FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309357466> ?p ?o ?g. }

• W4309357466 abstract "Abstract Pinostrobin was used in traditional medication for management of numerous syndromes. In the current study, histology, immunohistochemistry, and hepatoprotection effects of Pinostrobin were assessed against thioacetamide (TAA) hepatotoxicity in rats. Thirty rats were arbitrarily separated into five groups. Group 1 was intraperitoneally (i.p) injected with distilled water 3 times/week and fed (po) daily with 10% Tween 20 for 2 months. Group 2–5 were i.p. injected with 200 mg/kg TAA thrice weekly for 8 weeks and fed with 10% Tween 20, 50 mg/kg silymarin, 30 and 60 mg/kg of Pinostrobin daily for 8 weeks, respectively. Experimental groups fed groups showed that Pinostrobin significant reduction in liver index and hepatocyte proliferation with much lesser cell injury. These groups were significantly down-regulated the PCNA and α-SMA. The liver homogenate exhibited increased antioxidant enzymes (SOD and CAT) activities accompanied with decline in malondialdehyde (MDA) level. The serum level of bilirubin, total protein, albumin and liver enzymes (ALP, ALT, and AST) were restored to normal and were comparable to that normal control and silymarin with TAA treated groups. The hepatotoxic group showed a significant rise in serum liver biochemical markers together with a considerable decrease in protein and albumin level compared to the normal group. The hepatotoxic group displayed decreased catalase and superoxide dismutase activities while increased lipid peroxidation. Pinostrobin decreased level of TNF-a, IL-6 and increased the level of IL-10. Acute toxicity with a higher dose of 500 mg/kg Pinostrobin did not manifest any toxicological signs in rats. Macroscopy of hepatotoxic liver exhibited irregular, rough surface with micro and macro nodule. Histopathology stained by Hematoxylin and Eosin, and Masson Trichrome showed there was inflammation and infiltration of lymphocytes, focal necrosis, fibrosis, and bile duct propagation. Pinostrobin fed group had expressively reduced TAA toxicity in gross and histology as designated by fewer disturbances of hepatic tissue, slight fibrosis, and low-grade cells infiltration. Immunohistochemical staining designated that pinostrobin significantly down-regulated the expression of proliferation cellular nucleus antigen (PCNA) and alpha-smooth muscle actin (α-SMA) in the liver. Thus, the findings of this study presented that the hepatoprotective effect of this plant may be due to a reduction in toxicity, inhibition of hepatocytes proliferation, down-regulation of PCNA and α-SMA, decreased enzyme markersand increased protein and albumin increased endogenous enzymes and reduced lipid peroxidation level." @default.
• W4309357466 created "2022-11-26" @default.
• W4309357466 creator A5052046197 @default.
• W4309357466 creator A5069516883 @default.
• W4309357466 date "2022-11-18" @default.
• W4309357466 modified "2023-10-18" @default.
• W4309357466 title "Hepatoprotective effect of Pinostrobin against Thioacetamide-induced liver cirrhosis in rats" @default.
• W4309357466 cites W1878051894 @default.
• W4309357466 cites W1905331525 @default.
• W4309357466 cites W2034931122 @default.
• W4309357466 cites W2058028443 @default.
• W4309357466 cites W2059348329 @default.
• W4309357466 cites W2109606842 @default.
• W4309357466 cites W2113200312 @default.
• W4309357466 cites W2139646168 @default.
• W4309357466 cites W2170757694 @default.
• W4309357466 cites W2218060788 @default.
• W4309357466 cites W2731568532 @default.
• W4309357466 cites W2750515859 @default.
• W4309357466 cites W2767586242 @default.
• W4309357466 cites W2774822425 @default.
• W4309357466 cites W2779319743 @default.
• W4309357466 cites W2793652126 @default.
• W4309357466 cites W2799799854 @default.
• W4309357466 cites W2884534635 @default.
• W4309357466 cites W2885602654 @default.
• W4309357466 cites W2901161495 @default.
• W4309357466 cites W2917599433 @default.
