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- W4309403786 endingPage "113985" @default.
- W4309403786 startingPage "113985" @default.
- W4309403786 abstract "Antidepressants refer to psychotropic drugs which are used to treat mental illness with prominent emotional depression symptoms. It was reported that antidepressants had associated with anti-carcinogenic function which was associated with various signaling pathways and changing of microenvironment. Its mechanism includes cell apoptosis, antiproliferative effects, mitochondria-mediated oxidative stress, DNA damaging, changing of immune response and inflammatory conditions, and acting by inhibiting multidrug resistance of cancer cells. Accumulated studies showed that antidepressants influenced the metabolic pathway of tumor cells. This review summarized recent developments with the impacts and mechanisms of 10 kinds of antidepressants in carcinostasis. Antidepressants are also used in combination therapy with typical anti-tumor drugs which shows a synergic effect in anti-tumor. By contrast, the promotion roles of antidepressants in increasing cancer recurrence risk, mortality, and morbidity are also included. Further clinical experiments and mechanism analyses needed to be achieved. A full understanding of the underlying mechanisms of antidepressants-mediated anticarcinogenic effects may provide new clues for cancer prevention and clinical treatment." @default.
- W4309403786 created "2022-11-26" @default.
- W4309403786 creator A5006078203 @default.
- W4309403786 creator A5016902887 @default.
- W4309403786 creator A5056259030 @default.
- W4309403786 creator A5058100842 @default.
- W4309403786 date "2023-01-01" @default.
- W4309403786 modified "2023-09-26" @default.
- W4309403786 title "The application of antidepressant drugs in cancer treatment" @default.
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