1967684747 @default.
- W4309355879 cites W1968584338 @default.
- W4309355879 cites W1968687693 @default.
- W4309355879 cites W1969653690 @default.
- W4309355879 cites W1969866655 @default.
- W4309355879 cites W1972158464 @default.
- W4309355879 cites W1972948154 @default.
- W4309355879 cites W1973426823 @default.
- W4309355879 cites W1974541930 @default.
- W4309355879 cites W1974648730 @default.
- W4309355879 cites W1975338446 @default.
- W4309355879 cites W1975808862 @default.
- W4309355879 cites W1975970553 @default.
- W4309355879 cites W1976411764 @default.
- W4309355879 cites W1976660501 @default.
- W4309355879 cites W1979233147 @default.
- W4309355879 cites W1981171091 @default.
- W4309355879 cites W1982194814 @default.
- W4309355879 cites W1986617824 @default.
- W4309355879 cites W1989300686 @default.
- W4309355879 cites W1989908249 @default.
- W4309355879 cites W1990355599 @default.
- W4309355879 cites W1997144164 @default.
- W4309355879 cites W1999627552 @default.
- W4309355879 cites W1999763694 @default.
- W4309355879 cites W2000066924 @default.
- W4309355879 cites W2002378649 @default.
- W4309355879 cites W2002760011 @default.
- W4309355879 cites W2003181581 @default.
- W4309355879 cites W2003867270 @default.
- W4309355879 cites W2006311748 @default.
- W4309355879 cites W2008462293 @default.
- W4309355879 cites W2009911964 @default.
- W4309355879 cites W2010326342 @default.
- W4309355879 cites W2011017666 @default.
- W4309355879 cites W2012359191 @default.
- W4309355879 cites W2014239314 @default.
- W4309355879 cites W2015006039 @default.
- W4309355879 cites W2016218258 @default.
- W4309355879 cites W2017060911 @default.
- W4309355879 cites W2017783406 @default.
- W4309355879 cites W2018123263 @default.
- W4309355879 cites W2018276360 @default.
- W4309355879 cites W2022867019 @default.
- W4309355879 cites W2025152270 @default.
- W4309355879 cites W2025401031 @default.
- W4309355879 cites W2025645149 @default.
- W4309355879 cites W2028835780 @default.
- W4309355879 cites W2028908020 @default.
- W4309355879 cites W2031027489 @default.
- W4309355879 cites W2032071351 @default.
- W4309355879 cites W2033935070 @default.
- W4309355879 cites W2034224169 @default.
- W4309355879 cites W2034581891 @default.
- W4309355879 cites W2034804202 @default.
- W4309355879 cites W2036752080 @default.
- W4309355879 cites W2037691927 @default.
- W4309355879 cites W2040757966 @default.
- W4309355879 cites W2042436801 @default.
- W4309355879 cites W2043419877 @default.
- W4309355879 cites W2045786384 @default.
- W4309355879 cites W2046387493 @default.
- W4309355879 cites W2047467074 @default.
- W4309355879 cites W2050019973 @default.
- W4309355879 cites W2050347913 @default.
- W4309355879 cites W2056277100 @default.
- W4309355879 cites W2060245731 @default.
- W4309355879 cites W2061374166 @default.
- W4309355879 cites W2062934575 @default.
- W4309355879 cites W2063530433 @default.
- W4309355879 cites W2063611213 @default.
- W4309355879 cites W2063855838 @default.
- W4309355879 cites W2064395979 @default.
- W4309355879 cites W2065314861 @default.
- W4309355879 cites W2066029434 @default.
- W4309355879 cites W2066664962 @default.
- W4309355879 cites W2067559257 @default.
- W4309355879 cites W2067816697 @default.
- W4309355879 cites W2068420451 @default.
- W4309355879 cites W2068532562 @default.
- W4309355879 cites W2072489662 @default.
- W4309355879 cites W2073141598 @default.
- W4309355879 cites W2073224154 @default.
- W4309355879 cites W2074753679 @default.