• W4309357466 cites W2922859673 @default.
• W4309357466 cites W2939723392 @default.
• W4309357466 cites W2947034929 @default.
• W4309357466 cites W2948423131 @default.
• W4309357466 cites W2957403569 @default.
• W4309357466 cites W2973961961 @default.
• W4309357466 cites W2977634348 @default.
• W4309357466 cites W2980361925 @default.
• W4309357466 cites W3005192023 @default.
• W4309357466 cites W3006488526 @default.
• W4309357466 cites W3024682573 @default.
• W4309357466 cites W3024746883 @default.
• W4309357466 cites W3026026074 @default.
• W4309357466 cites W3029954845 @default.
• W4309357466 cites W3036013765 @default.
• W4309357466 cites W3044631602 @default.
• W4309357466 cites W3045084498 @default.
• W4309357466 cites W3045714113 @default.
• W4309357466 cites W3080411788 @default.
• W4309357466 cites W3087311799 @default.
• W4309357466 cites W3107366842 @default.
• W4309357466 cites W3116406719 @default.
• W4309357466 cites W3120547932 @default.
• W4309357466 cites W3120568349 @default.
• W4309357466 cites W3127217171 @default.
• W4309357466 cites W3158660933 @default.
• W4309357466 cites W3193863364 @default.
• W4309357466 cites W3208330042 @default.
• W4309357466 cites W636564282 @default.
• W4309357466 doi "https://doi.org/10.21203/rs.3.rs-2287228/v1" @default.
• W4309357466 hasPublicationYear "2022" @default.
• W4309357466 type Work @default.
• W4309357466 citedByCount "0" @default.
• W4309357466 crossrefType "posted-content" @default.
• W4309357466 hasAuthorship W4309357466A5052046197 @default.
• W4309357466 hasAuthorship W4309357466A5069516883 @default.
• W4309357466 hasBestOaLocation W43093574661 @default.
• W4309357466 hasConcept C126322002 @default.
• W4309357466 hasConcept C178790620 @default.
• W4309357466 hasConcept C181199279 @default.
• W4309357466 hasConcept C185592680 @default.
• W4309357466 hasConcept C202751555 @default.
• W4309357466 hasConcept C2775838275 @default.
• W4309357466 hasConcept C2776125364 @default.
• W4309357466 hasConcept C2776200302 @default.
• W4309357466 hasConcept C2776514860 @default.
• W4309357466 hasConcept C2776637226 @default.
• W4309357466 hasConcept C2777214474 @default.
• W4309357466 hasConcept C2777359374 @default.
• W4309357466 hasConcept C2777513400 @default.
• W4309357466 hasConcept C2778004101 @default.
• W4309357466 hasConcept C2778401633 @default.
• W4309357466 hasConcept C2778979269 @default.
• W4309357466 hasConcept C2780829032 @default.
• W4309357466 hasConcept C2781057625 @default.
• W4309357466 hasConcept C538909803 @default.
• W4309357466 hasConcept C55493867 @default.
• W4309357466 hasConcept C71924100 @default.
• W4309357466 hasConcept C98274493 @default.
• W4309357466 hasConceptScore W4309357466C126322002 @default.
• W4309357466 hasConceptScore W4309357466C178790620 @default.
• W4309357466 hasConceptScore W4309357466C181199279 @default.
• W4309357466 hasConceptScore W4309357466C185592680 @default.
• W4309357466 hasConceptScore W4309357466C202751555 @default.
• W4309357466 hasConceptScore W4309357466C2775838275 @default.
• W4309357466 hasConceptScore W4309357466C2776125364 @default.
• W4309357466 hasConceptScore W4309357466C2776200302 @default.
• W4309357466 hasConceptScore W4309357466C2776514860 @default.
• W4309357466 hasConceptScore W4309357466C2776637226 @default.
• W4309357466 hasConceptScore W4309357466C2777214474 @default.
• W4309357466 hasConceptScore W4309357466C2777359374 @default.
• W4309357466 hasConceptScore W4309357466C2777513400 @default.

• next