FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309388545> ?p ?o ?g. }

• W4309388545 abstract "Abstract Multiple myeloma (MM) is an osteolytic plasma cell malignancy that, despite being responsive to therapies such as proteasome inhibitors, frequently relapses. Understanding the mechanism and the niches where resistant disease evolves remains of major clinical importance. Cancer cell intrinsic mechanisms and bone ecosystem factors are known contributors to the evolution of resistant MM but the exact contribution of each is difficult to define with current in vitro and in vivo models. However, mathematical modeling can help address this gap in knowledge. Here, we describe a novel biology-driven hybrid agent-based model that incorporates key cellular species of the bone ecosystem that control normal bone remodeling and, in MM, yields a protective environment under therapy. Critically, the spatiotemporal nature of the model captures two key features: normal bone homeostasis and how MM interacts with the bone ecosystem to induce bone destruction. We next used the model to examine how the bone ecosystem contributes to the evolutionary dynamics of resistant MM under control and proteasome inhibitor treatment. Our data demonstrates that resistant disease cannot develop without MM intrinsic mechanisms. However, protection from the bone microenvironment dramatically increases the likelihood of developing intrinsic resistance and subsequent relapse. The spatial nature of the model also reveals how the bone ecosystem provides a protective niche for drug sensitive MM cells under treatment, consequently leading to the emergence of a heterogenous and drug resistant disease. In conclusion, our data demonstrates a significant role for the bone ecosystem in MM survival and resistance, and suggests that early intervention with bone ecosystem targeting therapies may prevent the emergence of heterogeneous drug resistant MM." @default.
• W4309388545 created "2022-11-26" @default.
• W4309388545 creator A5003774553 @default.
• W4309388545 creator A5005942374 @default.
• W4309388545 creator A5033187881 @default.
• W4309388545 creator A5045272550 @default.
• W4309388545 creator A5053572690 @default.
• W4309388545 creator A5074163739 @default.
• W4309388545 creator A5086326013 @default.
• W4309388545 date "2022-11-16" @default.
• W4309388545 modified "2023-10-14" @default.
• W4309388545 title "The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease" @default.
• W4309388545 cites W1559595371 @default.
• W4309388545 cites W1757602702 @default.
• W4309388545 cites W1885204825 @default.
• W4309388545 cites W1946820278 @default.
• W4309388545 cites W1965570423 @default.
• W4309388545 cites W1968628080 @default.
• W4309388545 cites W1972567449 @default.
• W4309388545 cites W1973849127 @default.
• W4309388545 cites W1977328011 @default.
• W4309388545 cites W1978239979 @default.
• W4309388545 cites W1984046567 @default.
• W4309388545 cites W1984437179 @default.
• W4309388545 cites W1996560056 @default.
• W4309388545 cites W1996962457 @default.
• W4309388545 cites W1998650056 @default.
• W4309388545 cites W2001301608 @default.
• W4309388545 cites W2001558395 @default.
• W4309388545 cites W2005794914 @default.
• W4309388545 cites W2007934094 @default.
• W4309388545 cites W2010552629 @default.
• W4309388545 cites W2012056552 @default.
• W4309388545 cites W2012582974 @default.
• W4309388545 cites W2013184426 @default.
• W4309388545 cites W2016009250 @default.
• W4309388545 cites W2022112190 @default.
• W4309388545 cites W2027363930 @default.
• W4309388545 cites W2031180692 @default.
• W4309388545 cites W2031692900 @default.
• W4309388545 cites W2043614433 @default.
• W4309388545 cites W2045484383 @default.
• W4309388545 cites W2048217074 @default.
• W4309388545 cites W2051517030 @default.
• W4309388545 cites W2051807618 @default.
• W4309388545 cites W2055298955 @default.
• W4309388545 cites W2055662838 @default.
• W4309388545 cites W2058555823 @default.
• W4309388545 cites W2060363283 @default.
• W4309388545 cites W2066616821 @default.
• W4309388545 cites W2067459417 @default.
• W4309388545 cites W2067680442 @default.
• W4309388545 cites W2069998730 @default.
• W4309388545 cites W2070547493 @default.
• W4309388545 cites W2072546530 @default.
• W4309388545 cites W2072958401 @default.
• W4309388545 cites W2075292460 @default.
• W4309388545 cites W2082726173 @default.
• W4309388545 cites W2087665466 @default.
• W4309388545 cites W2087995176 @default.
• W4309388545 cites W2088253641 @default.
• W4309388545 cites W2092004666 @default.
• W4309388545 cites W2092939107 @default.
• W4309388545 cites W2095932809 @default.
• W4309388545 cites W2096854390 @default.
• W4309388545 cites W2097878023 @default.
• W4309388545 cites W2103011422 @default.
• W4309388545 cites W2103289668 @default.
• W4309388545 cites W2105054044 @default.
• W4309388545 cites W2105933619 @default.
• W4309388545 cites W2106495485 @default.
• W4309388545 cites W2113262521 @default.
• W4309388545 cites W2119498761 @default.
• W4309388545 cites W2127225632 @default.
• W4309388545 cites W2128983432 @default.
• W4309388545 cites W2129524381 @default.
• W4309388545 cites W2142820105 @default.
• W4309388545 cites W2144206769 @default.
• W4309388545 cites W2144797754 @default.
• W4309388545 cites W2145026015 @default.
• W4309388545 cites W2145352132 @default.
• W4309388545 cites W2151799721 @default.
• W4309388545 cites W2155561150 @default.
• W4309388545 cites W2159999899 @default.
• W4309388545 cites W2162337121 @default.
• W4309388545 cites W2167279371 @default.
• W4309388545 cites W2168376037 @default.
• W4309388545 cites W2191028637 @default.
• W4309388545 cites W2194404144 @default.
• W4309388545 cites W2335811386 @default.
• W4309388545 cites W2340686730 @default.
• W4309388545 cites W2343938601 @default.
• W4309388545 cites W2466315799 @default.
• W4309388545 cites W2489477621 @default.
• W4309388545 cites W2531523916 @default.
• W4309388545 cites W2571319199 @default.
• W4309388545 cites W2580091136 @default.
• W4309388545 cites W2605974076 @default.
• W4309388545 cites W2740634275 @default.
• W4309388545 cites W2761234508 @default.

• next