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- W4309400245 abstract "Conventional neurostimulators deliver charge-balanced biphasic current pulses through metal electrodes implanted near a neural target to excite neurons and achieve a therapeutic goal. This type of stimulation avoids accumulating charge on the electrodes so that adverse electrochemical reactions are eliminated or minimized. However, these devices are mostly limited to generating phase-locked, excitatory neural activity. In contrast, direct ionic current can excite, inhibit, and control neural sensitivity. For this reason, we are developing a Freeform Stimulator (FS) neural implant. It uses a microfluidic system to convert charge-balanced current waveforms through the electrodes embedded in the device into ionic current waveforms at the output ports to provide arbitrary non-pulsatile waveforms for neuromodulation. Because there is no net charge accumulation on the metal electrodes within the device, the formation of bubbles and electrochemical byproducts is prevented. Previous publications have described the progress of the development of multiple aspects of the physical prototype. Here, we describe and model the closed-loop control system used to operate the device." @default.
- W4309400245 created "2022-11-26" @default.
- W4309400245 creator A5011392125 @default.
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- W4309400245 date "2022-10-13" @default.
- W4309400245 modified "2023-09-27" @default.
- W4309400245 title "Freeform Stimulator (FS) Implant Control System for Non-Pulsatile Arbitrary Waveform Neuromodulation" @default.
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- W4309400245 doi "https://doi.org/10.1109/biocas54905.2022.9948622" @default.
- W4309400245 hasPublicationYear "2022" @default.
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