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• W4309399403 abstract "Abstract Background: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce. Aim: To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material. Method: A sample of 104 participants (median [IQR] 75 [72–80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p <0.05 were used. Results: Median (IQR) time to follow-up was 25 (23–26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045). Conclusion: Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH." @default.
• W4309399403 created "2022-11-26" @default.
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• W4309399403 date "2022-11-17" @default.
• W4309399403 modified "2023-10-18" @default.
• W4309399403 title "Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study" @default.
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• W4309399403 doi "https://doi.org/10.21203/rs.3.rs-2267277/v1" @default.
• W4309399403 hasPublicationYear "2022" @default.
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