Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309372298> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4309372298 abstract "Background: Clinical trials evaluating immune checkpoint inhibition (ICI) in recurrent high-grade gliomas (rHGG) report 7-20% 6-month progression-free survival (PFS), while re-irradiation demonstrates 28%-39% 6-month PFS. Aims: We evaluate outcomes of patients treated with ICI and concurrent re-irradiation utilizing stereotactic body radiotherapy / fractionated stereotactic radiosurgery (SBRT) compared to ICI monotherapy. Methods and Results: Patients >18-years-old with rHGG (WHO grade III and IV) receiving ICI+SBRT or ICI monotherapy between 1/1/16-1/1/19 were included. Adverse events, 6-month PFS and overall survival (OS) were assessed. Log-rank tests were used to evaluate PFS and OS. Histogram analyses of apparent diffusion coefficient maps and dynamic contrast-enhanced magnetic resonance perfusion metrics were performed. Twenty-one patients with rHGG (ICI+SBRT: 16; ICI: 5) were included. The ICI+SBRT and ICI groups received a mean 7.25 and 6.2 ICI cycles, respectively. There were five grade 1, one grade 2 and no grade 3-5 AEs in the ICI+SBRT group, and four grade 1 and no grade 2-5 AEs in the ICI group. Median PFS was 2.85 and 1 month for the ICI+SBRT and ICI groups; median OS was 7 and 6 months among ICI+SBRT and ICI groups, respectively. There were significant differences in pre- and post-treatment tumor volume in the cohort (12.35 vs. 20.51; p=0.03), but not between treatment groups. Conclusions: In this heavily pretreated cohort, ICI with re-irradiation utilizing SBRT was well tolerated. Prospective studies are warranted to evaluate potential therapeutic benefits to re-irradiation with ICI+SBRT in rHGG." @default.
- W4309372298 created "2022-11-26" @default.
- W4309372298 creator A5010278889 @default.
- W4309372298 creator A5011021052 @default.
- W4309372298 creator A5016683007 @default.
- W4309372298 creator A5019249199 @default.
- W4309372298 creator A5026845864 @default.
- W4309372298 creator A5027650800 @default.
- W4309372298 creator A5030507987 @default.
- W4309372298 creator A5037483760 @default.
- W4309372298 creator A5042073241 @default.
- W4309372298 creator A5045925835 @default.
- W4309372298 creator A5080490911 @default.
- W4309372298 creator A5083839627 @default.
- W4309372298 date "2022-11-18" @default.
- W4309372298 modified "2023-10-03" @default.
- W4309372298 title "Concurrent immunotherapy and re-irradiation utilizing stereotactic body radiotherapy for recurrent high-grade gliomas" @default.
- W4309372298 doi "https://doi.org/10.22541/au.166879032.24261533/v1" @default.
- W4309372298 hasPublicationYear "2022" @default.
- W4309372298 type Work @default.
- W4309372298 citedByCount "0" @default.
- W4309372298 crossrefType "posted-content" @default.
- W4309372298 hasAuthorship W4309372298A5010278889 @default.
- W4309372298 hasAuthorship W4309372298A5011021052 @default.
- W4309372298 hasAuthorship W4309372298A5016683007 @default.
- W4309372298 hasAuthorship W4309372298A5019249199 @default.
- W4309372298 hasAuthorship W4309372298A5026845864 @default.
- W4309372298 hasAuthorship W4309372298A5027650800 @default.
- W4309372298 hasAuthorship W4309372298A5030507987 @default.
- W4309372298 hasAuthorship W4309372298A5037483760 @default.
- W4309372298 hasAuthorship W4309372298A5042073241 @default.
- W4309372298 hasAuthorship W4309372298A5045925835 @default.
- W4309372298 hasAuthorship W4309372298A5080490911 @default.
- W4309372298 hasAuthorship W4309372298A5083839627 @default.
- W4309372298 hasBestOaLocation W43093722981 @default.
- W4309372298 hasConcept C126322002 @default.
- W4309372298 hasConcept C126838900 @default.
- W4309372298 hasConcept C126894567 @default.
- W4309372298 hasConcept C143409427 @default.
- W4309372298 hasConcept C143998085 @default.
- W4309372298 hasConcept C197934379 @default.
- W4309372298 hasConcept C2780387249 @default.
- W4309372298 hasConcept C2780739268 @default.
- W4309372298 hasConcept C2989005 @default.
- W4309372298 hasConcept C3019894029 @default.
- W4309372298 hasConcept C509974204 @default.
- W4309372298 hasConcept C71924100 @default.
- W4309372298 hasConcept C72563966 @default.
- W4309372298 hasConceptScore W4309372298C126322002 @default.
- W4309372298 hasConceptScore W4309372298C126838900 @default.
- W4309372298 hasConceptScore W4309372298C126894567 @default.
- W4309372298 hasConceptScore W4309372298C143409427 @default.
- W4309372298 hasConceptScore W4309372298C143998085 @default.
- W4309372298 hasConceptScore W4309372298C197934379 @default.
- W4309372298 hasConceptScore W4309372298C2780387249 @default.
- W4309372298 hasConceptScore W4309372298C2780739268 @default.
- W4309372298 hasConceptScore W4309372298C2989005 @default.
- W4309372298 hasConceptScore W4309372298C3019894029 @default.
- W4309372298 hasConceptScore W4309372298C509974204 @default.
- W4309372298 hasConceptScore W4309372298C71924100 @default.
- W4309372298 hasConceptScore W4309372298C72563966 @default.
- W4309372298 hasLocation W43093722981 @default.
- W4309372298 hasOpenAccess W4309372298 @default.
- W4309372298 hasPrimaryLocation W43093722981 @default.
- W4309372298 hasRelatedWork W1981053175 @default.
- W4309372298 hasRelatedWork W2039831062 @default.
- W4309372298 hasRelatedWork W2156028401 @default.
- W4309372298 hasRelatedWork W2401773868 @default.
- W4309372298 hasRelatedWork W2508468768 @default.
- W4309372298 hasRelatedWork W2633347142 @default.
- W4309372298 hasRelatedWork W2811223828 @default.
- W4309372298 hasRelatedWork W2971660207 @default.
- W4309372298 hasRelatedWork W4327920375 @default.
- W4309372298 hasRelatedWork W4362393418 @default.
- W4309372298 isParatext "false" @default.
- W4309372298 isRetracted "false" @default.
- W4309372298 workType "article" @default.