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- W4309388529 abstract "Abstract Mitotic duration is tightly constrained, with extended mitotic duration being a characteristic of potentially problematic cells prone to chromosome missegregation and genomic instability. We show that memories of mitotic duration are integrated by a p53-based mitotic stopwatch pathway to exert tight control over proliferation. The stopwatch halts proliferation of the products of a single significantly extended mitosis or of successive modestly extended mitoses. Time in mitosis is monitored via mitotic kinase-regulated assembly of stopwatch complexes that are transmitted to daughter cells. The stopwatch is inactivated in p53-mutant cancers, as well as in a significant proportion of p53-wildtype cancers, consistent with classification of stopwatch complex subunits as tumor suppressors. Stopwatch status additionally influences efficacy of anti-mitotic agents currently used or in development for cancer therapy. One-Sentence Summary Time spent in mitosis is carefully monitored to halt the proliferation of potentially dangerous cells in a population." @default.
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- W4309388529 date "2022-11-16" @default.
- W4309388529 modified "2023-10-18" @default.
- W4309388529 title "Control of cell proliferation by memories of mitosis" @default.
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- W4309388529 doi "https://doi.org/10.1101/2022.11.14.515741" @default.
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