FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309380010> ?p ?o ?g. }

• W4309380010 abstract "This study aimed to evaluate the potential mechanism by which Monocyte locomotion inhibitory factor (MLIF) improves the outcome of ischemic stroke (IS) inflammatory injury.Potential MLIF-related targets were predicted using Swiss TargetPrediction and PharmMapper, while IS-related targets were found from GeneCards, PharmGKB, and Therapeutic Target Database (TTD). After obtaining the intersection from these two datasets, the Search Tool for Retrieval of Interacting Genes/Protein (STRING11.0) database was used to analyze the protein-protein interaction (PPI) network of the intersection and candidate genes for MLIF treatment of IS. The candidate genes were imported into the Metascape database for Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The top 20 core genes and the MLIF-target-pathway network were mapped using the Cytoscape3.9.1. Using AutoDock Vina1.1.2, the molecular docking validation of the hub targets and MLIF was carried out. In the experimental part, transient middle cerebral artery occlusion (tMCAO) and oxygen and glucose deprivation (OGD) models were used to evaluate the protective efficacy of MLIF and the expression of inflammatory cytokines and the putative targets.MLIF was expected to have an effect on 370 targets. When these targets were intersected with 1,289 targets for ischemic stroke, 119 candidate therapeutic targets were found. The key enriched pathways were PI3K-Akt signaling pathway and MAPK signaling pathway, etc. The GO analysis yielded 1,677 GO entries (P < 0.01), such as hormone stimulation, inflammatory response, etc. The top 20 core genes included AKT1, EGFR, IGF1, MAPK1, MAPK10, MAPK14, etc. The result of molecular docking demonstrated that MLIF had the strong binding capability to JNK (MAPK10). The in vitro and in vivo studies also confirmed that MLIF protected against IS by lowering JNK (MAPK10) and AP-1 levels and decreasing pro-inflammatory cytokines (IL-1, IL-6).MLIF may exert a cerebral protective effect by inhibiting the inflammatory response through suppressing the JNK/AP-1 signaling pathway." @default.
• W4309380010 created "2022-11-26" @default.
• W4309380010 creator A5003766363 @default.
• W4309380010 creator A5010391574 @default.
• W4309380010 creator A5025783562 @default.
• W4309380010 creator A5033210492 @default.
• W4309380010 creator A5055207211 @default.
• W4309380010 creator A5090732689 @default.
• W4309380010 creator A5091806398 @default.
• W4309380010 date "2022-11-18" @default.
• W4309380010 modified "2023-10-14" @default.
• W4309380010 title "Network pharmacology and molecular docking-based analysis of protective mechanism of MLIF in ischemic stroke" @default.
• W4309380010 cites W1483834122 @default.
• W4309380010 cites W1653739410 @default.
• W4309380010 cites W1906327883 @default.
• W4309380010 cites W1996423918 @default.
• W4309380010 cites W2000476522 @default.
• W4309380010 cites W2023222970 @default.
• W4309380010 cites W2077404136 @default.
• W4309380010 cites W2079031049 @default.
• W4309380010 cites W2085398335 @default.
• W4309380010 cites W2088193472 @default.
• W4309380010 cites W2101068306 @default.
• W4309380010 cites W2103912979 @default.
• W4309380010 cites W2112505121 @default.
• W4309380010 cites W2125914602 @default.
• W4309380010 cites W2127026664 @default.
• W4309380010 cites W2131599914 @default.
• W4309380010 cites W2143977833 @default.
• W4309380010 cites W2148455893 @default.
• W4309380010 cites W2159675211 @default.
• W4309380010 cites W2169678694 @default.
• W4309380010 cites W2278567865 @default.
• W4309380010 cites W2324841714 @default.
• W4309380010 cites W2474047672 @default.
• W4309380010 cites W2584555069 @default.
• W4309380010 cites W2590912172 @default.
• W4309380010 cites W2592474654 @default.
• W4309380010 cites W2611425558 @default.
• W4309380010 cites W2792355005 @default.
• W4309380010 cites W2792944991 @default.
• W4309380010 cites W2797300785 @default.
• W4309380010 cites W2808597917 @default.
• W4309380010 cites W2816160204 @default.
• W4309380010 cites W2883620619 @default.
• W4309380010 cites W2891142298 @default.
• W4309380010 cites W2917040899 @default.
• W4309380010 cites W2928665623 @default.
• W4309380010 cites W2950997460 @default.
• W4309380010 cites W2955473528 @default.
• W4309380010 cites W2971801381 @default.
• W4309380010 cites W2973523639 @default.
• W4309380010 cites W2987928072 @default.
• W4309380010 cites W2997160604 @default.
• W4309380010 cites W3005722875 @default.
• W4309380010 cites W3082281712 @default.
• W4309380010 cites W3090690281 @default.
• W4309380010 cites W3092849554 @default.
• W4309380010 cites W3093285665 @default.
• W4309380010 cites W3107527779 @default.
• W4309380010 cites W3110131096 @default.
• W4309380010 cites W3198461437 @default.
• W4309380010 cites W4200444653 @default.
• W4309380010 cites W4206382201 @default.
• W4309380010 cites W4243541841 @default.
• W4309380010 doi "https://doi.org/10.3389/fcvm.2022.1071533" @default.
• W4309380010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36465453" @default.
• W4309380010 hasPublicationYear "2022" @default.
• W4309380010 type Work @default.
• W4309380010 citedByCount "0" @default.
• W4309380010 crossrefType "journal-article" @default.
• W4309380010 hasAuthorship W4309380010A5003766363 @default.
• W4309380010 hasAuthorship W4309380010A5010391574 @default.
• W4309380010 hasAuthorship W4309380010A5025783562 @default.
• W4309380010 hasAuthorship W4309380010A5033210492 @default.
• W4309380010 hasAuthorship W4309380010A5055207211 @default.
• W4309380010 hasAuthorship W4309380010A5090732689 @default.
• W4309380010 hasAuthorship W4309380010A5091806398 @default.
• W4309380010 hasBestOaLocation W43093800101 @default.
• W4309380010 hasConcept C104317684 @default.
• W4309380010 hasConcept C150194340 @default.
• W4309380010 hasConcept C152724338 @default.
• W4309380010 hasConcept C162317418 @default.
• W4309380010 hasConcept C54355233 @default.
• W4309380010 hasConcept C60644358 @default.
• W4309380010 hasConcept C69991583 @default.
• W4309380010 hasConcept C70721500 @default.
• W4309380010 hasConcept C71924100 @default.
• W4309380010 hasConcept C86803240 @default.
• W4309380010 hasConcept C98274493 @default.
• W4309380010 hasConceptScore W4309380010C104317684 @default.
• W4309380010 hasConceptScore W4309380010C150194340 @default.
• W4309380010 hasConceptScore W4309380010C152724338 @default.
• W4309380010 hasConceptScore W4309380010C162317418 @default.
• W4309380010 hasConceptScore W4309380010C54355233 @default.
• W4309380010 hasConceptScore W4309380010C60644358 @default.
• W4309380010 hasConceptScore W4309380010C69991583 @default.
• W4309380010 hasConceptScore W4309380010C70721500 @default.
• W4309380010 hasConceptScore W4309380010C71924100 @default.
• W4309380010 hasConceptScore W4309380010C86803240 @default.

• next