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- W4309381489 abstract "Senescent cells contribute to the functional decline of the skin via the senescence-associated secretory phenotypes. The accumulation of senescent cells plays a role in the development of photoaging pigmentation and skin aging. We investigated age-dependent cellular senescence in in vivo skin. Seventy biopsied skins taken from 1 to 81 years old subjects were obtained. The samples were grouped from the age 0-20, 21-40, 41-60 and 61-81 and further classified into the ‘exposed’ and ‘unexposed’ group. p16INK4A, a most reliable marker of cellular senescence was assayed with immunohistochemical study. The number of p16INK4A positive fibroblasts, melanocytes, and keratinocytes was significantly increased with age. Fibroblasts were the major senescent cells observed in all age groups. Whereas, senescent melanocytes appeared after middle-age. Compared to unexposed skin, more senescent melanocytes and fibroblasts were observed in exposed skin. Especially, the increase of senescent melanocytes in the exposed skin was significant over 61 years old. The number of senescent melanocytes was significantly correlated with the number of keratinocytes and fibroblasts. Especially, the correlation between the senescent melanocytes and keratinocytes was still significant even when controlling for age. This study showed that senescent fibroblast in exposed skin precedes epidermal senescence and the parallel aging of melanocytes and keratinocytes/fibroblasts was noted. We conclude by highlighting the potential of senotherapeutics, specifically targeting senescent melanocytes in delaying the onset and propagation of age-associated phenotypes in the skin." @default.
- W4309381489 created "2022-11-26" @default.
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- W4309381489 date "2022-12-01" @default.
- W4309381489 modified "2023-09-25" @default.
- W4309381489 title "530 Age-dependent sequential increase of senescent cells in the skin" @default.
- W4309381489 doi "https://doi.org/10.1016/j.jid.2022.09.545" @default.
- W4309381489 hasPublicationYear "2022" @default.
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