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- W4309376640 abstract "Human skin is submitted to hyperpigmentation disorders during our life: senile lentigo, linked to intrinsic ageing, leads to a loss of melanogenesis’ control while solar lentigo, linked to UV exposure, promotes an increase of oxidized proteins, melanogenesis and lipofuscin accumulation. SDF1 (Stromal cell-derived factor 1) was recently identified as key regulator of pigmentation via the inhibition of cAMP pathway in melanocytes. SDF1 expression is reduced in senescent fibroblasts during senile lentigo, pushing this protein as a strategic target for skin hyperpigmentation. We developed two skin explant models mimicking of senile and solar lentigo based on H2O2 systemic treatment and UV-irradiation respectively. We evaluated Himanthalia elongata extract (HEX) on these models after 5 days of treatment and analysed SDF1 expression and skin pigmentation. For solar lentigo, we also analysed oxidized proteins and lipofuscin accumulation. To finish, we evaluated HEX in vivo on nearly 100 multi ethnicities’ volunteers. Regarding senile lentigo model, SDF1 expression was decreased and associated to an hyperpigmentation. The application of HEX restored SDF1 expression, leading to a decrease of skin pigmentation. For solar lentigo, we showed for a very first time an impact of UVs on SDF1 expression. The inhibition of this key regulator led to an hyperpigmentation in the model while the application of HEX restored the expression of SDF1 and reduced the skin pigmentation. On this same model, HEX also reduced the amount of oxidized proteins and lipofuscin which were increased by UV-exposure. Regarding clinical evaluation, HEX reduced dark spots pigmentation on Caucasian volunteers’ hands and on Asian and African volunteers’ face after 28 days. To conclude, we developed ex vivo models mimetic of senile and solar lentigo and showed for a very first time that SDF1 can be also a key regulator for UV-induced hyperpigmentation. Clinical studies highlighted the power of HEX with strong reduction of dark spots regardless of the volunteers’ ethnicities." @default.
- W4309376640 created "2022-11-26" @default.
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- W4309376640 date "2022-12-01" @default.
- W4309376640 modified "2023-09-25" @default.
- W4309376640 title "523 Targeting SDF-1 as an efficient strategy to resolve skin hyperpigmentation issues with Himanthalia elongata extract" @default.
- W4309376640 doi "https://doi.org/10.1016/j.jid.2022.09.538" @default.
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