FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309367195> ?p ?o ?g. }

• W4309367195 endingPage "6444" @default.
• W4309367195 startingPage "6437" @default.
• W4309367195 abstract "Abstract Background Risk stratification of kidney cancer patients after nephrectomy may tailor surveillance intensity and selection for adjuvant therapy. Transcriptomic approaches are effective in predicting recurrence, but whether they add value to clinicopathologic models remains unclear. Methods Data from patients with clear cell renal cell carcinoma (ccRCC) was downloaded from The Cancer Genome Atlas. Clinicopathologic variables were used to calculate SSIGN (stage, size, grade, and necrosis) scores. The 16 gene recurrence score (RS) signature was generated using RNA‐seq data. Transcriptomic risk groups were calculated using the original thresholds. SSIGN groups were divided into low, intermediate, and high risk. Disease‐free status was the primary endpoint assessed. Results SSIGN and RS were calculated for 428 patients with non‐metastatic ccRCC. SSIGN low‐, intermediate‐, and high‐risk groups demonstrated 2.7%, 15.2%, and 27.5%, 3‐year recurrence risk, respectively. On multivariable analysis, the RS was associated with disease‐free status (sub‐distribution hazard ratio (sHR) 1.43 per 25 RS [95% CI (1.00–1.43)], p = 0.05). By risk groups, RS further risk stratified the SSIGN intermediate‐risk group (sHR 2.22 [95% CI 1.10–4.50], p = 0.03). SSIGN intermediate‐risk patients with low and high RS had a 3‐year recurrence rate of 8.0% and 25.2%, respectively. Within this risk group, the area under the curve (AUC) at 3 years was 0.69 for SSIGN, 0.74 for RS, and 0.78 for their combination. Conclusions Transcriptomic recurrence scores improve risk prediction even when controlling for clinicopathologic factors. Utility may be best suited for intermediate‐risk patients who have heterogeneous outcomes and further refinement for clinical utility is warranted." @default.
• W4309367195 created "2022-11-26" @default.
• W4309367195 creator A5002263179 @default.
• W4309367195 creator A5014582211 @default.
• W4309367195 creator A5022014477 @default.
• W4309367195 creator A5023363049 @default.
• W4309367195 creator A5039495553 @default.
• W4309367195 creator A5047592790 @default.
• W4309367195 creator A5050405997 @default.
• W4309367195 creator A5052069448 @default.
• W4309367195 creator A5054385545 @default.
• W4309367195 creator A5070111340 @default.
• W4309367195 creator A5075078834 @default.
• W4309367195 creator A5084023452 @default.
• W4309367195 creator A5084448971 @default.
• W4309367195 date "2022-11-17" @default.
• W4309367195 modified "2023-09-26" @default.
• W4309367195 title "Transcriptomic recurrence score improves recurrence prediction for surgically treated patients with intermediate‐risk clear cell kidney cancer" @default.
• W4309367195 cites W1509042831 @default.
• W4309367195 cites W1896930635 @default.
• W4309367195 cites W2038981426 @default.
• W4309367195 cites W2121827874 @default.
• W4309367195 cites W2137970869 @default.
• W4309367195 cites W2148497849 @default.
• W4309367195 cites W2150095882 @default.
• W4309367195 cites W2172045238 @default.
• W4309367195 cites W2293077587 @default.
• W4309367195 cites W2415160055 @default.
• W4309367195 cites W2475362987 @default.
• W4309367195 cites W2530419161 @default.
• W4309367195 cites W2601335591 @default.
• W4309367195 cites W2797542577 @default.
• W4309367195 cites W2805302875 @default.
• W4309367195 cites W2949246094 @default.
• W4309367195 cites W3010196076 @default.
• W4309367195 cites W3087071175 @default.
• W4309367195 cites W3087696731 @default.
• W4309367195 cites W3096713247 @default.
• W4309367195 cites W3119567495 @default.
• W4309367195 cites W3171353445 @default.
• W4309367195 cites W3196207248 @default.
• W4309367195 cites W4205710681 @default.
• W4309367195 cites W4309367195 @default.
• W4309367195 doi "https://doi.org/10.1002/cam4.5399" @default.
• W4309367195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36397716" @default.
• W4309367195 hasPublicationYear "2022" @default.
• W4309367195 type Work @default.
• W4309367195 citedByCount "1" @default.
• W4309367195 countsByYear W43093671952022 @default.
• W4309367195 crossrefType "journal-article" @default.
• W4309367195 hasAuthorship W4309367195A5002263179 @default.
• W4309367195 hasAuthorship W4309367195A5014582211 @default.
• W4309367195 hasAuthorship W4309367195A5022014477 @default.
• W4309367195 hasAuthorship W4309367195A5023363049 @default.
• W4309367195 hasAuthorship W4309367195A5039495553 @default.
• W4309367195 hasAuthorship W4309367195A5047592790 @default.
• W4309367195 hasAuthorship W4309367195A5050405997 @default.
• W4309367195 hasAuthorship W4309367195A5052069448 @default.
• W4309367195 hasAuthorship W4309367195A5054385545 @default.
• W4309367195 hasAuthorship W4309367195A5070111340 @default.
• W4309367195 hasAuthorship W4309367195A5075078834 @default.
• W4309367195 hasAuthorship W4309367195A5084023452 @default.
• W4309367195 hasAuthorship W4309367195A5084448971 @default.
• W4309367195 hasBestOaLocation W43093671951 @default.
• W4309367195 hasConcept C11783203 @default.
• W4309367195 hasConcept C121608353 @default.
• W4309367195 hasConcept C126322002 @default.
• W4309367195 hasConcept C143998085 @default.
• W4309367195 hasConcept C203092338 @default.
• W4309367195 hasConcept C207103383 @default.
• W4309367195 hasConcept C2777472916 @default.
• W4309367195 hasConcept C2777982462 @default.
• W4309367195 hasConcept C2779134260 @default.
• W4309367195 hasConcept C2780091579 @default.
• W4309367195 hasConcept C2780227381 @default.
• W4309367195 hasConcept C2781068499 @default.
• W4309367195 hasConcept C2781278892 @default.
• W4309367195 hasConcept C3020404979 @default.
• W4309367195 hasConcept C34626388 @default.
• W4309367195 hasConcept C44249647 @default.
• W4309367195 hasConcept C50382708 @default.
• W4309367195 hasConcept C535046627 @default.
• W4309367195 hasConcept C71924100 @default.
• W4309367195 hasConcept C90924648 @default.
• W4309367195 hasConceptScore W4309367195C11783203 @default.
• W4309367195 hasConceptScore W4309367195C121608353 @default.
• W4309367195 hasConceptScore W4309367195C126322002 @default.
• W4309367195 hasConceptScore W4309367195C143998085 @default.
• W4309367195 hasConceptScore W4309367195C203092338 @default.
• W4309367195 hasConceptScore W4309367195C207103383 @default.
• W4309367195 hasConceptScore W4309367195C2777472916 @default.
• W4309367195 hasConceptScore W4309367195C2777982462 @default.
• W4309367195 hasConceptScore W4309367195C2779134260 @default.
• W4309367195 hasConceptScore W4309367195C2780091579 @default.
• W4309367195 hasConceptScore W4309367195C2780227381 @default.
• W4309367195 hasConceptScore W4309367195C2781068499 @default.
• W4309367195 hasConceptScore W4309367195C2781278892 @default.
• W4309367195 hasConceptScore W4309367195C3020404979 @default.

• next